Good morning my name is Mike, and I will be your conference operator today. At this time I would like to welcome everyone to the Bristol-Myers 2015 Second Quarter Results Conference Call. All lines have been placed on mute to prevent any background noise. After the speakers remarks there will be a question-and-answer session. I will now turn the call over to John Elicker. You may begin your conference. John E. Elicker - Senior Vice President, Public Affairs & Investor Relations: Thanks Mike. And good morning everybody, and thank you for joining our second quarter earnings call. With me this morning are Giovanni Caforio our Chief Executive Office; Charlie Bancroft, our Chief Financial Officer; Francis Cuss, our Chief Scientific Officer; and Murdo Gordon Head of our Worldwide Markets. Giovanni and Charlie will have prepared remarks, and then Francis and Murdo will be available in addition for Q&A. I'll take care of the legal requirement before I turn it over to Giovanni. During the call we will make statements about the company's future plans and prospects that constitute forward-looking statements. Actual results may differ materially from those indicated by these forward-looking statements as a result of various other factors, including those discussed in the company's SEC filings. These forward-looking statements represent our estimates as of today and should not be relied upon as representing our estimates as of any subsequent date. We specifically disclaim any obligation to update forward-looking statements even if our estimates change. We will also discuss non-GAAP financial measures adjusted to exclude certain specified items. Reconciliations to these non-GAAP measures to the most comparable GAAP measures are available at our website. Giovanni?

Thank you, John, and good morning, everyone. It is a privilege to be here as CEO to lead today's call with you, and to tell you how excited I am about our future, about the opportunities we have before us. Building on our success over the past few years, we are beginning an exciting new chapter. One characterized by the opportunity for growth, for leading a transformation in the way cancer is treated, and for strengthening and expanding our diversified portfolio of specialty medicines. And we are starting this next chapter from a position of strength. We have an established proven strategy. We have a strong portfolio of marketed products. We have a promising pipeline, and exceptional talent. I am fully confident that we are well positioned to build on, and further strengthen, our leadership position in immuno-oncology through Opdivo. I'm also confident we can deliver on the promise of our portfolio and our pipeline, within immuno-oncology and beyond immuno-oncology. As I mentioned, we are about to begin a period of growth. Over the next five years, we expect growth to come primarily from Opdivo and Eliquis with important contribution from the rest of our existing portfolio of innovative medicines. With Opdivo we will leverage our leadership position in lung, melanoma and renal cancers. In non-small cell lung we are extremely well positioned, given the two positive Phase III studies demonstrating improved overall survival. In melanoma, Opdivo and Yervoy are currently marketed, and we believe the combination regimen will be an important treatment option for patients. In renal cancer the early stop of study 25 announced this Monday due to an advantage in overall survival confirms the promise of Opdivo in this important disease where unmet need remains high, and where we have a significant time advantage versus other competitors.…

Thank you Giovanni, and good morning everyone. As Giovanni mentioned we had a very good quarter which was driven by strong sales growth of 7%, or 16% excluding the impact of foreign exchange. Overall FX had a negative impact on EPS of approximately $0.06. Let me provide a few highlights. Eliquis sales were $437 million, up 23% sequentially from the first quarter with good growth both in the U.S. and international. We continue to see strong new to brand prescription trends with both cardiologists and primary care physicians across the broad market. Opdivo sales were $122 million for the quarter. We are seeing strong performance metrics with the approval in lung cancer with encouraging early trends in terms of access, reimbursement and abandonment of chemo in second-line squamous lung cancer in the U.S. Additionally we received EU approval in both first and second line melanoma last month, and have launched in Germany where early trends are strong. And, as noted by Giovanni, we just received approval for squamous lung cancer in the EU as well. Opdivo has now been approved in over 30 countries. Yervoy sales in the U.S. were $136 million in the second quarter, a 21% decrease from prior year. Outside the U.S., sales totaled $160 million, which is a 28% increase excluding FX. As expected we are seeing an impact on Yervoy from the PD-1 class in the U.S. This will likely continue in the short term until the Opdivo plus Yervoy combination regimen is approved later this year. Longer term, we believe Yervoy could have an important role to play in combination with Opdivo in multiple tumors. Hep C sales were very strong for the quarter at $479 million. Included in sales for the quarter is a one-time positive impact of $170 million related to an…

