David Redfern - GlaxoSmithKline Plc
Analyst
Yeah. So, Graham, on Tivicay and Triumeq, I think the first point actually, on a global basis, prescription trends continue to be very solid. In the U.S., we measure what we call core and SDR market share, and for dolutegravir overall, we're now above 26%. We started the year a bit below 23%. NBRx is just over 30%, holding very steady. And dolutegravir remains the leading integrase prescribed in the U.S., and indeed throughout the world. It is true, as you say, there is a mix effect, and there's growing demand and increasing growth rate of Tivicay compared to Triumeq. We think about 40% to 45% of Tivicay now is prescribed with Descovy, and that's obviously a popular regime. I think – I mean, from the market research we've done, of course the competitive intensity will increase next year as the competitors launch, and I'm sure at the margin there will be some doctors that may switch. But, the research we get back is, the vast majority are prescribing Tivicay because they want to prescribe the best third agent, which they view to be dolutegravir. And for patients that are well tolerated and doing well on Tivicay, we think there's every reason why they won't be switched and they can remain on their current regimes. We've seen now quite a lot of the clinical data on bictegravir. Clearly the headline is, it's not inferior. If anything, efficacy just a touch below some of the efficacy rates we've seen in the dolutegravir studies. So, I think the answer is, the competitive intensity will go up, but we feel we've got a very strong database, and very good reasons why Tivicay should continue to be prescribed. In terms of the payers, I mean, I'm not going to get into lots of detail around the tactics of that. It's a very different marketplace in a specialty area like HIV to Respiratory. We have very high, if not virtually total coverage, and I don't see any change in the dynamics with the payers in our HIV business going through 2018 and this year. The exact tactics and so forth versus Gilead, I think we'll keep confidential.