Welcome to the Q1 2017 Illumina Incorporated Earnings Conference Call. My name is Adrienne, and I'll be your operator for today's call. At this time, all participants are in a listen-only mode. Later, we'll conduct a question-and-answer session. Please note this conference is being recorded. I'll now turn the call over to Rebecca Chambers. Rebecca Chambers, you may begin.

Thanks, Adrienne. Good afternoon, everyone, and welcome to our earnings call for the first quarter of fiscal year 2017. During the call today, we will review the financial results released after the close of the market and offer commentary on our commercial activity, after which we will host a question-and-answer session. If you have not had a chance to review the earnings release and earnings presentation, both can be found in the Investor Relations section of our website at illumina.com. Participating for Illumina today will be Francis deSouza, President and Chief Executive Officer; Marc Stapley, Executive Vice President and Chief Administrative Officer; and Sam Samad, Chief Financial Officer. Francis will provide a brief update on the state of our business and Sam will review our financial results. This call is being recorded and the audio portion will be archived in the Investor section of our website. It is our intent that all forward-looking statements regarding our expected financial results and commercial activity made during today's call will be protected under the Private Securities Litigation Reform Act of 1995. Forward-looking statements are subject to risks and uncertainties. Actual events or results may differ materially from those projected or discussed. All forward-looking statements are based upon current available information and Illumina assumes no obligation to update these statements. To better understand the risks and uncertainties that could cause actual results to differ, we refer you to the documents that Illumina files with the Securities and Exchange Commission, including Illumina's most recent Forms 10-Q and 10-K. With that, I will now turn the call over to Francis.

Thank you, Rebecca, and good afternoon, everyone. Q1 was a strong start to the year. The NovaSeq launch surpassed our expectations with more than 135 orders in Q1. Revenue grew 5% year-over-year to $598 million with consumables and services growth more than offsetting the expected decline in sequencing instruments related to the NovaSeq introduction. We were very pleased with both the level of customer interest in the new platform, as well as the positive feedback we received on NovaSeq's attributes. NovaSeq was designed to be the most powerful sequencer ever made. Its price points and throughput enabled customers to increase experimental scale and complexity from panels to exomes and from exomes to genomes, as well as increase sequencing depth. Like the GA, HiSeq and HiSeq X, we are confident that NovaSeq will also demonstrate the elasticity of the genomics market and redefine its trajectory. We were pleasantly surprised by the level of NovaSeq interest from our HiSeq X installed base – as more than a third of HiSeq X customers place NovaSeq orders; many of which were multi-unit deals. We also saw the start of the HiSeq replacement cycle, as the majority of our customers that ordered NovaSeqs were legacy HiSeq customers looking to refresh their fleets and run at the more economic price per gigabase. With an active HiSeq user base of approximately 800 customers, the replacement of older generation instruments by NovaSeq is just beginning. Since launch, we have heard from customers a desire to address each lane of the flow cell independently to more easily allow them to load different library pools, applications and samples. Yesterday, we unveiled a new development program that will bring to market an accessory device and associated consumables to provide this functionality. Compatible with all NovaSeq flow cells, this updated workflow will…

Thanks, Francis. As Francis mentioned, Q1 revenue grew 5% year-over-year to $598 million, slightly exceeding our quarterly guidance. Geographically, revenue in the Americas grew 4%, while we saw a decline of 2% in Europe. Asia Pacific grew revenue 15% versus the prior year. Continued weakness in Japan's genomics funding was more than offset by China shipments, which grew more than 35% due to clinical and high throughput instrument demand. Given the transition in our high throughput portfolio, instrument revenue declined 15% year-over-year to $100 million, in line with our expectations. First quarter consumable revenue represented 65% of total revenue or $387 million, an increase of 7% compared to the first quarter of 2016. Sequencing consumable revenue also grew 7% year-over-year to approximately $320 million as a result of growth in our installed base. Utilization trends across the benchtop portfolio were steady, as pull-through came in within each instruments' respective guidance range. HiSeq and HiSeq X consumable revenue was slightly below our forecast, as customers ramped down their reagent orders at a rate that slightly exceeded our expectations; instead, using inventory on hand given the upcoming integration of NovaSeq into their operations. We believe our customers continue to sequence in Q1 at typical rates, despite the lower reagent revenue, which is an indicator of the expected reagent rebalancing required with the launch of NovaSeq. This transition impact is expected to continue in Q2 before improving in the second half. We removed close to 20 HiSeq instruments from our installed base during the quarter, a figure which is expected to increase as customers begin to ramp up production on NovaSeq. Services and other revenue grew approximately 20% versus Q1 2016 to $107 million. This improvement was driven by strength in genotyping services due to consumer demand and sequencing instrument maintenance contracts. Turning…

Thank you. We'll now begin the question-and-answer session. And our first question comes from Tycho Peterson from JPMorgan. Please go ahead.

