Good morning and welcome to the BioXcel Therapeutics Second Quarter 2022 Financial Results Conference Call. At this time, all participants are in a listen-only mode. [Operator Instructions] After the presentation, there will be a question-and-answer session. [Operator Instructions] Just to remind everyone, certain matters discussed in today's conference call and/or answers that may be given to questions asked are forward-looking statements that are subject to risks and uncertainties related to future events and/or the future financial or business performance of the company. Actual results could differ materially from those anticipated in these forward-looking statements. Risk factors that may affect future results are detailed in the company's quarterly report on Form 10-Q for the quarter ended March 31, 2021 which can be found at www.BioXceltherapeutics.com or on www.sec.gov, which will be updated in its quarterly report on Form 10-Q for the quarter ended June 30, 2022. As a reminder, today's conference is being recorded. Joining us on today's call are Dr. Vimal Mehta, Chief Executive Officer; Richard Steinhart, Chief Financial Officer; Matt Wiley, Chief Commercial Officer; Dr. Rob Risinger, Chief Medical Officer of Neuroscience; Dr. Frank Yocca, Chief Scientific Officer; and Dr. Vince O’Neill, Chief Medical Officer of Oncology. It is now my pleasure to turn the call over to Dr. Mehta, the CEO of BioXcel Therapeutics. Please go ahead.

Thank you, operator. Welcome everyone and thank you for joining our call today to discuss BioXcel Therapeutics financial performance and business highlights for the second quarter of 2022. It has been a busy but rewarding few months. And we have been -- we have many exciting updates to review this morning. As you know, we are a biopharmaceutical company utilizing Artificial Intelligence approaches to develop transformative medicines in neuroscience and immuno-oncology. You have heard me discuss our five year vision to become the premier AI driven neuroscience company and our progress from this past quarter across all parts of our business continues to bring us closer to this ambitious goal. Let me begin by highlighting our notable achievements across the organization. We have laid the foundation for a successful entry into the market for IGALMI, our FDA approved acute treatment for mild, moderate or severe agitation associated with bipolar I or II disorder or schizophrenia in adults. Our sales team has been in the field for over two months and key commercial activities are in full swing to create awareness and drive eventual adoption. We trade launch in early July, our priority remains delivering this new treatment option to hospital system, healthcare professionals and patients. Our Chief Commercial Officer, Matt Wiley will discuss commercial progress and early feedback from the field in more detail shortly. While IGALMI trade launch marked an important milestone for the 501 program, we continue our heavy focus on our three pillars portfolio expansion strategy for the franchise. Let me summarize our progress since last quarter. Following a successful Type B meeting with the FDA, we have further executed our strategy for our first strategic pillar, which is broadening the medical settings where 501 can be offered. On this front, I'm excited to announce our SERENITY…

Thank you, Vimal and good morning, everyone. I'm pleased to report our progress on three fronts this morning. Our early market access momentum, key learnings from our initial field force efforts and our commercial strategy and execution. The market access activities are progressing very well and are on schedule. While the contracting timeframe with group purchasing organizations or GPOs can take six to nine months on average, we have been encouraged by our early engagement. There are three national GPOs that represent over 90% of the beds and our 1,700 targeted hospitals. And we are in various stages of discussions and negotiations with each. We expect to finalize the contracting process over the next few months and we'll share our progress with you when these relationships are complete. In addition to national GPOs, we've engaged with integrated delivery network hospitals or IDNs to drive further downstream adoption of IGALMI. We have also executed the CMS contract and completed the federal supply schedule submissions to unlock access to state and VA hospitals respectively. We've completed the first phase of our commercial build out and deployment of our sales personnel in the highest priority targets. To-date, our field force is successfully engaged the majority of their target hospitals, and has made progress in P&T formulary review discussions. Multiple hospital systems and IDNs have indicated their interest for the product and expressing intent to review. As a P&T committees review IGALMI in their scheduled meetings during the second half of this year, we will provide an update with more specific metrics. We've learned a lot since the field launched 10 weeks ago. The early response to our awareness activity, sales messaging, and IGALMI concept for which there is no commercial precedent has been starkly positive, and has revealed tremendous opportunity within the bipolar…