The first question is from Steve Scala with Cowen. Steve M. Scala - Cowen & Co. LLC: Thank you. I have a couple questions. First in Bristol's all-comer trials versus its PD-L1 selected trials, is there a meaningful difference in the rate of patient enrollment? And if yes, is that due to challenge of finding patients who have that level of selectivity, or is it due to physician reluctance to do the screening for expression in the first place? And secondly, Roche implied this morning that the chemo-combo data they will show at ESMO will continue to show strong results. Has Bristol considered taking another look at chemo-combos based on Roche's continued success with those combinations? Thank you. Francis M. Cuss - Chief Scientific Officer & Executive VP: Well, good morning Steve. It's Francis Cuss here. So thank you very much for that question. We have not seen any difficulty in recruiting patients for any of our studies with Opdivo or indeed the combination. And certainly it's not related to the ability to look for PD-L1 expression or not. I would say as, a physician obviously the less one has to do to be able to treat the patient and really have a good idea of the benefit, that makes a lot of sense. So we are very happy that we're heading towards broad labels for the tumors we're looking at, and we've fully characterize the PD-L1 expression. Moving to the combinations with chemotherapy, we believe we have very comprehensive data set now with various chemotherapy Nivo combinations – probably with the longest follow-up in the industry. Based on our comprehensive data from CheckMate-012, combinations of Opdivo with conventional chemo regimens may sometimes achieve high and durable responses. But we've seen with longer follow-up that the survival at a year was actually no different for Opdivo combinations with chemo compared to Opdivo monotherapy. In effect what we saw was additive but non-durable response rates at the cost of additional toxicity. Now just to put this in context we showed at ASCO last time, one year survival for Opdivo mono-therapy of about 70% to 85% regardless of PD-L1 expression. So we are focused on the Opdivo Yervoy combo and we'll in addition continue to explore other scientifically driven combinations to advance our first line strategy and our position. We are additionally interested in nontraditional chemo-combo regimens including innovative approaches to sequences and maintenance. So let me just remind you, our strategy for first line is to improve survival and replace (20:31). And to do this we are exploring multiple Opdivo combinations as well as mono-therapy. And earlier I-O assets targeted therapies and chemo, both internally and externally. Thank you.

Steve, let me just add to what Francis just said. This is Giovanni. With respect to your first question, we're actually very excited that we are enrolling ahead of schedule, as Francis said. And that's clearly an indicator of the interest in the first line trial with Opdivo. And with respect to your chemotherapy question, just to add again to what Francis said. What's really interesting that we are seeing in the marketplace, in the very early days of our launch in second line, is the speed at which chemotherapy is being abandoned. There's clearly concerns with the limitations in terms of long-term efficacy, and obviously the side effects are something that physicians and patients are actually being really excited about abandoning as well. So I think that's an important first early learning from the marketplace. John E. Elicker - Senior Vice President, Public Affairs & Investor Relations: Thank you Steve. Mike, can we go to next question please?

Next question is from Andrew Baum with Citi.