Hey, thanks. First question on NovaSeq. Congrats on the orders. I guess as we think about what the funnel looks like – I know you said the majority were legacy HiSeq customers – can you talk a little bit about any mix dynamics there in terms of low throughput versus high throughput labs, 2500 versus older customers? And anything, I guess, we should be thinking about in terms of the pacing of GRAIL orders throughout the course of the year?

Sure. Hey, Tycho. So as we look at where the orders came in in Q1, I'd say the majority were HiSeq legacy customers as we pointed out. About 40% came from customers who are just HiSeq X customers, so the large genome centers, for example, and then about 10% were new to sequencing. And so, we were really encouraged to see sort of the broad mix of customers, validating the thesis that there is an upgrade cycle in progress here that's starting from HiSeq, but that the NovaSeq platform is also attractive to HiSeq X customers, especially as four comes out later in the year. We're also starting to have conversations with people who are entering the high throughput space with the promise of what NovaSeq can do around certain projects. So, early indications but it was good to see customers from a number of segments sign up to NovaSeq. In terms of GRAIL...

Go ahead.

In terms of GRAIL, we talked about the fact that over the course of the year, we expect less than 1% of our company revenue to come from GRAIL, and we still expect that.

And then can you help us on the 2Q guide? You're coming in $0.20 lower than the Street. Is that all higher OpEx? And can you maybe talk about what those incremental investments largely are?

Yeah. Hi, Tycho. This is Sam. So, I think some of the dynamics that we saw in Q1, specifically with regards to gross margin, we expect to see again in Q2. As we ramp up the production of NovaSeq, as we ramp up the manufacturing, as we also see some of the transition in consumables with the customers whether it's validating their workflows, depleting inventories, we expect to see similar gross margin profile in Q2 – actually slightly lower in Q2. So I think that's a key driver. There is some operating expense growth as well that drives the EPS as well. So, I think those are the key drivers in terms of the sequential Q1 to Q2 EPS.

And not nearly as meaningful, but just Helix will continue to ramp sequentially as well. Just more of a small impact, though.

Okay. If I could squeeze one more in because it's an important question we're getting a lot. It's just on the cross-contamination, barcoding issues, Francis. Can you maybe just comment on that and I'll hop off? Thanks.

Sure, Tycho. So, we've been working with a couple of customers who've experienced elevated levels of this index swapping on the HiSeq 4000. We don't expect it to have an impact on the NovaSeq demand trajectory going forward. As background, we have seen low levels of index swapping in the 0.1% to 2% range. And that's been sort of a part of the noise, if you like, in (19:44) now ever since the GA at a very low level. It has really no meaningful impact on sequencing results for the vast majority of applications, and there are a number of best practices, including using washers to remove free adapters from libraries, using unique dual indexes that further reduce even this low level of index swapping. We have been engaged with a couple of customers in the last quarter that have seen elevated levels of index swapping on the HiSeq 4000. We've been working with them to understand the specifics of their situation and share best practices that will help mitigate the issues that they're seeing. As we think about NovaSeq, I said we don't expect to see an issue, and the offering we have coming out later this year that will help customers address individual lanes will help mitigate this issue even further because it will lower the level of multiplexing that you need to do on NovaSeq.

And another question...

Sorry.

Our next question comes from Doug Schenkel from Cowen & Company. Please go ahead. Doug Schenkel - Cowen & Co. LLC: Okay. Good afternoon and thank you for taking the questions. Recognizing it's still early, is NovaSeq driving any increased demand from biopharmaceutical customers?

Hey, Doug. At this stage, it's too early to call sort of an industry trend like that, so it's certainly driven a lot of conversations, but again, too early probably to call out a specific trend like that. Doug Schenkel - Cowen & Co. LLC: Okay. (21:24) Doug Schenkel - Cowen & Co. LLC: Regarding the develop – oh, go ahead. I'm sorry, Rebecca.

No problem. I was just going to say outside of Regeneron that we highlighted is one of the initial customers at JPMorgan. Doug Schenkel - Cowen & Co. LLC: Okay. Thank you for that. Regarding the development of the workflow to allow for multichannel loading of NovaSeq flow cells, is this largely to accommodate some of the smaller core labs that were concerned about number of samples required to make the economics work on the NovaSeq? And I guess on your website, you indicated you decided to make this new workflow available based on customer feedback, factor again this feedback, how much demand do you think this change opens up in terms of market opportunity?