Thank you, Matt. I will now review our second quarter 2022 financial results. Research and development expenses were $17.9 million for the second quarter of 2022 compared to $13.9 million for the same period in 2021. The increase in R&D expenses were primarily attributable to clinical costs related to the company's TRANQUILITY program. Selling, general and administrative expenses were $18.4 million for the second quarter of 2022 compared to $14.1 million for the same period in 2021. The increase in SG&A expenses were primarily due to personnel and costs related to the launch of IGALMI in the U.S. BioXcel Therapeutics reported a net loss of $37.7 million for the second quarter of 2022 compared to a net loss of $27.6 million in the same period in 2021. Cash burn for the quarter was approximately $33 million, which includes approximately $700,000 in inventory costs and $3.6 million in prepaid clinical trial fees. As of June 30, 2022. cash and cash equivalents totaled approximately $233.5 million. This excludes $30 million of contributions from the $260 million strategic financing announced in April. To-date the company has met the milestones and has received $100 million from that agreement. Now I'd like to turn the call back to Vimal.

Thank you, Richard. We would now like to open the call for questions. Operator?

Thank you. At this time, ladies and gentlemen, we will be conducting our question-and-answer session. [Operator Instructions]. Our first question is coming from the line of Greg Harrison with Bank of America. Please proceed with your question.

Hey, good morning, guys. Thanks for taking the questions. Maybe to start out, could you provide some more color on the ex-U.S. strategy. Maybe just talk a little bit about the drivers behind the decision and how you would characterize the discussions that you've had with potential partners?

Regarding the ex-U.S. strategy, it has been evolving considering that our program is evolving really fast. And U.S. opportunity is so attractive in a short run with our recent announcement of the SERENITY III program where our drug is already approved IGALMI, it can go to the home setting. Alzheimer's program is progressing, and we will be ready to file SNDA in that program after completion of two pivotal trials. So opportunity in U.S. is really large. In addition, we are pursuing MDD, it's a strategic choice on resource deployment, shall we focus on U.S. or continue to focus both in U.S. and outside us. So once we have captured opportunity in U.S., then we will start deployment of strategy outside ex-U.S. And our goal will be to look for a partner who can cover multiple geographies rather than originally we were thinking of just like looking for a single partner in Europe. Now Japan is a very attractive market considering the Alzheimer's related agitation, and we are very strong IP positions. So we are making strategic choices just from a resource deployment perspective. Otherwise, opportunity is very attractive outside U.S., in addition to U.S.

Okay, that makes sense. And then maybe just one more, maybe an update on the IGALMI launch. Have you seen any early adopters in the month or so since trade launch? And if not, when would you expect the first to start to come on board?

With the process, Greg. First of all, thanks for the question. The process takes six to 12 months on average to just get the formulary approval in the hospitals. And so driving adoption typically happens after that process has been completed. So the steps that we're taking now that we've been taking over the last 10 weeks is to drive interest, identify P&T stakeholders and begin the process to get formulary adoption in those hospitals. Once that happens, we'll see swifter uptake, but this is how typical hospital launches proceed. It's an operational fact. And we're just working within that set of facts.

Got it. Okay. Well, thanks again. And congrats on the progress.

Thank you, Greg.

Thank you. Our next question is coming from the line of Robyn Karnauskas with Truist Securities. Please proceed with your question.

Hi, thanks for taking my question. And again, good work on the progress. So on SERENITY III, why not -- why just 60 milligrams. Can you repeat those? And what percentage of the population might that exclude that would need a higher dose? That's my first question, then I have a follow-up.

That's a great question, Robyn. 60 microgram, as you know in our previous dose escalation study, we saw that 60, 80, 120, 180 they were all effective. We starting with 60, because that's a dose like, most relevant in an outpatient setting and I'll have Rob outline why we chose 60 microgram dose drop.

Sure. So we chose the 60 as Vimal pointed out, because we actually have data on 60 micrograms from our dose ranging study in schizophrenia. It separated from placebo at two hours. It has as a large proportion of patients who respond to 60, so the number that might, let's say, need another dose is very small. So the trial is designed, it's a, frankly very slick design, we're demonstrating the efficacy, and almost an identical population, it will be a combination of schizophrenia and bipolar disorder. It will be done at the very same sites that completed SERENITY I and II. So we expect identical results in terms of an improvement from baseline and the PEC total score at two hours. And then we're testing it for safety purposes at home, which we've received agreement from the FDA that this is a pivotal trial and will allow us to expand the label for this same indication, if you will agitation associated with schizophrenia or bipolar disorder, but at home use.