Hi, I have three questions, if I may. Firstly I'm just interested in your reaction to the negative news in relation to the Yervoy trial in small cell lung cancer. My understanding is the tumors have very high mutational loads. Plus smokers, they may have had prior radio therapy. I mean, all of the factors that you may increase the providency of response. So any additional insights you have on that, and what it means will be interesting. Second, I saw some commentary that potentially the ARISTOTLE data may allow for approval in some sub-types of viselar (22:26) AF which is not possible for your competitors in that space. To what extent do you intend to prosecute this? And could it be used as an additional competitive tool in that market? And then finally, your guidance, although raised continues to look at more than achievable. Are there any additional headwinds that perhaps we ought to be considering that we're not taking into account? Many thanks. Francis M. Cuss - Chief Scientific Officer & Executive VP: Good morning Andrew. Obviously I'm disappointed that the studies in small cell and prostate didn't meet their primary endpoints with Yervoy. And I think it's really important to say, we never expected that every I-O agent in every tumor was going be successful. But again we're here to follow the science and generate the data. Now I think it's also fair to say that based on the pre-clinical science and the promising clinical data we've seen, our strategy is rapidly evolving to studying combinations of Yervoy and Opdivo in multiple tumors. So, just to talk about small cell for a moment, we presented data at ASCO – that's the CheckMate-032 study that showed activity in platinum sensitive and resistant patients in both mono-therapy, but even more interestingly in combination. And with very good tolerability. And I think it's also important to say we've shown activity in prostate cancer with Yervoy even though we didn't actually meet our primary end points. So let me say that I think we believe in the importance of the complementary mechanism of action in I-O. We are firmly committed to Yervoy, which I think is a very important part of our combination strategy, combined with Opdivo in multiple tumors. And I think it's important to say that we're making very good progress at the moment in melanoma with validation of our EU combo filing just this week. And we have the upcoming PDUFA date at the end of September for the U.S. 069 filing. Turning to the ARISTOTLE data. I'm not going to get into the details of our regulatory strategy around this but we are looking at every opportunity to use what we believe is a very important data set. Talking to KOLs and the regulatory authorities in terms of providing additional information for this very important area.

Andrew, this is Charlie. I'll briefly touch on your guidance question. We raised guidance because we feel very strongly and encouraged about our sales trends about the key products that are – not just for us now, but as we look into the future. We did have some one-off items where the French ATU, which helped us in the first half. And remember that we had Abilify in the first – basically in the first quarter that doesn't replicate. I would also mention that gross margin, the first half of the year we were averaged at 78%. I've guided to 76%. We're starting to see the unwind of the favorable foreign exchange we see in the first half. And also remember that the expenses that both Giovanni and I spoke about earlier by and large accrue to us in the second half of this year.

And just to add on that, Andrew, I would say, as I mentioned at the beginning, we really are entering in a period of exciting growth. I am very encouraged by the fact that we have very strong clinical momentum, good progress on the regulatory front. Commercial execution is strong. And you'll see the trends for our growth products continue. Obviously Charlie described some of the dynamics in the second quarter. But we've made a decision to make a number of strategic investments at a time in which we really are in a position of strength, beginning an important phase of growth. And I think I'm really confident in how this chapter that I describe between now and 2020 will play out for us. John E. Elicker - Senior Vice President, Public Affairs & Investor Relations: Thanks, Andrew, for your questions. Mike can we go to the next question please?

Next question is from Vamil Divan with Credit Suisse. Vamil K. Divan - Credit Suisse Securities (USA) LLC (Broker): Yeah. Thanks so much for taking the question. Two if I could. So one is you mentioned the diversification that you want to do both within I-O but also outside of I-O. And I guess my question is given how large most of us feel the I-O opportunity's going be for you, to remain well diversified outside of I-O, I'm curious if you feel you need to do some sort of larger acquisition in order to gain a presence in some of the areas that you talked about that matches up to sort of what you're going to be getting in the I-O side of things/ And then second, just you touched on this a little bit earlier, but in terms of the combination approaches in the front line setting for lung cancer. Obviously a lot of focus has been on Opdivo and Yervoy. Can you just at a high level, Francis, maybe just give us a sense of some of the other combinations that you're working on? Which ones are you most excited about? I know you have a number that are in progress. But based on your early data, kind of which ones would you say that you'd get as the most optimism for potentially giving us positive data in future? Thanks.