Sure. So, this new offering does help address a number of things, including some of things you talked about. What it does is it allows customers to run experiments with samples that have lower DNA inputs. It allows them to run different applications across the different flow cells. So, it gives you a number of things that customers have wanted that they've given us feedback on since we launched the NovaSeq. In general, these are sort of incremental improvements to the NovaSeq platform. And so, we shouldn't expect a dramatic change in the demand trajectory associated with NovaSeq because of these improvements. They are good but they're not going to change fundamentally the demand trajectory. And also, this comes out in Q4. And so, it really shouldn't have much impact on 2017 at all. Doug Schenkel - Cowen & Co. LLC: Okay. Thanks for that. One last quick one and then I'll get back in the queue. Given the stage where you are in the product rollout and the manufacturing ramp, I know in your prepared remarks you talked again about the expected manufacturing constraints progressing through the supply chain, is it fair to assume that was a full quarter of production that you could at least double the number of NovaSeq placements in the second quarter? Thank you.

So, I'll start by saying I touched on this in the prepared remarks, but we're very happy with where we are at the end of Q1. Obviously, an instrument like NovaSeq is a brand-new architecture from the ground up. And so it was a very big task to scale up the manufacturing process on something like a NovaSeq. And so, as we close out the quarter, we shipped just over 25 instruments and not only are we happy with the number, but we are also very happy with the quality of the instruments and the quality of the data that our customers are seeing. We expect to continue to ramp, as we said, over Q2 and Q3. And over Q3 we expect to be at the stage where we are – we expect to exit Q3 at the stage where we're meeting the incoming order demand. I think that we haven't given specific guidance in terms of the manufacturing for Q2, but something along the lines of what you talked about seems reasonable. Doug Schenkel - Cowen & Co. LLC: Okay. Thanks again.

The next question comes from Ross Muken from Evercore ISI. Please go ahead.

Hey, guys. It's Luke (24:44) in for Ross today.

Hey, Luke (24:47).

I guess, as you look at the evolution of the sequencing market and as it's gone all the way back to the GA, and now we're pushing on the edge of clinical sequencing, how has the feedback from customers kind of shaped your medium-term opportunity?

As you point out, we've seen these step changes in the market before as we put out the GA and the HiSeq and the HiSeq X. And so we come in to this with that experience. And so far I would say that NovaSeq has played well to our expectations, that we expected NovaSeq to drive an upgrade cycle in our high throughput customer base starting that with the HiSeq customers and then to the HiSeq X customers and that starting to play out as we talked about in the quarter, we do think now that this will drive – with the data we have, this will drive that upgrade cycle in our legacy customers. We've also talked about the fact that we expect NovaSeq with its power and its price points to drive the elasticity of the market. And it is early, but there are indications we're getting from our customers in terms of new projects that have been announced like the Regeneron-Glaxo project for the Biobank in the UK. Those kinds of projects as well as ultra-deep sequencing project in the oncology market as well as liquid biopsy sequencing. So, three months, it's early data. But the early data is very consistent with the hypothesis we had when we embarked on the development cycle for NovaSeq.

Great. Thanks.

And the next question comes from Derik de Bruin from Bank of America. Please go ahead.

Hi. Good afternoon.

Hi, Derik.

So, you mentioned 20 HiSeqs came out of the mix during the quarter in your genetics accelerate (26:48). Do have any sort of estimates for where the HiSeq number will end up be in VRM (26:54)? I'm trying to get to the swap ratio and sort of what's the indication from customers that have bought so far or so far of what – how many HiSeqs are going to pull out for the Novas?

Derik, we don't provide that number. And so, I guess, mostly what we can do to help you is sort of give you the qualitative results that we've talked about that we are seeing an earlier then maybe slightly earlier than expected conversation with the HiSeq X customers in terms of looking at NovaSeq. We certainly expect as S4 comes out, that we will see HiSeq X customers moving or re-platforming to NovaSeq. At this point, I don't have any data to give you – I can share with you around ratios.

And, Derik, part of the reason for that is, effectively, some customers are just testing out NovaSeq, so they aren't necessarily thinking about the ratio for the entirety of their fleet. Other customers are further down that path. And so the variance between customers is quite wide. Additionally, for us to take something out of the installed base, it needs to really not be used, right? And so, that's not something that really we can forecast at this point in time, because many customers do keep these boxes installed until they're not being used for quarters upon quarters. And so, that's more of a retroactive look and not necessarily something that we can forecast.

Got it. Right. And then, a quick follow-up on that. You said the consumable pull-down was a little bit more than you thought in terms of slower and – attributing that to more inventory reduction rather than delays in terms of the sequencing market, I agree with you, but I was just wondering if you did any – found any evidence at all that certainly the funding uncertainty in the market is having any issues?

I've not heard from anywhere that the funding uncertainty is what's driving the consumable slowdown. What we do know is that we initiated conversations with our high throughput customers and that has caused our customers to do a number of things. One, they are pausing, so they can talk to us about NovaSeq. They are drawing down existing inventory with the understanding that they are likely just sort of re-platforming the future. They're also not doing any large future buys for the same reason. And then initially, there will be the smaller purchases as they validate the workflows associated with the NovaSeq. And so, those are expected steps. And so, that's what's driving the slowdown that we saw in the consumables.

