Good day and welcome to the Bristol-Myers Squibb 2018 Fourth Quarter Results Conference Call. Today’s conference is being recorded. At this time I would like to turn the conference over to Mr. John Elicker, Senior Vice President, Public Affairs and Investor Relations. Please go ahead, sir.

Thank you Greg [ph], and good morning, everyone. And thanks for joining the call today. We do have a lot to discuss including the quarter, our full year results, 2019 outlook as well as some additional perspectives on our announced acquisition of Celgene. We will be using a slide deck today, so we did email it to you about 15 minutes ago. The slides are also available on our website. Joining me today with prepared remarks are Giovanni Caforio, our Chairman and CEO, Charlie Bankcroft, our CFO and Chris Boerner, our Chief Commercial Officer, Tom Lynch is our Chief Scientific Officer and will also be here for Q&A. You’ll see on slides two and three of today’s presentation our legal disclosures. And with that on slide four, I will turn it over to Giovanni.

Thank you John and good morning everyone. I am proud to speak to you today about excellent results in 2018 and the exciting outlook for the company in 2019 and beyond. As John said, let’s start on slide four. Today, we will cover our 2018 financial results, the planned Celgene acquisition and how we are thinking about this in terms of the financials of the acquisition and the value we are creating for shareholders. Before we start, I’d like to address today’s announcement on our FDA application for Checkmate-227 in high TMB non-small cell lung cancer patients. As you saw in our press release, we have decided to voluntarily withdraw the application. This is because following recent discussions with the FDA, we believe it is important to further characterise the interaction between the two biomarkers of TMB and PD-L1 in these patients in order to understand their relevance to overall survival in this setting. To do this, we will need data from Part 1A of CheckMate-227 that will not be available during the review period for this application. I would like to emphasize that we continue to believe that TMB is scientifically important and we look forward to continuing to advance our research in this area. Turning now to slide five and our 2018 results. I could not be prouder of our very strong performance for the quarter, which wraps up a very good year for the company. This was driven by excellent commercial execution on our priority brands and disciplined expense management that has driven improvement in our operating margin. Commercial execution was strong across the portfolio with significant growth driven by our two key franchises, Opdivo and Eliquis. Our I-O franchise performed well throughout the year in highly competitive markets, and we have consistently demonstrated very strong launch…

Thank you Giovanni and good morning everyone. Let’s turn to Slide 10. We believe this transaction will bring significant financial benefits to shareholders of both companies with three defined sources of value. First is the value from the in-line portfolio of marketed products. This includes Revlimid which I know many of you have questions that I’ll try to address in upcoming slides. The second source of value are the cost synergies of approximately two and a half billion that can only be achieved by combining the operations of the two great companies. These two sources in total are substantial when you consider the transaction in aggregate. Lastly, we see significant opportunity in the Celgene pipeline, which includes five phase III assets, which are positioned to launch in the next 12 to 24 months, and a significant number of assets that are in phase I and II that will bolster our existing pipeline in oncology and INI as well as complementary platforms such as cell therapy and protein homeostasis. Turning to Slide 11, when you look at the combined company on a pro forma basis, we see a stronger, more diversified set of opportunities that will enable us to drive growth, both on the top, and bottom line through 2025. We see complementarity in the combined portfolio with near-term growth, driven mainly by the Celgene assets and subsequent growth driven mainly by BMS assets, particularly from I-O. This speaks to the strength of our in-line businesses, the short term growth potential from launches of new medicines, together with lifecycle opportunities from our I-O portfolio and a stronger late stage pipeline. The combination results in a much more balanced company, better positioned for the latter end of the next decade. As we move to slide 12, the combined company will generate substantial…