Yes, Vamil. Thank you. This is Giovanni. Let me just answer the first question on diversification. And then Francis will make some comments on combination strategies. So my perspective is that obviously at the center of our strategy is immuno-oncology. And as I said at the beginning, when we think about the next period of growth between now and 2020, the next five years, our growth will come disproportionately from Opdivo and Eliquis. And within Opdivo, obviously there is an element of diversification as well because our staffing strategies are really focused on lung, and melanoma and renal cell. But then we are expanding into a large number of other tumor opportunities. Longer term, we believe we have an exciting early pipeline within immuno-oncology, and in a select number of areas in which we are focused that can drive our growth in the medium and the long-term. And the areas are the ones we've discussed before. So CV with a focus on heart failure, immunology, and the areas of fibrosis and genetically defined diseases. In all of those areas, we have ongoing programs which are early, but are potentially transformative. And with respect to how we complement that, our business development strategy is – does not change, and it's really the strategy that we've articulated before. I think that one of our core strength as a company is really our ability to complement internal R&D with business development. We've clearly demonstrated that in fibrosis with the recent agreements we had. And even in CV through our deal with uniQure. So you will see us continue to execute our strategy in business development to complement our internal programs there. Francis M. Cuss - Chief Scientific Officer & Executive VP: Good morning. So let me just draw you back a little bit…

Next question is from Jami Rubin from Goldman Sachs. Jami Rubin - Goldman Sachs & Co.: Thank you. Charlie, this is for you. First are you signaling higher levels of investment spending now because you think that the opportunity set for I-O is even bigger than you had originally imagined? Or is it because the market has become more competitive? And secondly, can you commit to investors that we will see significant bottom line leverage? Because it sounds like you're pushing that out a bit. Is that the right way to look into this? Is that going to be next year? Is it going be in 2017? And again does the renewed higher level of spend delay the margin leverage or does it actually accelerate the margin leverage? Or strengthen it rather. Thanks very much.

Thank you, Jami. I think the I-O opportunity as we see it, with the continued good clinical outcomes, stoppage of trials. I think we mostly see it as our opportunity to just continue to reinforce our leadership position in I-O. Clearly we recognize that I-O is immensely competitive and that has a small factor, but I think it's largely due to how we see our competitive position within the overall I-O space. As it relates to the bottom line and how we potentially see leverage. To seize on that opportunity as we continue to see the evolution of that, and not only that, but our performance in the market, we see that it's required to continue to invest to maximize that opportunity. And I don't necessarily see that the leverage – I can't comment on 2016, but as I look further out to the back end of this decade, I will see that that will ultimately improve our leverage.

Let me just, Jami, just further reinforce the point that Charlie has made. When you look at our immuno-oncology opportunity there is very strong momentum from a clinical perspective. I think it's fair to say our strategies have been validated clearly this year. There is extremely good execution from a regulatory perspective, not only in the U.S. but in Europe and internationally as well. Commercial execution is strong. The early indicators are encouraging. And I think that our decision to incrementally invest is really one that starts from our position of strength, and the confidence we have in the magnitude of the opportunity in the medium and in the long term. And as I said at the beginning, for us this is an unprecedented set of opportunities, and we're making the right investments behind them. Obviously we are very conscious of the comment you made with respect to leverage and increased profitability. And I think as we look at this period we see that happening, as Charlie said. John E. Elicker - Senior Vice President, Public Affairs & Investor Relations: Thanks, Jami. Mike, can we go to the next question please?

Next question is from Tim Anderson with Bernstein. Timothy M. Anderson - Sanford C. Bernstein & Co. LLC: Thank you. A few questions on immuno-oncology. Can you talk about how you think the PD-L1 bio marker will play out in Europe, in the near or intermediate term? There's been several companies that have commented that they think European payers and maybe even regulators will be more aggressive in pushing the bio marker as a kind of a treatment decision tool in lung cancer. Second question is in first line lung in PD-L1 negative patients. Do you see any opportunity for PD mono-therapy? Or at this point is it really only looking like combination is going to be the path forward again in bio marker negative patients? The reason I ask is obviously there's some divergence in how it seems to be working in second line, versus how it may work in first line. And then Opdivo pricing in Germany. Can you just mention where you are relative to the U.S.?