Great. Thank you.

Having said that, I'll just point out that Q1 is normally a strong order quarter for consumables, sequencing consumables in general. And we did see some backlog build there as well from our customers. So, those who aren't slowing down at least are still placing orders and expecting those to be shipped throughout the year.

Thank you.

And the next question comes from Dan Arias from Citigroup. Please go ahead.

Yeah. Hi guys. Thank you. Francis, can you just talk about the back half of the year? Any assumptions around the HiSeq X system pull-through once the S4 configuration is out there and presumably folks start doing holds more (30:14) on the Nova? Are you still thinking you can exit the year with the HiSeq X still in the $625,000 to $725,000 range?

So, we are not expecting those pull-through ranges to sort of carry forward as we go through this transition period. And so, I talked a little bit about the dynamics that are playing out and the high throughput market in terms of people looking to re-platform to NovaSeq and that is affecting the kinds of orders that they will be placing and the work that they'll be doing as they transition on to the NovaSeq platform. We are also expecting very little in terms of new X placements, obviously, as we look at Q2 going forward. And so, that will have some impact in the back half of the year overall as well.

And, Dan, we said on the Q4 call that we had suspended that range. And so, this isn't necessarily a change in messaging. It's effectively just the continuation of that messaging where we don't necessarily have a HiSeq or HiSeq X guidance range at this point in time because this transition is dynamic.

Yeah. And so, what you can expect to see is that this is going to be the transition year. And then, as we go through sort of a four-quarter period on NovaSeq, we'll be in a better position to start to talk to you about what you can expect on NovaSeq.

Okay. Thanks. And maybe just following up on your comments, Francis, on HiSeq versus HiSeq X customers in your order book, can you just sort of further that thought by talking about how many of the 85 or so orders beyond the 49 that you announced in January came from conversion of the HiSeq X backlog? I think there were 35 or 40 in the backlog as of 4Q. Just curious how many of those traded up.

We haven't done the breakdown on the post-49... (32:03)

I guess, 49 to the greater than 135 (32:05). I think the overall number is generally representative. I'd say, so I don't know – I haven't done the breakdown for the post, but I don't expect this incremental insight to come from that breakdown.

Okay. Thanks very much.

And the next question comes from Amanda Murphy from William Blair. Please go ahead. Amanda Louise Murphy - William Blair & Co. LLC: Hi. Thanks. I just had a couple of follow-ups to some of the questions that have been asked. So, I guess first on the replacement cycle more broadly, so you've talked to some of the demand that might have been a bit surprising for the legacy platforms outside of the HiSeq X. So, I'm just curious, I guess, does that demand change your view ultimately on what the magnitude of the replacement cycle could look like for the NovaSeq or the timing? And then, just if you have any updates on your thoughts around supporting or I guess offering the legacy platforms? I think you've made comments about HiSeq 2500, but some of the other HiSeqs?

Sure. I'll start by saying that we still deeply believe that NovaSeq will drive an upgrade cycle off our HiSeq customer base and over time our HiSeq X customer base. And so, we talked about the fact that we have 800 HiSeq customers. And we have north of 30 HiSeq X customers. We deeply believe that, and everything that's happened in Q1 in my mind sort of reaffirms that thesis for us. What we saw in Q1 was we saw slightly stronger than expected demand, we said, for HiSeq X and for HiSeq, and what was playing out there, where there are customers that are in the midst of running large whole genome projects, and they needed more capacity. And what they didn't want to do was switch platforms in the middle of a project. And so, they added capacity and they added Xs. We also saw some customers in China that continue to buy Xs because in that region it's a very competitive platform. And until we get to the S4, it's going to continue to be a very competitive platform. And then we had some clinical customers that have their validated workflows that are sticking with the platform that they are using. We think these are transition effects. I think they drop off very quickly even in Q2. And so, it doesn't really change our thesis around the upgrade cycle. Amanda Louise Murphy - William Blair & Co. LLC: Okay. That makes sense... (34:33)

...position on what our portfolio plan around the instruments we're looking to retire, that doesn't change. Amanda Louise Murphy - William Blair & Co. LLC: Okay. And I just had one other follow-up to Tycho's question on margin. So, just thinking about when you have the NovaSeq sort of up and running. Can you give us some, at least, qualitative commentary on the right way to think about the margin profile on the NovaSeq when you – from an instrumentation consumable perspective, particularly given that you're obviously launching higher performance cells and single loading cells going forward? Just on a sort of more sustainable basis.