And so just to be clear, can you repeat those and is the first portion just in the hospital and then second portion at home? Or is it all at home and just the second portion is more for safety?

The first portion is identical to what we've done in SERENITY I and II, it will be acutely agitated patients who present in an acutely agitated state. We will be able to demonstrate the 60 microgram dose as efficacious. And then the second portion of the study is testing the safety at home.

So the first portion is in a hospital setting?

Yes.

Just want to be clear.

And Robyn there is a reason for it, because we are using PEC score. And it's a lot more convenient to have a PEC score rated by some experts, rather than at their home setting. And that's what the reason we split the two phases.

Ridges, the PEC score was what we've already demonstrated.

Okay. That makes sense. And then the second question I have is regarding the impact of the health care reform bill, I mean, obviously, if you sell this drug significantly, and Alzheimer's, it's a rather large Medicare population. And by nine years after launch, you could be outside of that small biotech exclusion criteria. But are you within the 50 top drugs in Medicare? Have you thought about how we should think about. I guess the first question would be, what is your estimate split for Alzheimer's for Medicare in the United States? And if you thought about how we should model that given it out, that's now going to look like it's going to be in law?

So the med D provision in the graph bill is really focused in on those drugs that are already costing CMS billions of dollars. So that's where the negotiations are going to happen first. We -- so to answer your question that the Medicare portion of Alzheimer's opportunity is roughly a third of the total opportunity that we've seen in our modeling. And we would expect that, we would address these potential issues down the line as we're thinking about for instance, pricing flexibility that we've communicated in the past and how we want to approach this particular market. The fact is, we've got a long way to go to get to FDA approval, and thinking downstream about a bill that has not yet been ratified is a little premature.

Okay, great. Thank you.

Thanks, Robyn.

Thank you. Our next question is coming from the line of Sumant Kulkarni with Canaccord. Please proceed with your question.

Thanks for taking my question. And sorry for any background noise. I have a couple. The first one is uncertainty three, on the safety aspect. What exactly do you plan to collect in terms of metrics for the atom use component?

Thanks, Sumant. It's Rob Risinger. The metrics for adverse events, for example, would be collected as you collect adverse events in any trial, the patients will be collecting adverse events at the time of dosing. There will be reliable informants will say maybe a caregiver or maybe a spouse, maybe a family member, son, daughter, whomever will be there to also report adverse events and they'll report these to the investigators. So the adverse events are collected identically to how you might study adverse events and other trials as an outpatient. Patient comes into the office and says, this is what happens. This is how I felt and investigator records that.

Right. And then my follow-up is given that the label currently does not restrict use of IGALMI to a specific setting. Is there anything that precludes a physician from sending a patient home with today as there?

Sumant, that's a great question, as you said label focuses on under the supervision. So wherever there is a supervision available, IGALMI we believe can be used. We're just focusing in the hospital setting because two-thirds of the patient out of 25 million episode comes to the hospital market. It's a very well defined and focused approach, how physicians will use it, once they develop experience, all of that will unfold in next six to 12 months.

Thank you.

Thank you, Sumant.

Thank you. Our next question is coming from the line of [indiscernible] with Jefferies. Please proceed with your question.

Hi, team, this is Commis on for Chris. What's the significance of interim use for SERENTITY III, do you anticipate that bring outpatient completely as a second indication, regarding clinical meaningfulness and Alzheimer's agitation and psychosis, was there -- what gives you confidence in your endpoint and interpretation is clinically meaningful and then for lastly for your MDD trial, what are the drivers for dose selection in that?

Thank you for your questions, I will pass it on to Rob to answer both the TRANQUILLITY program as well as then follow-up with MDD.

Sure, so let me be clear, it's the same indication in SERENITY III, this is acute agitation episodes associated with schizophrenia or bipolar disorder. And so we believe that using IGALMI for episodes that aren't just in the hospital or just directly in front of a health care provider, but enabling the patient to take this when they're agitated at home, could potentially even prevent the patient from requiring hospitalization or going to the emergency room or running to a clinic. So it's exactly the same indication, but there's tremendous value to the patient and the people around the patient to sort of prevent an escalation from occurring. And then the second piece is that why a patient end up in the emergency room, because agitation is a spectrum, mild, moderate, and severe, it escalates. So if you are preventing the agitation when it's in early stages of mild stages at home, it's very different than these patients will not need to go to the emergency room. So I think it's a dynamics between the institution, the reason patient end up there because they don't have a choice, or no treatment options at home. So that's why they end up two-thirds of the patient in the institution. And if IGALMI is available, and when they're back scores are lower compared to when they end up in the emergency room, you could treat these patients with the dose we have selected.