Yes. Tim, let me just start on the first part of the question. Murdo will further expand on Europe, including the pricing in Germany, and then Francis can answer your comments on first line. I think we're in a very, very strong position globally in having a data set across all patient populations that enable us to describe to physicians and patients and payers, the role of bio markers. And I think it is important that our strategy there has been validated. The roll of biomarkers is different, it depends on the line of therapy, it depends on the tumor. But we have the right data sets to have those discussions. We are receiving strong feedback from physicians including in Europe regarding our strategy. And I'll ask Murdo to give you some more insights there. Murdo Gordon - Senior Vice President & Head-Worldwide Markets: Yes, thanks, Giovanni. Thanks, Tim, for the question. We are as Giovanni highlighted hearing from European thought leaders that consistent with some of the perspective of U.S. thought leaders post ASCO, that the role of PD-L1 is unclear in selecting patients. So that consistent perspective has been played back. That being said, given the nature of the healthcare systems across Europe, we could end up in discussions with payers in Europe where they are seeking to restrict Opdivo in second line patients in lung cancer. So we will work obviously very closely with each of the payers in Europe to help them understand the full breadth of the data as Giovanni has highlighted. We are in a position to describe the efficacy of Opdivo across a broad range of second line patients, across a broad range of histologies. In Germany we've been fortunate, we've had a very quick start. As you know, reimbursement is not a…

And Tim, we feel very strongly about our first line lung strategy. As we said at the beginning in answering the first question, the enrollment of the monotherapy trial in PD-L1 positive ahead of schedule. As you know we've posted the combo trial on ClinicalTrials.gov, and that study on the combination is one that is clearly very, very important for us. As you know, we've done a lot of early work in that space in understanding the regimen, the combination regimen that can be most effective in patients in lung cancer. And I think you'll see some of that data when we go to the lung, the World Lung meeting in September from further analysis of Study 12. John E. Elicker - Senior Vice President, Public Affairs & Investor Relations: Thanks Tim for the questions. Mike, can we go to the next one please?

Next question is from John Boris with SunTrust.

Thanks for taking the questions. First one just Opdivo related on renal cancer. Just any – I know it's probably early since you just top-lined, but any thoughts around the publication and presentation strategy along with your regulatory strategy for renal? In addition, would seem like – can we get an update on your hematology glioblastoma multiforme head and neck trials. It seems as though those trials seem to be enrolling with potentially data sometime in 2016. So any update there? On HCV on the $170 million, can you provide any update on what the price was per patient that you secured in the French market? And then lastly on Eliquis, just any quantitative metrics that you have on the new to brand share in cardiology and primary care would be helpful? Thanks.

Sure. So why don't Francis start with your questions on renal and hematology and then we'll take the Hep C questions. Francis M. Cuss - Chief Scientific Officer & Executive VP: Good morning, John. We were obviously very excited when the study was stopped early based on the top line data from the interim analysis. And the fact that Opdivo demonstrated an improvement in overall survival versus the standard of care (41:26) we believe from previous studies is just about unique. Can't talk more about the data before it's presented, but I will say we're working with the investigators on a future presentation and a publications results as soon as possible. As far as the – our regulatory strategy I'm not going to go into detail, but I think as you've seen we've shown recently in melanoma in lung we can work together and very quickly with the FDA and other health authorities. And we'll be looking to submit that data as soon as possible. Let me just talk about the other data that might be coming out. I think in addition to the nine registration studies in the last year that we've had positive data, we have a further 25 either ongoing or planned. You mentioned some of them. As we look forward, obviously it depends on the data, although I will say recruitment is going well, but we may see information next year in 2016 in Hodgkins, non-Hodgkins lymphoma and bladder potentially. And potentially some others. So it's going be – we're going to continue seeing differentiated data, which is what we're trying to do. But I think in the near term, with all the differentiated data we've had, we're certainly focusing on getting those submissions in and getting the broadest label we can as quickly as possible. Murdo Gordon - Senior Vice President & Head-Worldwide Markets: And, John, the other question you asked regarding the ATU in France it's a program that was open from beginning of March until the end of October. We accrued roughly 4,000 patients in that program. And the price for a 12 week supply was €25,500, and that's public. John E. Elicker - Senior Vice President, Public Affairs & Investor Relations: Great. Thanks John, for the questions. Can we go to the next one, Mike, please?