Sure, Amanda. This is Sam. So, I think the way to look at NovaSeq margin profile from an instrument standpoint, I think it's slightly lower margin than our HiSeq platform, and I think as we go forward in the year and as manufacturing ramps up, the margin profile on the instrument will improve, but it will still be slightly below the HiSeq X instrument and the HiSeq profile. So, there will definitely be an improvement in the instrument margin as we go through the year, but it will still be below the HiSeq platform, higher than the benchtop platform though. From a consumable standpoint, I think the important part is that as we ramp up consumables in the second half of the year, we also expect to see a margin profile on the consumables that's on par with our high throughput consumables. Amanda Louise Murphy - William Blair & Co. LLC: Okay. Thanks very much.

And the next question comes from Jack Meehan from Barclays. Please go ahead.

Hi. Thanks. Good afternoon. I also wanted to follow up on one of Tycho's questions. You mentioned 10% of NovaSeq customers are new to sequencing. Is that what you thought the uptake would be like compared to previous new product launches and any other data points around new customer interest would be great?

Yeah. I mean that was a good number. It wasn't a hugely surprising number. Given the dynamics that we are seeing, we did expect some new customers to be created in the high throughput segment. Some of them are regionally oriented, so we're seeing new customers, for example, emerge in China. Some of them driven by the opportunity created by the Chinese Precision Medicine Initiative. So, the number wasn't really that surprising. And we expect to see some of that going forward. Obviously, most of the new-to-sequencing customers typically show up at the lower end of our portfolio, so 60% of the MiniSeq, MiSeq level of our customers coming in there are new-to-sequencing customers. But at the top end, 10% is not too surprising.

Got it. And then just as a follow-up. I wanted to ask about the service revenue strength in the quarter. It looks like it was coming through the microarray line. Just any color there would be great, or broader trends around service revenue.

Sure, Jack. Yeah, absolutely, it was coming in from the microarray line, and it's driven by the real strength we're seeing in the consumer market. And so, it's related to the services that we offer to the consumer market, which now for many quarters has been a strong segment for us.

Thank you.

And the next question comes from Bill Quirk from Piper Jaffray. Please go ahead. Alexander D. Nowak - Piper Jaffray & Co.: Great. Good afternoon everyone. This is Alex Nowak on for Bill today. So, the 135 orders surpassed your expectations but you also reiterated top-line guidance. So I'm just wondering if you could reconcile the two.

Yeah. The 135 orders was slightly better than we were expecting for Q1, but it's still very early in the year. We still have – the majority of the work to do for the year is still in front of us. This is still a back-end loaded year for us. And so, while we are happy with the way Q1 played out, we feel it's too early to change anything for the whole year. Alexander D. Nowak - Piper Jaffray & Co.: Okay. Thank you. And then the second question for me. What gives you confidence that there's enough sequencing demand that NovaSeq's consumable sales pull-through for instrument will be about the same if not better than HiSeq?

There are a few things. One is our experience now in this market across the introduction of multiple high throughput platforms has given us a track record now of seeing what happens with our customers that as we give customers high-throughput capacity, they are able to embark on more ambitious sequencing-intensive projects. And so, in previous platforms, customers were able to go from panels to exomes, from exomes to genomes with the HiSeq X. And what we're hearing from customers now is that more customers want to go from exomes to genomes. So, not just the HiSeq X customers, but now our HiSeq customers want to do that. And the HiSeq 4000 is good, but the NovaSeq really enables that. In addition, they're giving us examples of projects in areas like single cell or wanting to do much, much deeper sequencing for tumor normals or liquid biopsies or other applications where they're effectively looking for the uncommon needle in a haystack type of events. And so we're getting feedback from our customers around the projects that they want to embark on, which is consistent with the experience we had in this market before. And now, as we come out of Q1, it's clear that customers are buying a high throughput platform because they intended to use the capabilities that come from a high throughput platform. So, as they purchase, they have plans around which one they want to utilize the platform for and they have expectations that it will be a reasonably utilized platform, too. And so, now we have a few months of data now coming to us with customers reacting to a specific platform. And that's very consistent with our thesis (40:42). Alexander D. Nowak - Piper Jaffray & Co.: Okay. Great. Thank you.

And our next question comes from Isaac Ro from Goldman Sachs. Please go ahead. Isaac Ro - Goldman Sachs & Co.: Hi, guys. Thank you. Francis, I had a question for you on the consumer market. I think the FDA recently took a more dovish stance with regards to consumer testing for things like risk assessment and so just wondering if – just given that that was a relatively new development, if there's anything baked into your guidance this year with regards to an acceleration in those types of markets?