So with respect to the major depression and dose selection, we're testing the tolerability and of course safety of escalating doses, both escalating individual doses and dosing at more than once a day for example, dividing doses a morning and an evening dose, for example. And so the tolerability is really important prior to testing this in a proof-of-concept study for depression. So those are the sort of very simple biomarkers that would enable us to select a dose, how well is it tolerated? Are there any safety issues, and thus far we continue to escalate patients.

Thank you. We'll move on to our next question, which is coming from the line of Yatin Suneja with Guggenheim. Please proceed with your question.

Good morning. This is Eddie on for Yatin. Thanks for taking our questions. Congrats on all the progress. For the at-home expansion program in SERENITY III and Part 1 what would be a reason why a patient wouldn't proceed at-home dosing does the company or experts you have spoken to or regulators have some safety bar for what would need to happen to ensure a patient can safely move to at-home administration? And then would there be a limit to the number of doses a patient can take in Part 2 and then for the MDD program, given the rapid onset of action you saw for agitation, would you expect to see a rapid onset of antidepressant efficacy? And what are the earliest time points you're looking for efficacy in this study?

So thank you. So the patients in SERENITY III, the first portion will be dosed with either placebo or the 60 microgram dose, those patients are independent of the patients in Part 2, Part 2 is testing the dose at-home. It's not a gateway. So I realized that your question implies that you think a patient is going to start with Part 1 and continue to use it at-home, that's not what we're doing. The first part of the trial is patients who are acutely agitated, they present with agitation, and we're treating it with the 60 microgram dose. So we'll have very accurate deed, if you will, on efficacy, as well as safety in a tightly controlled situation, where everything can be monitored, just as if you were in the emergency room. The second part of the study is entirely at-home in a whole different set of patients. So again, we will have enough data, the FDA has said that they will consider this a pivotal trial for the indication at-home.

So there were no safety concerns, or any reasons that we could not do the first portion in at-home setting, as I mentioned previously, it's all about having the robustness of the data and using the scale that we have used in SERENITY I and II, and we were able to use this and at the same time demonstrate the safety at-home, so that it can become a package to for label expansion or for another SNDA.

Got you, that's helpful. And then on efficacy?

Sorry, say that again please.

The MDD study, if you could talk about what the earliest time points are going to look at for antidepressant efficacy and whether that would be similar to what you'd see for agitation?

In MDD, we're not looking at one or two hours, we're looking at the days and weeks, efficacy in MDD we expect to see very early but remains to be seen, we'll be likely testing this within the first week, second week, et cetera and we're not just looking at the acceleration of antidepressant response. We're also looking at the proportion of patients who improve, we know that SSRIs are not the be all and end all for example, antidepressants don't work for everyone. Maybe they work for a large, a large proportion greater than 50%. But we'd like to greatly improve that. So we're looking at both acceleration and responders or response overall, when treated with BXCL501.

And this study is going to have four weeks or something like that right treatment?

Daily dosing over a period of four weeks.

Thank you, we'll move on to our next question, which is coming from the line of Colin Bristow with UBS. Please proceed with your question.

Hey, good morning. Thanks for taking the questions. I guess as we think about subsequent quarters where you're going to report revenue, can you just give us any details around how revenue will be recognized is that when orders are made, or shipped and received? So that's question one, question two sorry if I've missed this but let's say TRANQUILITY II timing slipped a little from ended this year to first half of May, just curious to what's the rationale behind this and in terms of any details or anything you can give us on the other assets moving into that? Thanks.

This is Richard, on the sales we're going to recognize sales when it's sold to the final customer through the hospital, that's where we actually will recognize sales.

Okay, great.

And regarding the TRANQUILITY program, we are conducting this trial in ALS, where the elderly patients reside and in residential setting, and we have observed COVID disruptions sometimes in these sites, and that restricts access for CRO to go into the elderly center. And we don't know what could happen in next several months in the Fall with the COVID. So we are just being cautious and providing a guidance that there could be slip on the data readout because of those reasons. In terms of operational aspects, we are not seeing any issues in terms of number of patients that are there. These are elderly patients, they are frail, so you do get little bit more screen failures, and you will get it in that SERENITY trial, because those are younger patients. So I would say those are the reasons nothing very specific except COVID related delay, or you can get more screen failures because the patients are frail and they may have some other associated medical complication, and they can get excluded.