Thanks, Charlie. Turning to Slide 16. You’ve seen this slide before. It shows how the combination of BMS and Celgene will create an exciting industry leading, late stage pipeline, including six near-term launch opportunities with more than $15 billion in non-risk adjusted revenue potential. Three of these products are substantially de-risked, because the pivotal data are known or regulatory filings are well advanced, and the majority of these products are either first or best-in-class providing a meaningful opportunity to help patients across a number of disease areas. To put this potential set of launches into context, I want to provide you with some background as to why we are excited by them and why they give us the basis for sustained leadership in key therapeutic areas moving forward. In INI we will be moving from being two companies each with a single product to one INI franchise delivering Orencia and Otezla right away with the potential of adding ozanimod and TYK2 in the near future. And in haematology, we see for assets that form the first step to building on the current capabilities that Celgene brings with this Revlimid business today to establishing sustained leadership in this space. We view these near-term launches as exciting opportunities and key drivers of value in the combined company. And I’d like to take a few minutes to walk through these six up upcoming launches in more detail. Let me start with Luspatercept on slide 17. A very exciting compound from our perspective which is a potential first-in-class Erythroid Maturation Agent to address chronic anemias. As you may know, chronic anemias present a serious, unmet medical need across various indications and Luspatercept is a compelling new mechanism for treating these patients. The data presented at ASH have demonstrated that Luspatercept provides very good efficacy…

Thank you, Chris. Now turning to Slide 24, as I looked at what we are creating for the short and long term for 2025 and beyond, I feel really good. We’ve discussed in detail why the transaction makes financial sense. We talked about six near-term launches and as you know we’re also strengthening our early stage pipeline and platforms. This is a transaction that allows us to stay ahead of the curve and provide value for the long term. When I look ahead to the future, I feel very good about the position of the company. We will have a younger portfolio of market and medicines providing a more balanced payor mix, supporting a stronger reimbursement position for our medicines. These in an access and reimbursement environment that we believe will continue to evolve over the coming years. Our early pipeline will have mature giving us a diversified portfolio of late stage assets providing the next set of registrational opportunities. We’ll have a strong balance sheet with continued flexibility to invest in innovation. We would be in a strong position with a broad portfolio and deep pipeline and significant financial flexibility. I’m confidence in the company we are building and the opportunities ahead. Now, I'll turn it back to John to start the Q&A.

Thanks, Giovanni. Grey, I think we’re ready to go to the Q&A session with Giovanni, Charlie and Chris as well as Tom here for Q&A as well. So, Grey.

Thank you. [Operator Instructions] We’ll now take our first question from Alex Arfaei of BMO Capital Markets. Please go ahead. Your line is open.

Great. Thank you very much and thank you for the additional color. First question for Giovanni or Charlie, as you mentioned the combined company with Celgene should generate significant cash flow. I appreciate the general comments you made about the dividend increase. But as you look at some of your payers and your current payout ratio would you be able to I guess provide additional color. Would the payout ratio that you would expect for the combined company given the earnings accretion be similar to what you have right now? And as a follow-up could you comment on your Opdivo lifecycle planning, specifically what’s the development or what is latest on the development of subcutaneous Opdivo with your collaboration with Halozyme? And could that be used to extend the Opdivo patent life beyond 2028? Thank you very much.

Yes. Thanks. This is Charlie. In regard to your first part of your question, as I mentioned in my comments we have model dividend increases throughout the planning period always subject to Board approval of course. I don't want to comment on the payout ratio at this particular time because as you know we don't do it based on any one particular year. We look at it over the longer term, but needless to say, we did model increases.

Thank you, Alex. Regarding the product formulation, from an R&D standpoint we think it's very important to be able to create products that can be used in a variety of settings. And our relationship with Halozyme as you point out we think offers a very important opportunity for Opdivo, Opdivo, Yervoy and up to six to eight additional IO targets to be looked at in formulations that could be given subcutaneously. We think in many markets around the world and many places in the United States the ability to give a subcutaneous treatment with an IO agent or IO combination even offers a very distinct advantage. So we think that there's a lot of promise there. The implications of that on the IP, I think we have to defer that, to see how that topic evolves with time.

Grey, can we go to the next question please.

We’ll now take our next question from Seamus Fernandez of Guggenheim.