Yeah. That was a really good step forward, we think, for the consumer market. We are really happy about the impact it's going to have definitely and immediately on 23andMe. But we think it's a very good sign for the entire consumer market. So, Ancestry, Helix and everybody else, and that obviously is good for us, too. Now, we have known that 23andMe has been working on this for a while. And so, while it was news obviously when it happened, it's not entirely unexpected from our perspective. And so, it's consistent with our view of how the consumer market is likely to play out over the course of this year. Isaac Ro - Goldman Sachs & Co.: Got it. And then maybe just a follow-up. I think all the questions around NovaSeq were pretty well covered. So, I want to maybe focus on the other parts of the portfolio, on the instrument side, specifically, Firefly. I think you guys gave a little bit of an update in January regarding performance specs and timeline for end of year. Just wondering if that's still on track and any evolved thoughts on what that product line ultimately means for your expansion of the opportunity?

Yeah. The team is making very good progress on Firefly even since the update we gave in January. As we talked about in January, the intent is to bring out the sequencing box end of this year, beginning of next year and then bring out the library print box about a year later, and the team is on track to do that. This is one of the fortunate situations where we've announced the product well before bringing it into the market. And one of the reasons to do that was to allow us to engage with prospective customers. And the team has been doing that. And so, it's starting to get a good sense for the customer segments that it will be applicable for and what's particularly exciting is they're identifying customer segments that may be new to sequencing that are attracted to Firefly. And so, good progress, on track with the timelines that we talked about in January. Isaac Ro - Goldman Sachs & Co.: Got it. Thanks a bunch.

Thank you, Isaac.

And our next question comes from Steve Beuchaw from Morgan Stanley. Please go ahead.

Hi, Steve. Steve C. Beuchaw - Morgan Stanley & Co. LLC: Close enough. Good afternoon and thanks for taking the questions. So, first question is on consumables, in sequencing consumables. Sam, could you put any more granularity around what you saw in the first quarter and the impact of some of these dynamics around Nova and the way customers are thinking about the transition? I mean, given that you have – I would imagine a pretty good handle on who the customers are, do you have any idea of what sequencing consumables growth might have looked like on an apples-to-apples basis in a scenario where we didn't have the Nova transition?

Yeah. It's hard to give you kind of the apples-to-apples comparison that you're asking for, but let me give you a little bit of color, at least, in terms of what we saw in Q1 and expectations going forward. I think what we saw is basically almost what we expected which is, as Francis mentioned before, customers essentially validating their workflows, pausing, depleting some of their inventories. And we think that played into the lower sequencing consumable volumes that we saw in the quarter. And we think this is expected, given the rebalancing to a new platform, which is NovaSeq. And as we look forward, specifically to the second half, I think the expectation is that we would see a ramp-up in consumables. Now, as we said, going into Q1, that consumable growth is going to essentially decelerate given some of that time that customers will need to ramp up on their consumable purchases of NovaSeq. But essentially it's playing out as we pretty much expected, maybe slightly lower consumables on the HiSeq, HiSeq X compared to what we had expected. But as we look forward, we think that that's – our expectations are that we will see consumables ramp up with the NovaSeq uptick.

In the back half of the year.

In the back half.

And one thing to add to that, Steve, is there is absolutely nothing that we've heard from our customers that would lead us to believe that there's anything going on with regard to sequencing consumables beyond this natural transition. We have seen very, very large customers work down their inventories on hand, which led to the sequential decline in the high throughput component of the portfolio. So I think that is absolutely on par with our expectations. To Sam's point, maybe a little bit quicker than we had expected, but that is aligned with HiSeq X customers exceeding our expectations with NovaSeq. So, it's all one and the same in terms of the drivers. And on an apples-to-apples basis, ex the NovaSeq transition, we would expect nothing beyond the traditional formula of what sequencing consumables would do in any given quarter. Steve C. Beuchaw - Morgan Stanley & Co. LLC: Okay. I appreciate all the color there. And just one follow-up here and that relates to the operating expense where there has been some commentary in the prepared remarks on adding new feet on the street, if you will, new folks throughout the organization. I wonder if you could spend a minute just talking about where these people are headed. Then maybe if you could compare head count growth that you're thinking about for the company in 2017 relative to the last couple of years, just as we think about the modeling, that would be a big help. Thanks again.

Yeah. So, one of the areas we are going to be adding feet on the street is around focusing on the low end part of our portfolio, the benchtop instruments. So, we're looking to add an inside sales team, expand the inside sales team that focuses on that part of the portfolio, additional lead generation capability to drive leads into that part of the portfolio. You, as a customer, would have already seen the investments we've made in e-commerce. So, that's come online in the past few months, and we're going to continue to invest there because we think there's a real opportunity to improve the customer experience, as well as improve the velocity at which we do deals, and our cost to serve by moving the – part of the consumables part of our business as well as the low end portfolio through e-commerce. And so, those are some of the areas that you can expect to see us expand our capacity.

I would just add geographically in China as well as a major investment for us this year.

And our next question comes from Puneet Souda from Leerink Partners. Please go ahead.