Okay, great. Thank you.

And you had the third question, was it related to MDD or our, I just want to clarify?

Just in terms of the -- when do we get more information on your other assets for the somewhat under moving stealthy forward?

Sure. So that asset is now going through the formulations. We expect that work to complete. And then once we have done all the like preclinical workup and we are ready to take to the clinic, we will disclose what that asset is which indications we are choosing. Initially, we have mentioned that like one of the indication where it fits in very well is chronic agitation in treatment of chronic agitation and dementia. But we continue to explore additional options where the mechanism will fit in and we will lay out the plan in 2023.

Great, thank you guys.

Thank you, Colin.

Thank you. Our next question is coming from the line of Graig Suvannavejh with Mizuho. Please proceed with your question.

Good morning. I hope everyone's having a fantastic day. This is Richard Allen for Graig Suvannavejh who is tend to be best. And it's great to be back on his name. So my first question goes on to SERENITY III plan. How large do you expect the study to be with a goals enrolling how many patients and by when do you expect them. And my second part of that is that what do you think of the incremental increase to revenue since a third of episodes occur outside of institutional settings? Can we assume a 30% increase to peak revenues or what was the company's state? Thank you.

Thank you, Richard, for those questions around the SERENITY III. First question, I will pass it on to Rob so he can outline he's agreeing on number of patients and everything. But we expect this trial to be pretty short. Just to remind everyone, our both trials SERENITY I and II had 750 patients, 375 each. And three arm study there we were testing two doses and a placebo. And we completed the enrollment in about five months or so. So these are very fast trial in terms of the timing. And in terms of the number of patients, I will pass it on to Rob, because he is currently doing powering studies to make sure we power the study to Rob.

So each portion of the study the first and second half will be well under the -- I believe was 350 patients in SERENITY I, 350 in SERENITY II. So because they're independent patients are essentially in a way independent studies, we know that these will enroll relatively quickly. In addition, this there's no exclusion, so unlike SERENITY I and II, SERENITY I was patients with schizophrenia. SERENITY II was patients with bipolar disorders. We're mixing that and the FDA has agreed that we can test this in both patients with schizophrenia and bipolar disorder at the same time in the same study, because our effects are similar. Humans are humans, regardless of what the underlying illness is and thus we expect an even faster enrollment. We don't anticipate any problems with recruitment for this agitation is relatively common. And we were able to enroll both the SERENITY I and II very rapidly, even in the midst of the major part of the COVID pandemic.

So Richard, we will provide a guidance once we roll out the plan -- pivotal plan, that when the data readout is expected, but it will certainly be in 2023, and we'll provide more granular guidance on first half or second half.

So, Richard, this is Matt, just to take your question on revenues for the community setting. So, the math that you're calculating here is correct in that there are roughly a third of the agitation episodes in the community setting. But one of the things that we've learned in recent market research is that specifically in the bipolar population, which represents the majority of agitation, we see approximately 10 additional episodes that are not captured in the claims data. So this is roughly a 60% increase in what we previously thought the community setting opportunity was. These episodes we're not seeing in the schizophrenia patients. And typically when they're compliant with their anti-psychotics, it would suppress the agitation episodes. So it makes sense, identical to what we saw in claims. But in bipolar those 10 well called shadow episodes are being managed through meditation, exercise, illicit drug use alcohol. We believe that those are opportunities for 501 should we get the approval for that indication.

Great, thank you. So then, and you also mentioned that IGALMI exceeded expectations in their value proposition. What do you think the uptake curve should look like for a IGALMI then? Are you comfortable with where consensus is currently? Or do you see that shifting?

So there's a -- as I said, there's an operational or mechanical process to unlock the value and uptake in hospitals. And we still have to deal with that process. However, the early signs have been very encouraging, the interest in the drug is very encouraging. And we see things moving in a very positive direction. So I wouldn't see that impacting the uptake curves near term just because of the mechanics of getting drug on formulary and unlocking the potential for demand. But once that's behind us, I see a big opportunity and helping a lot of patients.