Great. Thank so much for the questions, so just two quick ones. The first one in the past Tom, you’ve given us information with regard to whether or not interim looks have been passed in particular trials. I think we have passed that in Part 1a. So Part 2 for OpdivoPlus Chemo we know is on-going is expected to finish midyear this year. Can you just tell us whether or not the interim look has been passed or not at this point? And then the second question, can you guys give us a little bit of a better sense as we think about products like bb21 and liso-cell, one of the key feedback areas that we get is the challenges that hospitals are facing when delivering in CAR-T therapy and the issue around hospitalization and the costs associated with it. So, it's not profitable today for hospitals to be able to do this. In fact they’re losing quite a bit of money. Just wondering how you guys see that dynamic evolving as you seek to launch both of these products in the next couple of years assuming the Celgene acquisition closes? Thanks so much.

Seamus, thank you. This is Giovanni. I’ll start and then I’ll ask Chris to comment on the CAR-T question you had. There is no news with respect to the rest of our first line lung cancer program. We’re not commenting on interim analysis.

Yes. So, thanks for the question, Seamus. Let me talk a little bit about how we see CAR-T evolving and the important role that the two agents we talked about will play in terms of potentially expanding the opportunity for CAR-Ts generally. You’re absolutely correct that existing CAR-T therapies have struggled a bit both with respect to logistics in the hospital as well as with respect to access in large part because of the profile of these drugs. As you know existing CAR-Ts are administered in the hospital setting. Today patients must remain in the hospital often in the ICU for treatment as well as monitoring. And one of the things that we find really exciting about particularly an asset like liso-cell is that with no significant Grade 3, 4 toxicities with the CRS rate that significantly lower than both KYMRIAH and YESCARTA around 1%, patients could potentially be monitored in the outpatient setting, and that actually bridges to your question about access. Because these patients have had to be managed in the inpatient setting the cost associated with CAR-T therapy has been very substantial above and beyond the list price of the drugs. You’ve seen some improvements in access and reimbursement for these agents over time. About two-thirds of commercial patients payers are now have put in place policies that cover these therapies. That said, anything you could do to potentially move these agents into an outpatient setting would do a number of things. Would bring the overall cost of these therapies down, it would increase the value of these assets. And importantly as I mentioned in the prepared remarks it would be an opportunity to expand the physician base who are using these agents outside of a large academic centers to potentially community centers and then ultimately expand the patient pool considered eligible for these therapies, and that's a potentially important opportunity that we see with the differentiated profile particularly of liso-cell.

Thanks Seamus for the questions. Grey, can we go to the next one please.

Thank you. We can now take our next question from Tim Anderson of Wolfe Research.

Thank you. Couple of questions. I realize this will be a difficult question to answer, but many have wondered if Bristol's buying Celgene is an attempt by you to prevent another company from potentially acquiring Bristol. So my simple question here is whether this played any role whatsoever in your decision to acquire Celgene? Second question, you sit in front of three sets of results in non-small cell lung with Opdivo, Part 1 or Part 2 and 9LA. Can you tell us which one of those you have the greatest confidence in and which ones you have the least confidence in? My guess is you would probably rank order those. Part 2 is being most likely to hit, 9LA would probably be beneath that and Part 1 is probably at the bottom. If you only hit Part 2, would you be willing to say that Opdivo will grow in 2020?

Tim, thank you. Let me just try to address both questions. To your first question, I hope that through many of the discussions we’ve had since the announcement and clearly today we been able to communicate a strong strategic rationale of the combination and the value it generates for shareholders and patients. So I -- my answer is we are creating a great company with complementary franchises of marketed products, an opportunity to launch six new products in the next 24 months and doubling the size of our early pipeline in therapeutic areas we know well. We’re really excited about the strategic and financial value of the transaction. With respect to your second question, my perspective is that as we’ve said many times we have multiple opportunities to play a role in lung cancer. I think we need to see the data readout to understand the data. And as you mentioned Study 1a, Part 2 and 9LA are all important components of our lung cancer program. We’ve communicated before our expectations with respect to the timing of those programs and there is really no change there. But more importantly as Charlie mentioned when we think about the Opdivo business this is a growing franchise. And you've seen on one of the slides we presented today, the breadth of opportunities that we have over the next few years with over 20 registrational trials ongoing. There are clearly a number of opportunities in lung cancer this year. We have an exciting and very broad adjuvant program to drive growth in the medium and the long term. And I would say that with any franchise the growth expectations in the short-term depend on the data readouts that are coming in the next few months and that's true for us as well. But my confidence is that this is a growing franchise with multiple opportunities for growth and this is what we've modeled as we thought about the total company.