Hi. Thank you for taking my question. Just one briefly – I just wanted to understand a little bit, I think it's been covered – parts of it had been covered before. But as the installs that are already happened, some of them have gone through the validation. If you could talk about and maybe give color on how labs are designing experiments? I'm sure there are some labs that are transitioning from validation to designing their own experiments on this. Are they simply waiting for S4, or are they in the meantime using the S2 flow cell to try to do some of these experiments? And does that – and taking on some of the production samples on to S2 and does that change your view at all on timing of S4 and maybe potentially moving that up?

So, I'd say that if you think about the makeup of the people who bought NovaSeq, I said, the majority of them were legacy HiSeq customers. And so, for them the move to S2 is a beneficial move on its own. And so, they're certainly not waiting for S4 and nor do they need to. And so, we expect the people who bought NovaSeq will start to sequence on S2 and very few (49:26) will be waiting for S4 before they start sequencing. Obviously, if you are a HiSeq X customer, you're designing very large experiments. The S4 is a really exciting flow cell for you. And it was actually that feedback we got from customers when we launched the NovaSeq that caused us to pull the S4 in from Q4 to Q3. And so, that's our plan of record, and that's the plan that we're going to stick to, but it was very much driven by the higher-than-expected interest we got in S4 from HiSeq X customers, certainly.

Okay, got that. And then just a one quick follow-up. Could you update us on the manufacturing ramp? I mean, there is – obviously, the HiSeqs are getting essentially reduced in some of the facilities, the San Diego, the Bay Area, the Singapore and Cambridge facility and the Wisconsin facility that you have. So, just trying to understand how are you ramping up NovaSeq and re-tooling some of those facilities to ramp up on both flow cells and the instruments.

Yeah. (50:38) NovaSeq is a completely brand-new architecture, and every major component is a brand-new component in NovaSeq. And so, it has been a really big effort on behalf of our operations team to ramp up our manufacturing capability on NovaSeq and transition that product from product development into our operations team. And I am incredibly proud of the terrific work that team has done in getting to where we are and allowing us to be slightly ahead of where we expected to be, as we got out of Q1. The way we think about our facilities broadly is a lot of our new introduction work happening here in the U.S. close to the development centers, and that's consistent with how we're thinking about ramping up NovaSeq. And that's sort of how we're thinking about it.

Okay, great. Thanks for taking my questions.

Thank you.

And our next question comes from Dan Leonard from Deutsche Bank. Please go ahead.

Thank you. Just wanted to clarify. Well, two questions. The first one, clarification on gross margin. Sam, I think you mentioned that the promotions and the high throughput sequencing market were part of the depression on gross margin in the quarter. Can you clarify what you're doing in the promotional space and the high throughput market and why that would continue in Q2?

Well, as we ramp up NovaSeq and for some of the customers that have ordered HiSeq in the past, we've said that we were going to have a promotion where we would match some of the prices. So we have – essentially that's had a negative impact on ASP on some of our high throughput instruments. So, that's primarily the reason...

In the first quarter, but that's just not expected to continue into the second quarter, Dan. The second quarter impact is more along the line of the ramping NovaSeq – effectively mix...

Yeah. So...

...in the sequencing instrument line.

Right. So that's the second part, which is as we move forward, it's really a question of NovaSeq ramping up in terms of production. And until the volumes catch up in Q3 and Q4, we're going to continue to see some negative impact on gross margin in Q2 because of that.

Okay. That's what I wanted to clarify. Thank you. And then my follow-up question. Can you offer us an update on what percentage of your revenue is China? And you're going to be rolling up again some pretty tough comps in the second half from China, and whether you expect the growth rate to continue at the levels you've been seeing?

Yeah. We remain bullish on the Chinese market opportunity. Roughly, you should think about it already around 10% of our business. And the secular drivers of the market there continue to be positive. So, we're seeing growth in the clinical markets associated with both NIPT and oncology, and that played out last year. We expect – that trend is continuing to play out this year. We're also seeing demand driven by the government's Precision Medicine Initiative. So, money has started flowing. Projects are being funded, and that is causing customers to purchase our instruments, that's causing in some cases new customers to be created. And all that is going to continue to play out, certainly over the course of this year, but likely for a few years. In this quarter, Annoroad just got clearance from the CFDA around its assay, and that will continue to give it momentum in the market. And so, it's a market we are excited about.

And just one thing to highlight with regard to our outperformance in the region last year, obviously, we'll have a challenging comp as we go throughout the course of this year and the benefit of HiSeq X instrument sales in particular that we saw last year. So, just to take that into account, I completely echo Francis' statements with that caveat.

Okay. Thank you.

And our next question comes from Tim Evans from Wells Fargo. Please go ahead.

Thank you. I don't want to neglect the desktop lines – benchtop lines rather. Can you talk about whether your pull-through there was within the guidance ranges for each of those and also comment on the level of placements, were they kind of up, down or flat relative to the back half 2016?