Next question is from Mark Schoenebaum with Evercore ISI.

Oh, hey guys, just a couple questions. One, on World Lung we're obviously going to see the updated data from the Nivo/IPI Phase II that presumably informed the dose selection for Phase III. And I was wondering, I realize you can't give us any data, but I was just wondering if we would see one year overall survival data from the Phase III regimens. And if so, should we hold those data to the benchmark that you provided for Nivo monotherapy which you stated was 70% to 85% overall survival in the first line setting? And second of all, this has sort of been asked by other analysts, so I don't mean to be redundant, but there's been so much deal activity out there this year, especially gobbling up some of these biotechs. And you guys have chosen generally speaking to do smaller stuff. I'm just wondering is that because – is that your strategy to kind of do generally speaking smaller stuff, or do you feel that there's a valuation disconnect in this mid-cap biotech universe? I ask this because an hour ago John Lechleiter over at Lilly actually stated on his earnings call that he thinks mid-cap biotech is in a bubble. Thank you. Francis M. Cuss - Chief Scientific Officer & Executive VP: Good morning, Mark. First of all, as you say, you'll be glad to hear – finally you will be hearing about the 012 data on the combination. These are the combinations, the regimens that we have taken forward into our trial, the 227 trial. I will say we're excited about it. We've consulted obviously with thought leaders and they also recommend that we should go forward with these. I'm not going to talk specifically about the regimens, but what I will say is these are pretty large studies, of large numbers of patients for an early study, approximately 50 per group. We have data on all patients up to about six months, but obviously as you appreciate as these mature, some of them are further out and they will continue to inform going forward. But I'm afraid you'll have to wait for specifics until it's presented.

Mark, on business development. Let me just reiterate what I said before, our strategy does not change. We are indifferent with the size of the opportunities, but I will ask Charlie to comment further.

I would just say that, John, we have a lot of balance sheet flexibility to do deals of various sizes. I think our sweet spot if you look back historically has been in the smaller type deal. I wouldn't necessarily say that that's all we look at. We look at a number of things. As it relates to mid-cap biotech prices, if you look at how they've performed over the last several years comparative to larger cap pharma or to the S&P, significantly outpaced. So there is a significant valuation. I'd hate to call it a bubble, because who knows how long this may last. But it is, I would say, well out-performed the market. John E. Elicker - Senior Vice President, Public Affairs & Investor Relations: Thanks, Mark, for questions. Can we go to next one, please, Mike?

Next question is from Seamus Fernandez with Leerink.

Thanks. I have a couple of questions. So first, as we think about the CheckMate – 012 data, Francis can you just give us just generally what features really drove the recommendation internally and by your thought leaders to really utilize this data set, the 012 data set? Because I think we're all wondering how should we think about this and how did it inform 227? In terms of response rate, survival duration, depth of response, what were the features that you think were differentiated? Separately, your comments on the data sets in combination with chemotherapy are helpful, but when might we actually see that data really showing the diminution of the durable responses over time? And then the last question just in terms of how uptake is actually occurring in the market today, what data, if you do have it available, can you share with us with regard to the mix? So what percentage of Opdivo patients are melanoma patients? What percent are squamous lung, and what percent are non-squamous? And then if I could just one final question. There was a second kidney cancer study that announced data and provided the data in their press release with regard to overall survival. How do you see Opdivo competing with that asset, Cabozantinib, in the public market? Thanks.