Thanks for the questions Tim. Grey, can we go to the next question please.

Thank you. We can now take our next question from Chris Schott of JPMorgan.

Great. Thanks very much for questions and for additional color on the call. I guess my first question was just going back to slide 11 and that pro forma look at the company, I guess investor are trying to get their hands on the growth of the non-Revlimid portion of the pro forma company. Is there any color you can provide as we look out to 2025, what percent of that pro forma company sales and net income is coming from the non-Revlimid business, so just kind of think about the growth of that piece of the business separated from Revlimid? My second question was then coming back to the Revlimid assumption. I think you mentioned that Revlimid is modeled more conservatively relative to consensus. Is there any more color you can give on those assumptions, I guess specifically how much of a delta versus the street are you thinking about? And is that delta particularly pronounced in certain years over the planning period relative to the other years in that planning period? Thanks so much.

All right, Chris thanks for your questions. I think that we probably can get more too much more color on. I think as it relates to 2025 in particular regarding your question on split between Revlimid and non-Revlimid. We don't go that far out as we talk about [Indiscernible]. I think what you will see in the proxy, you will see the split between the two company sales and you can get a sort of a baseline there. As it relates to how we think about specifically Revlimid versus consensus. Again, I think this is more -- we did multiple scenarios and as I mentioned we did book-ins. There’s a number of scenarios in between. There’s a number of other things that still have to play out both at the District Court level and at that the patent office level, so for us to get into declare at this point I think is premature. What’s important to me, Chris is that, if you look at this slide and if you think about the way we think about the company between now and 2025 we have rapidly growing businesses driven by many of our inline franchises. The opportunity to launch six products in the next two years and a pipeline that will continue to advance and will generate incremental launch opportunities between now and 2025. And then when I think about 2025, we will have not only a business that will have grown, but also we will have a much more diversified company, a significantly higher number of opportunities across multiple diseases to derive the growth of the company in the second half of the decade. So, I think beyond the contribution on the individual components the breath of growth opportunities across different parts of this growth period is what's really complementary and exciting about the new company.

Thanks Chris. Grey, can we take the next question please.

Thank you. We’ll now take our next question from Jason Gerberry of Bank of America.

Good morning and thanks for taking my questions. I guess first question is just for Tom. Just thinking about the upcoming readouts at the ASCO, GU, I’m curious, it seems like the advantage of Opdivo, Yervoy and front-line renal really is the longer-term follow-up survival data versus competitors who likely have immature OS data. So just kind of curious you guys have a longer-term follow-up study. It’s about 30 months of follow-up, but it was about 25-month of follow-up at ESMO 2017. So just kind of curious why this upcoming follow-up isn't longer-term follow-up and what that suggests regarding the durability of the Opdivo Yervoy benefit beyond 30 months? And then my second question is just regarding Revlimid. Have the parties of you guys in Celgene pre-agreed already on what would be acceptable settlement terms with some of the outstanding generic challengers. Just sort of curious how you guys navigate some of the upcoming legal update? Thanks.

Jason, thank you for your question about renal cell. So, couple of things about renal cell. First, we are extremely happy that Opdivo, Yervoy has become the Standard of Care in many settings in the United States. And also very happy that just recently we received our full approval in Europe as well. So we look at that is a great endorsement of the value this combination provides. We look forward to updating survival as we always do with the most recent database lock and we continue to update that data. Now, when I think about this combination, as you point out, I think about something which could be distinguished and again we haven't seen all the data from our competitors yet, but could be distinguished on durability of response. And I think that’s one most important thing to keep in mind that durability of response can play a very important role. And so we look forward to seeing that data emerge and the comparative data sets emerge over time. But also remember that one of the other key things is we also believe that there may be a role for TKIs with IO and we have our study 9ER which will be reading out with Cabo and Opdivo as well looking at that, and that’s a little bit later in the timeframe, later this year. But we look forward to being able to play a role both in across the spectrum of patients with renal cell carcinoma.