The pull-through numbers were consistent with the ranges that we provided. And the (55:15) numbers were roughly in line with where we expected.

Okay. And then the weakness in Europe, can you just talk – maybe give a little color around that.

The weakness in Europe was primarily driven by the NovaSeq transition and the challenge – they had a good Q1 shipment number last year. I wouldn't call it weakness in Europe. I would call it more they met their forecast and plans.

Okay. Thanks.

And our next question comes from Bryan Brokmeier from Cantor Fitzgerald.

Hi, Bryan.

Hi. Good afternoon. So you mentioned the solid 20% growth in oncology in your prepared remarks. Is a large piece of that growth coming from the TST 170, or if you elaborate on what's the underlying driver of that?

TST 170 is a piece of it, but it's certainly not a big piece of it. I mean, it's a fairly new product to the market. And so you should expect to see that ramp. But in Q1 it was certainly not a big piece of the growth we're seeing. We are continuing to see strength in the translation of market in oncology, driven by the large cancer centers. We talked about the growth we're seeing driven by the adoption of liquid biopsy market of sequencing. So, those are some of the variables that played out much more so than TST 170.

All right. And would you expect that piece of the market to adopt the NovaSeq, and therefore, could there be any sort of a hiccup in oncology as those customers transition over to that system?

I certainly expect over time given that some of the applications we're talking about includes things like very deep sequencing for tumor normal or for liquid biopsies. So, I expect over time, NovaSeq will be attractive to a segment of the market, but we're seeing enough growth from other parts of the market that I'm not sure that you should expect to see a pause in this market at all. I don't think it will just the wholesale adoption of NovaSeq. I mean, there's so many different types of customers that are buying that. I think it will just continue to see growth in that market.

Okay. Thank you very much.

And our next question comes from Catherine from Baird. Please go ahead. Catherine Ramsey Schulte - Robert W. Baird & Co., Inc.: Hi. Hi. Thanks for the question. Catherine Schulte here.

Hi, Catherine. Catherine Ramsey Schulte - Robert W. Baird & Co., Inc.: Are you accepting S4 orders in advance of that launch? Are those included in the 135-order number? And then will you have initial manufacturing constraints for the S4 when it launches or will it immediately be able to meet demand?

The way to think about the 135-order is that people are buying the platform. And initially, they will buy S2 because that's the flow cell that's available, and then they will buy – some of them may buy S4 flow cells when it becomes available. But they're not buying it and then waiting for S4. That's not how they are thinking about it. What was the second part of your question? (58:22) Catherine Ramsey Schulte - Robert W. Baird & Co., Inc.: Will there be initial manufacturing constraints for S4?

I don't think so. I think the bigger constraint will be just on the platform, and that's the constraint that we're working through. I expect that as we bring S4 out, we should be able to ramp up to meet demand. Catherine Ramsey Schulte - Robert W. Baird & Co., Inc.: Okay. And then for NovaSeq orders, can you just describe the cadence of those throughout the quarter and entering the second quarter? I know you had a lot buzz around the JPMorgan Conference, but just talk about how those progressed over time.

Yeah. I think, it is interesting. It's been non-linear. It's probably the best way to describe it in the few days before JPMorgan and in some cases actually in the few hours before JPMorgan, as I had personally reached out to a small set of customers and then a couple of other people reached out to a couple of others. And so we were able to come out of the gate and talk about the commitments we've had from that first set of customers. And so, we were able to come out of the gate and talk about the commitments we had from that first set of customers. For everyone else, including everyone in the Illumina commercial organization, the first time really they heard about NovaSeq was when it was announced on stage at JPMorgan. And so, in some sense that was sort of the starting gun for our entire commercial organization. And we had immediately planned that day a set of training webinars and a marketing campaign ready to go, our road shows that literally took off that week around the globe to start to explain to our field and to our customers what NovaSeq was. And so, we got that initial bolus of customers in the few days and the few hours before JPMorgan. And then we started the sales process. And so, it's a period when we weren't getting any orders because we were still teaching our own team and teaching the rest of the world what NovaSeq was. And so, that started to play out in the weeks after we launched. And so it really started to come to fruition, if you like, in March primarily where those conversations started to play out into orders. I mean, roughly, obviously, there are exceptions, but that's roughly how it played out. Catherine Ramsey Schulte - Robert W. Baird & Co., Inc.: Great. Really helpful. Thank you.

And that concludes our question-and-answer session. I'll now turn the call back over to Rebecca Chambers for final remarks.

Thank you, everyone, for joining us this afternoon. As a reminder, a replay of this call will be available as a webcast in the Investor section of website, as well as through the dial-in instructions contained in today's earnings release. This concludes our call, and we look forward to our next update following the close of the second fiscal quarter.

Thank you. Ladies and gentlemen, this concludes today's conference. Thank you for participating and you may now disconnect.