Seamus, why don't we start with the – your questions on 012 and lung broadly for Francis, then we'll go to Opdivo uptake and, Murdo will give you some insights there. Francis M. Cuss - Chief Scientific Officer & Executive VP: Okay. So good morning, Seamus. So when we look at the data set we have, where obviously the focus is really on maintaining the kind of efficacy we've seen in the combination, but wanting to get as close in terms of tolerability to Nivo monotherapy. And so the first thing to look at in these two will be the tolerability. As far as the efficacy's concerned, as you know, we've focused pretty much on the durability of responses, or overall survival, or one year landmark survival. And as I said we had six months survival for all patients in this study and it's maturing. So it's really about this therapeutic index both tolerability and efficacy. In terms of the chemo data I believe we have presented some of that. Obviously as is important with these exploratory studies the data matures and continues to become more informative with time. Can't tell you exactly when we will be presenting it but we will be sometime in the future. And just an R&D comment on the Cabo data. Obviously we haven't seen the full data set but I think if you look at our Phase II monotherapy data for Opdivo in renal cell, I think we showed superior efficacy to TKI's [tyrosine kinase inhibitors] with also TKI – sorry, with superiority in terms of tolerability also.

Murdo? Murdo Gordon - Senior Vice President & Head-Worldwide Markets: And, Seamus, your question regarding uptake, we're really excited about what we're seeing in the market with Opdivo. The initial launch in melanoma was a strong launch. Obviously in second line what we are seeing now is that we are about at parity with Keytruda in the community setting, and we're gaining good market share in the institutional setting. I will say in melanoma we're also seeing some off label usage since ASCO of PD-1 inhibitors in front line, as you recall from Charlie and Giovanni's remarks that's put some pressure on Yervoy, but Opdivo is seeing lift in a non-promoted setting there. And in lung we've really had a very rapid penetration of the squamous second line market. We're getting about two-thirds of new patients there, and that happened very rapidly. And then since NCCN updated June 12 post-ASCO we've also seen a very nice uptick in lung overall. Clearly that's another off label indication given that we're only promoting in squamous right now. So I would say very soon we'll see lung eclipsing our melanoma business and we'll see some nice growth out of Opdivo this year.

Yea. So it's early days but the trends we are seeing are really encouraging. I should say that our launch in Germany as we mentioned before is off to a really strong start as well. It's even earlier there but execution so far has been very strong. John E. Elicker - Senior Vice President, Public Affairs & Investor Relations: Thanks, Seamus, for the questions. Can we go to the next one please, Mike?

Next question is from Chris Schott with JPMorgan.

Great. Thanks very much. Just a couple additional follow-up commercial questions on Opdivo. Can you just elaborate a little bit more in terms of the lung adoption so far? Just where are you seeing that in terms of community versus some of the major kind of medical centers? Are you seeing good community uptake already in lung? Or is that still to come? Second, on the European side of things, just can you elaborate how you're thinking about the ramp ultimately in Europe? Any other hurdles we should think about? Just how should we just think about the broader dynamics beyond Germany over time? And then the final question was just on the non-traditional chemo dosing with Opdivo in lung. Just any more color of specifically what you're looking at there and when we could see any initial data? Thanks so much. Murdo Gordon - Senior Vice President & Head-Worldwide Markets: So, Chris, let me take the first couple of questions and then I'll pass it over to Francis for your last one. In the U.S. we are seeing very balanced uptake. So we're seeing very rapid adoption in second line squamous in the community and in the academic setting. As you may recall, we did a large amount of education around immuno-oncology when we launched Yervoy and I think having a broad understanding of how the immune check point inhibitors work, the safety profile being particularly good with Nivolumab has helped us have a very rapid penetration in the community. And so I think we'll expect that to continue with broadening indications. In Europe, we're very encouraged by what we've seen as Giovanni mentioned in Germany. I would say that the enthusiasm and interest in second line squamous and in first and second line melanoma is very high. I think obviously as you know the rate limiter in many European markets will be how quickly we can secure market access, and we have a lot of people on the ground working very closely with the payers and reimbursement authorities across Europe to expedite that as best as possible while still securing a good reimbursement price.