Yes. I would just on the Revlimid settlement with generic filers. I think it would be inappropriate about how we are thinking about that other than for Celgene in particular. I would say that we do have consultant sort of perspective or overview with the process with Celgene and the generic filers

Thanks Jason. Greg, can we take the next question please.

Thank you. We’ll now take our next question from Umer Raffat of Evercore ISI.

Hi. Thank so much for taking my questions. So, I wanted to focus on lung cancer for a minute. And maybe just so I understand the regulatory status exactly on what's happening. It seems to me that once the overall survival data and the TMB lows the hazard ratio is about the same as the hazard ratio in TMB highs, maybe FDA was no longer comfortable with TMB to begin with? Is that is that a fair way to think about it? And perhaps is that why there’s sort of now more and more focus on PDL-1 positive cohorts specifically? And on that note, I recall the expectation for overall survival data in PDL-1 positives of 227 was by late 2018 early 2019 and I saw that it's now obviously pushed out and 9LAs pushed out a little bit as well. So I’m just trying to understand the broader dynamic here? And also understand how FDA is looking at TMB and whether TMB ever happening or not from their perspective?

Yes. Umer let me start and then I’ll ask Tom obviously to answer your question in more detail. First of all, as Tom will describe the issue that is important really is the interaction between various biomarkers. I think we’ve been very clear since October that this was a complex file. You've mentioned that the overall survival data we disclosed in October with this respect to low TMB patients and obviously we been in discussions with the FDA on these applications. Tom will give you his perspective about that. If you go there at our lung cancer program, nothing has really changed with respect to the importance of Study 1a, Part 2 and 9LA. We've always said these are event driven trials and the timing is impacted by the evolution of events, but we continue to look forward to seeing the results of this study. It is a broad program and we would see the data. We believe that based on that program we have a real opportunity to play a role in lung cancer. And as I said earlier that's part of a much broader set of opportunities for Opdivo. Tom?

Thank you, Giovanni. Umer, I think just to give you little more emphasis there. I mean, obviously I don’t know what the FDA thinking. I can tell you what I’m thinking about TMB. And I feel that TMB will continue to be important. I think the broad genomic profiling will continue to be important in the way we approach patients with cancer. I just think its early days in trying to understand that. I think if you look at the totality of data, data from us, data that just published last week from Memorial and from Merck. Data from Roche, data from AstraZeneca, whether you’re looking up blood, whether you're looking at tumor, what you see consistently is TMB is a marker for response often for PFS and we don't yet have evidence or data that’s as confirmatory around survival, much of that I would argue is around the way these studies have been designed, data collection and I think it remains a very important part of how we move forward. I want to make one important comment about 227. As you know we believe it's very important to understand the interplay of the various different biomarkers of PDL-1 and of TMB and how they may work together. We know that TMB predicts for PFX benefit in patients who are high TMB with Opdivo, Yervoy compared to chemotherapy, but as you mentioned we also found evidence that the survival trends were very similar whether you were TMB high, TMB low, and to really further understand what that means to be able to give guidance to treating physicians, I think you really do need to see the totality of survival data which will be available hopefully recently shortly with when 1a comes out. One comment just to finish on the timing of data release. As you know these are inherently event driven phenomena and it’s very difficult to be able to predict with exact precision when the events will occur that will trigger the ability to readout. And again, both these studies are slightly prolonged, but again we have to wait for the events to occur and as soon as they occur we will analyze the data.

Thanks for the question, Umer. Grey, can we take the next question please?

Thank you. We can now take our next question from Matt Phipps of William Blair.

Thanks for taking my call. Follow-up to Umer’s question, do you think the subsequent usage of PD-1s in the second line from patients that were high TMB might influence that survival where those chemo patients ended up maybe doing really well in second-line PD-1 and therefore kind of confounded the OS results in particular. And subsequently if Part 1a is positive for the PDL-1 positive patients do you really consider pursuing TMB or would you consider looking at a pan tumor high TMB type of indication similar to the MSI high if you’re really confident of this biomarker?

