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Compugen Ltd. (CGEN)

Q3 2012 Earnings Call· Mon, Nov 5, 2012

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Transcript

Operator

Operator

Ladies and gentlemen, thank you for standing by. Welcome to the Compugen Ltd., Third Quarter 2012 Financial Results Conference call. All participants are at present in a listen-only mode. Following management’s formal presentation, instructions will be given for the question-and-answer session. (Operator Instructions) As a reminder, this conference is being recorded, August 7, 2012. With us online today are Mr. Martin Gerstel, Chairman of the Board, Dr. Anat Cohen-Dayag, President and CEO and Ms. Dikla Czaczkes Axselbrad, CFO. I would like to remind everyone that the Safe Harbor language contained in today’s press release also pertains to all content of this conference call. If you have not received a copy of today’s release and would like to do so, please contact Dikla Czaczkes Axselbrad at 972-376-585-95. Mr. Gerstel, you canbegin.

Martin Gerstel

Management

Thank you very much. On behalf of my associates, all the employees of Compugen, welcome to our delayed Q3 2012 conference call. Thanks for joining us. First, for those of you and your families who were impacted personally by the devastating storms last week affecting the eastern United States, we hope you are fully recovered or at least are on the way to full recovery and our best wishes are with you. Less than three years ago, Compugen selected Fc fusion and monoclonal antibody therapeutics for oncology and immunology as our first areas of focus. The results since then, which were largely achieved during the past two years, have been more than impressive and almost certainly unprecedented in the pharma industry and are now conclusively demonstrating to leading companies in the industry the power of the unique, predictive, discovery infrastructure that has been established at Compugen. Today, we have an internally discovered Pipeline of about 30 candidates for targeted medicines in key areas of significant unmet medical need and high industry interest, about half of which are moving forward with priority validation and development. In addition, during this time period, we have successfully integrated in-house expertise and development capabilities for both arms of our pipeline, while maintaining and enhancing our computational discovery leadership. However, as a pioneering company in an area with a history of failures by many others, in order to attain success as a public company, Compugen requires the positive recognition of three important audiences; he scientific communities, the pharmaceutical industry and the financial community and most certainly in that order. With respect to the scientific community, this recognition begun to be achieved from our earliest years as our scientists made important breakthroughs in the predictive understandings of key biological phenomena at the molecular level such as alternative…

Dikla Czaczkes Axselbrad

Management

Thank you, Martin. As Martin mentioned, our financial results for the quarter were in line with our expectation. However, there are a few items that deserve further explanation. The approximately $100,000 in revenue for both the third quarter of 2012 and the nine months ending September 30, 2012, represent a payment of certain research activities we performed for our joint venture with Merck-Serono that was announced in June this year. The net loss of $8.3 million for the nine months of 2012 compared with $7.7 million for the first nine months of 2011 include $1.3 million in non-cash charges related to the complicated accounting required for the basic arrangements, compared to $800,000 in the first nine months of 2011 for this arrangement. The reported increase of about $1.9 million in R&D expenses net for the first nine months of 2012 is largely due to establishment and initiation of activities at the South San Francisco facility as well as increasing level of activities in the company’s pipeline program. Higher pipeline cost involved independent investigated and service providers performing evaluation studies and an increased usage of lab material. Increased R&D expenses also reflect the impact of low governmental grants compared with 2011 given that such grants are deducted from research and development expenses. This increased level of R&D activity and in particular the establishment and initiation of activities at the South San Francisco operation also explained the increased level of fixed assets at the end of the quarter. With respect to our current cash status, we ended the third quarter of 2012 with approximately $20.1 million in cash and cash related account. This total of $20.1 million does not include $5 million due to be received later in 2012 under the second phase research and development funding arrangement, or the montage value of our Evogene shares. In addition, Compugen continues to have no long term debt other than the book liability associated with the research and development funding arrangement. And with that, I will turn the call over to Anat.