And we continue to see a lot of face to face meeting. Our sales teams are getting a lot of face to face time, despite the COVID or any other reason. And they're getting very positive feedback, as Matt said. It's all very encouraging. In fact, whatever we were thinking this drug potential will be now being in the marketplace for 10 weeks. We are even more excited about.

Great, thank you so much.

Thank you, Richard.

Thank you. The next question is coming from the line of Ram Selvaraju with H.C. Wainwright. Pleased proceed with your question.

Thanks very much for taking my questions. Just here wanted to ask if you could submit this information regarding the regulatory process for the indication for the user statement of IGALMI within the context of what you are trying to capture with certain degree. So if SERENITY III proved to be positive, what we should thinking about with respect to a regulatory [indiscernible] view period. And also if you could comment on any intent on your side with respect to doing any exploratory clinical work in generalized anxiety disorder, if any? Thank you.

Thank you, Ram. So Rob you…

And so, Ram, we would expect once the trial is complete to be able to put together a package for a supplemental NDA application very rapidly within a few months. And the review timeline will depend on the FDA, of course, we could request for example, fast track on the basis of several findings, which we fully anticipate should have robust efficacy and similar or even better safety than what we have been approved with 120 and 180 microgram doses. And so that regulatory process, we can certainly outline in a future discussion, but we really need to get this data. We believe we'll have the data relatively quickly, because we're enrolling all comers if you will with schizophrenia and bipolar disorder, and then we can provide more clarity and an update in the future. With regard to additional indications such as generalized anxiety disorder, we are planning studies to look at a variety of or potential indications, if you will, putting our toes in the water for indications like generalized anxiety disorder, we could look at any anxiety disorder, panic, PTSD -- excuse me, acute stress disorder might even look at developmental disorders. We've had a lot of discussions with, in fact, investors who have said, well, why aren't you studying this in autism, for example. And so we have plans to do basket studies. These are studies where you take small numbers of patients and sort of preliminary, they tend to be open label studies, and you just determine if there's a signal or not, they're cheap, they're fast. And they are a way for us to give a certain directionality to the next steps in development. But let me point out that our focus has been and continues to be primarily on the expansion to at home use to demonstrate utility efficacy and safety and Alzheimer's disease and agitation associated with Alzheimer's and major depressive disorder. These will be the next if you will for IGALMI.

Thank you.

Thank you. Our next question is coming from the line of Corinne Jenkins with Goldman Sachs. Please proceed with your question.

Hi, how should we think about your pricing strategy for potential indication expansion to include as needed or chronic dosing of economy? Thank you.

Yes so. As we think of further downstream indications, we continue to have flexibility in how we might think about pricing in those settings. We haven't made any determinations yet. We'll still continue to monitor the market, per the previous question around legislation and things of that nature, we'll watch the market dynamics closely. And we'll make a decision on pricing to best fit the markets that we're going into. Surprise to say that we have a very smart pricing strategy now in the institutional setting, and that may actually fit future downstream indications. So while we'll continue to monitor and make that decision as if should we get approval for those indications? And at the time that we entered those markets.

Sure, thanks. And could you also please confirm how many doses of IGALMI are you expecting patients to receive in part two of this SERENITY III trial? And for how long will you be evaluating the patients?

Patients will be using the BXCL501 at home when they have an episode of acute agitation. And so we're giving the film and monitoring them over a period of months. So that we pick up the frequency and what happens when they use the film. Patients because it's placebo controlled patients are able to take if you will rescue medication, that will be very much an individual thing. Patients do take additional medications at home to attempt to treat their anxiety. They obviously also take alcohol or marijuana, try meditation. There's a lot of things that they take, but principally, we're testing the effect of a single dose of the BXCL501 that 60 microgram dose, and there is a possibility for an additional dose, but that would -- that will have to be up to the patient as to whether or not they're feeling something from the initial dose and calming.

Sure. Thank you.

Thank you. It appears we have no additional questions at this time. So I'd like to pass the floor back over to Dr. Mehta for any additional concluding remarks.

Thank you everyone for joining us today. We look forward to connecting with many of you in the coming weeks, including at the Canaccord Growth Conference, where Matt and I will be hosting meetings and participating in a fireside chat. Have a great day.

Ladies and gentlemen, this does conclude today's teleconference and webcast. Once again, we thank you for your participation and you may disconnect your lines at this time.