So, two questions, Williams – Matt, thank you, couple of questions – couple of answers. First is, I do think that PD-1 treatment in second-line makes a big difference and provides great benefit for patients. We've shown that and have led in that area of second-line lung cancer. So I do believe that that can obscure the ability to look at potential survival differences. I think you also to remember that the group of patients who are most likely to develop the most impressive responses are those patients who are high TMB. So -- and I think that true in second-line as well as we show the study 026. So I think that's really important. The second part of your question regarding if 1a is positive how would we approach that from a regulatory standpoint? Giovanni made that really clear earlier when he said, you really have to see where the data takes us. So we have to look at the data, see what the data shows us. As you know we have not seen survival data from Part 1 of the study. So, we need to be able to look at that, to be able determine what’s the best way to determine the patients who get the most benefit and importantly the largest group of patients that we can benefit as well in this setting. So again, really hard to comment on what the regulatory path would be until we see these data sets. I think as Giovanni said, we’ve got three important data sets maturing in the next three to 12 months and we’re going to need to look at the group of them to be able to make the most important strategic decisions from a regulatory standpoint.

Thanks Matt. Can we take the next question please, Greg.

Thank you. Our next question comes from Steve Scala of Cowen.

Thank you so much. What are the dynamics that led to essentially flat Opdivo sales quarter over quarter? And related to that the Bristol business has good momentum, but the 2019 EPS guidance suggest mid-single digit growth X Celgene and growth was further lowered by the Q4 beat. So maybe you could talk about that dynamic? And then secondly, would you like to call out any design differences between the Opdivo, chemo, arm of Checkmate 227 and Keynote-189 that might influence the results. For instance, Roche notes greater chemo dose intensity in power 132 relative to keynote-189 among other differences? Thank you.

Yes. Chris, why don’t you start with performance of Opdivo.

Yes. Thanks Steve. Thanks for the question. So overall sales for Opdivo were quite strong ending the year, while we grew sales outside of the U.S. as you point out and that sales were relatively flat in the U.S., Q3 to Q4. There were couple of unique factors that affected the quarter. First, we had an inventory build in the government channel in Q3 that had to be worked down in Q4. And second we had slightly higher sales in PHS and Medicaid which had a modest impact on gross to net. Those two things notwithstanding, we did actually see demand growth of about 3% for the quarter that was just offset by these other factors. But if you step back from the quarter we actually ended 2018 very much in line with expectations. In the U.S. second-line lung share is holding around 30%. We continue to see the percentage of IO eligible patients decrease, but that's very much in line with what we expected and where we expected to be at the end of the year. We’re holding leading shares in first-line metastatic melanoma as well as in second-line renal cell. And as we look forward we still see growth opportunities albeit more modest in the U.S. coming from adjuvant melanoma as well as first-line renal cell. You’ll recall that we drove rapid uptake in the U.S. in these indications in 2018. We still however see opportunities to continue to grow in first-line renal particularly in intermediate and poorest patients. We've got a great story to tell there in terms of the strength of our OS and as Tom mentioned on the previous call the durability of the data that we’re seeing there. And we’re also benefit from full-year sales in adjuvant melanoma in the U.S. and of course outside of the U.S. we’re still very much in the early stages of the launch of both of those indications. So if you added up we see a good opportunity for growth in 2019 and good momentum globally coming out of 2018.

Yes. Steve, just a couple things and maybe to remind you of one, I would call it maybe one-off item related to our 2019 guidance. So we announced in December the sale of our book of business that we expect to close in April of 2019 that has about 480 million of full-year sales in 2018 and we already indicated that’s $0.04 diluted to us on 2019 basis. We also announced our pension derisking back in November of last year and that shows up in other income, but that's also $0.05 diluted to us in 2019. And then we’ve talked about before that Sanofi alliance income ended in 2018.

And Steve just to answer quickly your question about 227 versus 189, except for the obvious difference which you would note about histology is being different that 227 was [Indiscernible] and 189 was a non-squamous. And except for the fact that the 189 control arm performed particularly less well than some of the other control arms that we've been seeing from both our studies and competitors trials, I think it’s really difficult to make those comparisons. I think we have to really see – until we see what our data 227 look like both from Part 1 and Part 2 of those trials and to see how they emerge.