Dr. Anat Cohen-Dayag

Management

Thank you Dikla. As Martin mentioned, less than three years ago, Compugen selected protein therapeutics, namely Fc Fusion and monoclonal antibodies for oncology and immunology as our first areas of focus. In my prepared remarks today, I would like to provide you with an overview of our product related accomplishments since then in terms of both quantity and quality. We are now receiving clear and positive feedback from major pharmaceutical companies in terms of appreciation of and interest in both our unique discovery capabilities and our leading product candidates. Since we have a high degree of confidence that this will result in the type of validation required by the financial community to properly value both our pipeline and our company, we believe it is important for us to communicate these achievements to our shareholders. Primarily during the past two years, we have pursued validation of our product candidate in parallel with early stage development activities involving our prioritized list of candidates. This has included numerous experimental studies supporting the progress of the execution program and its respective antibody target program. These studies performed both in-house and by our network of collaborators, included this cord test to demonstrate that the novel molecules has the predicted activities and specifically for the Fc Fusion, multiple in vitro experiments using these animal models that the industry relies on to validate these product candidate. Our average rate of success for all of these validation studies has been far in excess of 50% demonstrating conclusively the following accuracy of our predictive capabilities. For example, the fact that five out of the six Fc Fusion product candidates based on our novel B7-like prediction, have shown positive results in relevant autoimmune disease model has been referred to by several experts in the field and potential pharma partner as…

Operator

Operator

Thank you. Ladies and gentlemen, at this time we will begin the question-and-answer session (operator instructions). Please stand by while we pool for your questions. The first question is from Mara Goldstein, of Cantor Fitzgerald. Please go ahead. Mara Goldstein – Cantor Fitzgerald: Thanks very much. Can you hear me?

Martin Gerstel

Management

Yes. Mara Goldstein – Cantor Fitzgerald: Great. Just briefly on the San Francisco operations. I am just wondering about the status of staffing there. Just thinking back to the last conference call and discussions of adding personnel there. And I am also interested in the checkpoint inhibitor program. And given this area is incredibly busy area and lots of interest in these programs on the part of the pharmaceuticals and clinical development. Well, I’m just wondering what your thoughts are in terms of how far to advance what you have before looking to monetize it for the partner.

Anat Cohen-Dayag

Analyst

Okay. So it relates – first, to your first question about our San Francisco subsidiary. We’ve started discussing. We are almost done with it. Most of the staff is there already, started to work. Work was initiated full steam ahead and couple of drug charges that were already transferred from Israel to Inc and we are very happy with the first results that were seeing. As I stated we already have two programs that are showing some heat with antibodies from the three that we’ve initiated. With respect to checkpoint proteins, it’s a very good question. There is the real hype in this area as I stated in my remarks mainly due to the BMS results that were published in last our co-meeting in June and this gave such a boost to this field. Of course there are a couple of companies that already have started the generation of antibodies to non-target, mainly working on PG1, PTL4 which are known immune checkpoints, which were discovered long ago. By the way we were using this an in-check point also in our discovery effort in order to find, tune our discovery parameters and to make sure that we are discovery stuff that is on one hand belong to this family but on the other hand maybe differentiated from this immune check points, and it is currently a field that is moving fast. We feel that we were able to come up with this discovery at the right point of time with respect to the fact that we are not now at a stage of just making the discoveries, we have made them some time ago. We already have packages that are showing, starting to show the superiority of this molecules as compared to other molecules that are in the public domain that are not in development at all even and for molecules that are in development. By the way, not all the molecules could serve as therapeutic entities. They are molecules that are in the public domain and we feel that the packages that we have generated up till now, specifically for CGEN-15001 are of interest. We are very happy with the results that we are getting with the differentiation and superiority profiles that we could generate and while moving forward, full steam ahead in terms of R&D plans, we are in discussions with the Pharma companies around leading candidate but definitely this is a good time for us to be with this programs all the time.

Martin Gerstel

Management

Just to add from – it really is an excellent question because we must in answering that question internally; we have to take a number of factor into consideration. For example, we know that the for whatever reason the shareholders are waiting for quote ‘the first collaboration to be announced’. And so we have to take that into consideration and we are fortunate in that we have a number of molecules, it’s not just the typical one or two and this – so we have really a wealth of product candidates. But behind your question is the well-recognized understanding that as the further you take a product in development before you license it out you can see some very substantial increases in the returns that you get. So there clearly has to be a balance amongst these different factors and we’ll deal with that and we are dealing with that as we are continue these negotiations with the various companies that we are talking with. Mara Goldstein – Cantor Fitzgerald: Okay. Thank you. I really appreciate the color.