So I would say you'll probably see obviously, as always in Europe, a very similar sequence as we saw for Yervoy and we see for other new products with rapid launch and uptake in countries where that process is short. But continuing significant number of launches over the next 12 months to 18 months across all European markets. Francis M. Cuss - Chief Scientific Officer & Executive VP: Good morning, Chris. So the thinking really behind the sequencing is, there's sort of two potential hypotheses. One is that you might generate more antigens from cytotoxicity of the tumor, and that might be a good thing, and you might want to get that in before the I-O. The opposite one is that you might actually be causing some immune suppression with chemotherapy, and actually reducing the benefits of I-O. And, of course, what we have seen is probably better one-year survival in our exploratory studies in first line with Opdivo than with second line. Might be other features involved with that, too. So we think it's very important to understand, as we are with I-O agents, the sequence and actually explore exactly what the right approach to this might be. Those studies are ongoing. We don't have any plans at the moment – we have no data, but no plans to present yet. But obviously sometime in the future we will be doing that. Thank you. John E. Elicker - Senior Vice President, Public Affairs & Investor Relations: Great. Thanks, Chris, for the questions. Mike, I think we have time for one more. We're at the bottom of the hour here.

The last question is from Gregg Gilbert with Deutsche Bank.

Thanks. Just a couple quick ones. First, Giovanni, just so I'm clear on your theme of diversification which has been quite clear since you took over. It sounds like you think the portfolio will naturally diversify as it is now, combined with your pipeline and licensing efforts. Am I missing something? Are you suggesting that Bristol needs to do more of something to diversify faster than it already is? I just want to be clear on that. And my second question on Opdivo. I'm curious if any payers have tried to get you into a contracting environment yet with two similar therapies out there now, albeit with different data sets, and others to come. Thanks.

Okay, let me comment quickly on the diversification issue. I think that when we look at our business, the period between now and 2020, the next five years, the growth as I said is clearly – will clearly come disproportionately from the growth of Opdivo and the potential of Eliquis. Within Opdivo there is a degree of diversification. Long term as we think about a second cycle, we are thinking about our early pipeline generating opportunities that are more diversified for us within immune-oncology, because as Francis mentioned, we have clearly assets in the clinics; we're bringing six more assets into the clinic. So there is an element of diversification which is already within immuno-oncology, but then we have exciting early programs in the other areas. So it is a concept that does not require us to change our approach, and in fact what I mentioned at the beginning, importantly, is that our business development strategy remains pretty much the same. Let me ask Murdo to make – to give you some perspective on payers. Murdo Gordon - Senior Vice President & Head-Worldwide Markets: Thanks, Giovanni. Thanks, Gregg. We've really been fortunate with the quality of data that have been generated behind Opdivo. The value that we've been able to establish for patients with metastatic melanoma and non-small cell lung cancer, and I think that's been recognized by payers. We've established very broad and very rapid access in the U.S. The breadth of indications that we hope will follow will also further strengthen our ability to weather any attempt that any payers may have to try to restrict these agents, which is very difficult to do in the oncology area with drugs like Opdivo with overall survival benefits. So we feel very good about our current access and our ability to sustain that going forward.

So thanks, everyone. Let me just close the call and say again, we had a very strong quarter. We have good momentum with our long-term growth drivers, significant clinical progress, strong regulatory developments, very good commercial execution and trends in the marketplace. We are making the right investments. It is clear to me that we are well on our way and entering an exciting period of growth for the company. So thanks everyone. And have a good day. John E. Elicker - Senior Vice President, Public Affairs & Investor Relations: Okay. Thanks, everybody. Mike, that's going to conclude the call. As always, if you have follow-ups you can reach me or Randy or Bill later today or tomorrow. Thanks.

This concludes today's conference call. You may now disconnect.