Thanks Steve. Grey, can we take the next question please.

Our next question comes from Vamil Divan of Credit Suisse.

Great. Thanks for taking the questions. So, maybe one on Celgene and then one other one. So just on the Celgene you obviously see stock was trading quite at discount before the deal was announced. I think the market has not been as bullish on the late stage assets as you are. So maybe just under three weeks you’ve been having a discussion with investors. What do you think that investors are most missing about these pipeline assets? And what should we be getting more excited about? Appreciate the detail on the call, but any further insight would be helpful. And then changing gears to Eliguis. So we saw from Johnson & Johnson relative sales relatively little late this quarter. And obviously there’s lot of volume growth in the class, but just wondering about the pricing side of that equation. So can you just comment on the discount you’re seeing and maybe the impact that the donut hole had enough products this quarter? And how you think about the donut hole will impact next year given your views about -- percentage of the sales covering more sales there? Thanks so much.

Yes. This is Giovanni. Let me just start answering your questions. So first all let me say that we’ve just reviewed in some detail with you some of the key drivers of value of the acquisition of Celgene and specifically with respect to the value of the pipeline assets. If you think about that and as we said in the past we see non-risk-adjusted sales at least for the six assets we discussed today at least $15 billion in sales and we are having good discussions with investors about the strength of the combined company, the key value divers, the opportunity for growth that these assets provide and then obviously the strengthening of the rest of the pipeline.

Vamil, just to add from an R&D standpoint, I just want to share, it’s obviously very hard for you or for anyone to model the particular value of a pipeline assets that’s very early, but I can tell you the enthusiasm that our group at BMS had, if we look at the depth and strength of what Celgene has in their pipeline particular around the concept of protein homeostasis. Chris mentioned earlier the incredible technology that’s been developed in cell therapies that we can – we’ll make a difference. And overall, when I look at this company, I see a company that’s done for myeloma. What we have done for renal cell and melanoma. They’ve absolutely transformed the disease by understanding the biology and by developing treatments, which exploit the fundamental biologic differences, and so there I think you see a lot of similarities between these two companies.

Chris, let me let me touch on Eliquis. So a few points [indiscernible]. Thanks for the question. So first, we’re still very bullish on the business with Eliquis, both in the U.S. and ex-U.S. We grew sales in the fourth quarter 27%. We saw TRx volume was up 36%. In the U.S. we extended our leadership position as the number one OAC across all specialties of indications, and we still have room to grow in the U.S. Outside of the U.S. we’ve seen strength in a number of key markets, notably the U.K. and France. And in fact in France, we became the number one OAC in the fourth quarter. So the base business and the fundamentals look really good across the board. We did see an impact on higher rebates in the U.S. in the fourth quarter, and in Q3 rebates were around 185 million. They increased to 278 million in the fourth quarter. There were two things really driving that. There was a onetime true up of 36 million, but as you point out, we do have a higher volume of patients running through Part D channels and those are highly discounted channels. As we take those dynamics and look forward, I think there are a few dynamics that you need to take into account with Eliquis. First, the donut hole rebate is increasing from 50% to 70% that’s going to put price pressure on that price. Second, we have a differentiated profile and as a result of that, we’ve strengthened our access position in Part D, that is going to lead to higher gross to nets over time. And then importantly, we have significantly increased the volume going to Eliquis. We did that in 2018 based on the strength of the business. We have every expectation to believe that we’ll continue to grow this business in 2019. And that will drive more volume through highly discounted segments, and thus increasing gross to net. What I will say, is in spite of these drags on net price, our expectation is that we’ll continue to grow net sales. And that’s a result of having a differentiated product, good underlying strength in the business in the U.S. and ex-U.S. and frankly the quality of the commercial execution that we’ve seen on this brand.

Thanks, Arnold. Greg [ph] I think we have time for two more questions.