Operator

Operator

The next question is from Brett Reiss, of Janney Montgomery Scott. Please go ahead. Brett Reiss – Janney Montgomery Scott: Hi. Can you hear me?

Martin Gerstel

Management

Yes, we can. Brett Reiss – Janney Montgomery Scott: Great. What’s the aggregate amount of large Pharma companies you are having these discussions on and is there any first mover advantage by any particular Pharma company to strike the first material deal with you?

Martin Gerstel

Management

We’ll, I think as we said we are talking with a number of companies and the fact that we stated that these are companies from North America, Europe and Asia I think will give you a feeling that there are a number of companies there. If it’s a reasonable number it would be misleading to actually state the number because that is the question as to where do you draw the line and then if you want the number of companies that we’ve discussed our products with, it’s a very big number, if you want the number that where the current discussions are at a certain stage, then of course it gets -- some of these companies are at earlier stages. And from the stand point of sort of a first mover advantage, I don’t think that – we are talking with major companies and this is an area of high, a very high interest for them but they look at this and then obviously in a very professional and careful way. You can imagine the number of product opportunities they see both internally and externally and – so at this stage, they are just going through their due diligence. Anat, you want to add more?

Anat Cohen-Dayag

Analyst

I think that with respect to your last comment about priority I would like to add that we are not conducting the discussions based on priority. This is more has to do with how much there is the fit, there’s an expertise that is associated with this type of per candidate and to make sure that we increase the probability of success of our molecules in the clinic. Either in clinical trials or later and all these parameters has to do with setting priorities. And also one other thing that we take into consideration is how much the partner will have an interest for us to participate in early stages of development and increase probability of success. Brett Reiss – Janney Montgomery Scott: Can I ask another one or you want me to get back in queue?

Martin Gerstel

Management

That’s okay. One more you got. Brett Reiss – Janney Montgomery Scott: Okay. This operative phase in your press release clear and positive feedback we are receiving from major pharmaceutical companies. Pretend I am your six year old grandson. Can you describe to your six year grandson what – can you be a little descriptive what are those conversations revolve around? What are they asking you? What are you saying to them?

Anat Cohen-Dayag

Analyst

I think that it will be a mistake for us to dive into the details of discussions that we are having but of course we are relating to their impression with respect to our discovery capabilities that have led to these discoveries of product candidates and to the potential value of the product candidates themselves but I think that we can’t get into the details of discussion.

Martin Gerstel

Management

One aspect of this that I have found interesting is that in earlier discussions with pharmaceutical companies before we had the pipeline and we are attempting to get them to work with us with respect to our capabilities. The questions always related to them trying to understand our – the way we did things, how do we do the predictive discovery. Even to the extent of some of them even wanting to have access to the certain of the algorithms that we utilize, which of course we would not share with them. What is totally different now is when they see these results, the question as to how do we do things goes out the window. The results speak for themselves, there’s absolutely no reason now for any pharmaceutical company to have to make a judgment as to whether or not our predictive biology works. The evidence is 100% clear, we’ve used -- in areas of high interest for them in a tiny fraction of the time and money that has been committed to this field by others. Orders of magnitude less by us than other people, we have made discoveries that they have not been able to make and not only that but have now taken those discoveries into the exact same disease animal models that they rely on in order to evaluate whether or not their product candidates are worthy of further development and are not referred to the incredible level of success we have had in these meetings. So I would say following up on whether or not that one, there is an enormous appreciation for the uniqueness and the accuracy and the power of what we’ve accomplished here in the case the infrastructure that now exists here and there is a very strong interest, and it varies company by company, indication by indication, molecule by molecule. So it’s in many different areas but there’s a significant amount of interest out there. Brett Reiss – Janney Montgomery Scott: Has any company…

Martin Gerstel

Management

We’ll, that’s your third. Brett Reiss – Janney Montgomery Scott: Okay. I’ll drop back.

Operator

Operator

(Operator instructions). Please stand by while we pool for more questions. The next question is from Klaus Von Stutterheim – Deutsche Bank. Please go ahead.

Klaus Von Stutterheim

Analyst

Can you talk about the expected burn rate for the next 12 to 24 months and possible sources of funding?

