Andrew Philip Witty
Management
Thank you very much, and thank you for joining us for this afternoon's call. I'm here with Simon Dingemans, who'll pick up on the detail of the quarter in just a few minutes. We'll make a few introductory comments. You will have seen from the quarter release that in the third quarter, turnover was down 3%, earnings per share up 5%, bringing year-to-date earnings per share to minus 2 at constant exchange rates. Clearly, the quarter helped by targeted expense reductions. We're on track for full year EPS to be broadly similar to last year at CER, excluding divestments. During the quarter, strong Emerging Markets, Japan and ViiV HIV growth, offset to some degree by the continued trend in the U.S. Just turning to the U.S. The trend we're seeing is driven by the impact on pricing of Advair and access limitations becoming more common in delaying product uptake in primary care. Pricing. The pricing effect has been a bit greater than we expected earlier in the year, driven by market changes and competitive dynamics. It does feel like a new reality in U.S. primary care, and as we look across other product launches and other product categories, Breo and Anoro launches benchmark well, but all launches appear to be, in primary care, much slower. Now obviously, this has had impact for us in 2014, but we've adjusted quickly to the situation, both in terms of how we're contracting and also in management of our SG&A line. We now have very good visibility for 2015, as we have signed the majority of contracts and won substantial access for Advair, Breo and Anoro, with the substantial majority of top plans already secured. In some cases, with exclusive positions for some of our products, i.e. with the beneficiary of class lockout contracts, whereas June 2014, we've been the victim of class lockout contracts. During 2015, we'd expect to see the price effect flow through from 2014. We expect a continued to decline of Advair as a result, but we also expect an acceleration of Breo and Anoro as access increases and heavy free trial offers begin to come to an end. We also expect to see Advair volumes increase as the product regains coverage on key formularies. Globally, we expect total Respiratory to return to growth in 2016 and remain confident in our long-term market leadership ambition. The Novartis transaction is the other major event of 2014 and is on track for completion in the first half of next year. I'll remind you that the deal will realize $16 billion of proceeds as we sell the Oncology business. I'll remind you also that 7 years ago, we essentially had almost 0 sales in Oncology. The whole business built from the pipeline that we've delivered during that period. The $16 billion will fund the full GBP 1 billion B-share scheme during 2015 for our shareholders. The deal will also fundamentally reshape the company as immediately, the largest sales base will be around 40% exposed to high annuity businesses of Vaccine and Consumer and will benefit from the higher terminal growth rates you'd expect from those 2 businesses. This provides new opportunities for sustainable sales and earnings flows. The deal will ensure market leadership and true global scale for both Vaccine and Consumer and will allow us for the first time to appropriately report on these businesses alongside the RX business. We're taking this moment to change the executive management structure of the group to ensure focus in senior leadership of the 3 commercial businesses going forward. With Moncef Slaoui moving to take overall leadership of our Vaccine business. Obviously, a highly accomplished vaccine expert and will work with our current management team there to integrate the Novartis business, a highly complex piece of work and the right person to lead it. Abbas Hussain, who's been running our International Pharmaceutical business will now take up a new role as Head of Global Pharmaceuticals and will take the U.S. into his portfolio working with Diedre. And Emma Walmsley, who joined us a few years ago from L'Oreal will lead the Consumer Healthcare joint venture. As a result of Moncef's focus, Patrick Vallance will become head of Pharma R&D. These changes put some of the industry's most experienced leaders in our enterprise leadership positions, and will be responsible for implementing the transaction in Vaccine and Consumer and delivering the portfolio transformation in Pharma. Turning to Pharma, specifically. After the unprecedented number of new drugs and vaccines approved over the last few years, we have 3 points of focus on opportunity going forward. Firstly, the continued rollout and launch of the Respiratory HIV, diabetes and until the close of the transaction on oncology new medicines. In fact, in 2015 alone, we expect around 250 discrete pipeline product launches around the world, so each camp being one new pipeline product in one new market. Second, we intend to bring forward the next wave of products with around 40 new molecular entities in late development and a very exciting portfolio now emerging from our DPUs, with mostly first-in-class potential therapies in areas such as cancer, heart failure, Respiratory, inflammatory and autoimmune disease. Third, to focus and scale our RX operations for the change in pricing dynamics we see and for the movement of oncology to Novartis, and to ensure that research and development has the right level of flexible resource to further deliver the next waves of innovation. We're announcing today, therefore, a new restructuring program in addition to the announced Novartis-related program, which will reshape our Pharma business and release GBP 1 billion of annual cost savings, and ensure we have moved resources to our current and next waves of new products. In line with my long-term belief in passing value into the hands of shareholders, we have, over the last 6 years, repeatedly identified and created opportunities to build and crystallize value. Through dividends, special dividends, share buybacks or the Plan B scheme has sought to return this value to our shareholders and are focused on organic drivers of growth rather than engage in high-premium acquisitions. Since I became CEO, we have returned GBP 33 billion to shareholders through dividends and share buybacks. Clearly, our ongoing established product portfolio process, which we aim to bring to conclusion around the turn of the year and the oncology value creation are clear and current examples of this approach. Five years ago, I created a JV in our HIV therapy area, at a time when GSK was suffering substantial competitive and generic pressure and risk. ViiV has been an extraordinary success story and has now established -- establishing itself as an innovative and fast-growing specialty business. Our new dolutegravir-based medicines have already sold over GBP 170 million this year, with significant further pipeline opportunities already advancing. We have a very high belief in ViiV's prospects. In line with our commitment to identifying ways to realize shareholder value, we have announced today that we are beginning the process to explore possible IPO of a minority stake in this business. On dividend, for the quarter, we have maintained a dividend of 19p, and we expect the full year 2014 dividend to grow 3% to 80p. We've also provided guidance today for shareholders out for 2015. We expect to maintain the dividend of the same level as 2014. This will provide us with flexibility as we restructure and integrate the Novartis businesses next year. Despite the challenges that the U.S. Respiratory market has brought during 2014, the Novartis transaction, the reshape of the Pharma business and the substantial R&D progress, marked major steps forward in our long-term strategy. The potential to IPO minority stake in ViiV further signals, alongside our oncology transaction, a patient but enduring commitment to explore avenues to create shareholder value while delivering our global mission to improve lives around the world. To the point of our mission, I would be remiss not to acknowledge the many GSK employees who are working tirelessly on our candidate Ebola vaccine. Given the apparent health emergency, we are leaving no stone unturned in this project. And if all goes well, I fully expect GSK to be the first company in a position to make a vaccine available to health agencies and governments hopefully, toward the end of 2014. This, in the same year, that GSK filed for approval for the world's first vaccine against malaria. With that, I'll close my comments and ask Simon to give you a more detailed review of the quarter.