Thank you. We can now take our next question from Geoff Meacham of Barclays

Good morning guys. Thanks for the question. Just have a few. On Revlimid, I think investors are struggling with the erosion curve beginning in 2022, and the pro forma model, and then the pricing environment longer term. So I guess the question is how much value is given for 2121 in earlier lines of therapies, say first or second line myeloma or Revlimid has pretty meaningful share. And then on the first line lung application, does it make sense to wait even longer say for part 2, of 227 or even 9 LA to ensure a broader label, I’m just, I guess I’m struggling with how you balance speed to market and sort of data differentiation in IO versus science behind TMB versus PD 1 better? Thanks.

Thanks. Let, let me. Sorry, Geoff, let me answer your first question. So as we’ve discussed bb2121 and other assets, our current forecast includes the lead indication, in that case obviously we see significant potential for further expansion into earlier lines of therapy.

And Geoff, just to come in on the first line lung application obviously we want the speed-to-market is important. I think you’re right, or and bring up a very good point that we want to see what the data shows us, and that will really determine how we proceed from a regulatory standpoint. And you know, I just want to emphasize that part 1 A, part 2 and 9 LA are three distinct separate studies. And it may be that we get a very strong signal from one of them, that allows us to proceed with a regulatory filing. So I think we’ll have to take that and follow the data as you point out.

Thanks Geoff. We’ve got our last question please Greg [ph].

Thank you. Our last question comes from David Risinger of Morgan Stanley.

Yes. Thanks very much. My first question is just a follow up on Eliquis, and thank you for the color. I think the comment was that you expect growth going forward, but I believe the Street expects substantial growth going forward. So could you just provide some level of color on the outlook for growth relative to the growth that you reported in the fourth quarter for Eliquis. And then second, pivoting to novel I-O pipeline candidates, that was mentioned earlier in the call. Could you just discuss if there are any key readout to watch in 2019?

Thanks very much, David. Thank you. This is Giovanni. So let me just start. As Chris said earlier, we are very bullish on Eliquis. Performance is strong around the world and particularly in the U.S. there is strong momentum in the brand. It’s one of the key growth drivers for the company. So let me just reiterate we’re very bullish on the prospects for the asset, and Tom on data readouts.

And Dave, a couple of things on data readouts. First, when you think about what we have in the established products looking up David, we’ve talked in detail about lung cancer. We do know that we’ve got data reading out this year in Hepatoma and possibly some data and mesothelioma and head neck later in the year. You specifically asked about novel compounds, so and I think that’s an area of great excitement from ours -- from our standpoint. First, we hope to have some data later this year with our lag 3 compound to get a better sense of how this unique molecule that approaches that concept of lymphocytes exhaustion might be able to play a role in cancer. The second is you’ll see more evolution of data with our combination between OPDIVO and Nektar as the year progresses. We’re very excited about the potential for this combination to be able to improve outcome and provide a unique therapeutic opportunity for patients. And then again, CTLA-4 is a really really important compound and its important target. And so the two compounds that we’re excited about are the pro body that we’re doing with CytomX as well as the both of which are moving through phase I this year. In fact this year, we hope to advance a product compound close which would be the pro body of the non-fee cost related formulation. So again, combining those two technologies looks particularly exciting. So a number of important early signals, I would say from some of our novel I-O agents, and then of course we talked earlier and you saw the slide, slide 15 in the deck which looks at the timing of some of the established readouts which we look forward to in the next 12 to 24 months.

Thanks Dave. Turn it over to Giovanni for some closing comments.

Thank you John and thanks everyone. So as we close let me just reiterate this was a very good quarter in which capped a really great year. Our performance was driven by strong commercial execution with good momentum in the business going into 2019. We’ve made important progress in our pipeline and we have demonstrated disciplined management of our P&L. And these will create a strong foundation as we enter into 2019. This will be an exciting next chapter for our company as we plan on the integration of Celgene and I’m confident we are creating value for BMS as shareholders. I’m excited about the prospects we had, we have as a leading scientific company, and I want to thank everyone for participating in the call. Thank you.

Greg. I think that concludes our call.

This concludes today’s conference call. Thank you for your participation. You may now disconnect.