Deutsche Bank

Analyst

Can you talk about the expected burn rate for the next 12 to 24 months and possible sources of funding?

Martin Gerstel

Management

Well, as Dikla mentioned, we had capital available, available sources of capital that takes us we’ll into 2014 given our current burn rate. And our burn rate is very much under our control in view of the fact that if we were to increase it would be with doing more tests out of – not in the company but with providers and whatever. So we don’t see any immediate crisis in any way. Of course companies like ours should always have substantial cash on board.

Dikla Czaczkes Axselbrad

Management

I would add to that as you probably can imagine we are now in the process of budgeting for 2013 and this will of course be approved. The budget will of course be presented with the board and approved by them hopefully. And we’ll probably give specific guidelines at the end of the year but as of now we do not see dramatic change from this year level of expenses.

Klaus Von Stutterheim

Analyst

Many thanks.

Deutsche Bank

Analyst

Many thanks.

Operator

Operator

The next question is a follow up question from Brett Reiss, from Janney Montgomery Scott. Please go ahead. Brett Reiss – Janney Montgomery Scott: Hello again. Had the discussions with any particular Pharma company gotten to the point where they have specifically said to you what more they need from you before they would be willing to commit to material financial deal where there’s material consideration that would be extended to the company?

Martin Gerstel

Management

I don’t think we should get into this discussion but the only thing I would say is that the discussions really don’t kind of don’t go there in that direction. They do their due diligence, they request information, we provide it to them. So but I guess let me just drop it at that. We cannot – even if we wanted to, there’s not very little that we could tell you that would assist you to give you what you are looking for that is because we can’t. No one can really know when the first deal is going to be signed. There’s just no way – these are complicated agreements and the complications get involve in its intellectual property and licensing rights and all kinds of due diligence requirements, things that -- they are very complicated agreements. So they can take some fairly extensive time just to draft the arrangements. Brett Reiss – Janney Montgomery Scott: Okay. Thank you.

Operator

Operator

There are no further questions at this time. Before I ask Dr. Cohen-Dayag to go ahead into our closing statements, I would like to remind participants that a replay of this call is scheduled to begin in two hours for a period of 72 hours. In the U.S. please call 188-782-4291. In Israel, please call 03-925-5904. Internationally please call 972-3-925-5904. Dr. Cohen-Dayag, please go ahead with your concluding statement.

Anat Cohen-Dayag

Analyst

Yes, thank you. Before assuming the CEO position at Compugen in early 2010, I had been head of our R&D activities and therefore had a good appreciation of the capabilities and enormous potential that had been created by our exceptional team of scientists. However, the proof of this potential at that time was largely in the form of novel molecules demonstrative the discovery capabilities of the individual platforms but not necessarily molecules targeting clear un-mathematical needs with superior properties to those already known. These discoveries were critical in validating the predictive capabilities but not very useful when trying to convince others that Compugen’s discovery infrastructure could be focused to specific areas of interest and lead to popular candidates with potential superiority. Therefore, my first major decision as the CEO was to undertake our initial market directed discovery program utilizing all of our integrated capabilities not just in individual discovery platform in an area of high industry interest and direct them towards the discovery of superior targeted medicine. As we have discussed, we chose the very complex fields of Oncology and Immunology, and within these fields our first area was the B7/CD28 immune check point family of proteins. Since this protein family is of immense interest in the industry with applications in both of our fields of focus. Furthermore, new family members had proven extremely difficult to find using conventional experimental basic discovery effort. We are very pleased to be now sharing the exceptional results we have achieved in this first proper discovery efforts with leading companies in our industry. The response we are receiving is very satisfying not just with respect to the medical and commercial potential of our product candidate but with respect to validation of the power and uniqueness of the predictive discovery infrastructure that we have created and continued to enhance. With this in mind as we now approach the commercialization stage in the form of collaboration agreement for the first wave for our product candidate from our pipe end program, we want to particularly thank our long term shareholders who have supported us through this long but value creating journey. Thank you and we look forward to sharing with you further development in the near future.

Operator

Operator

Thank you. This concludes the Compugen Limited third quarter 2012 financial results conference call. Thank you for your participation. You may go ahead and disconnect.