Good afternoon, and welcome to our Third Quarter 2023 Earnings Call. As a reminder, this call is being recorded and all attendees are in a listen-only mode. We will open the call for questions and answers after our management’s presentation. A webcast replay of today’s conference call will be available on our website at lanternpharma.com shortly after the call. We issued a press release after market close today summarizing our financial results and progress across the company for the third quarter ended September 30, 2023. A copy of this release is available through our website at lanternpharma.com where you will also find a link to the slides management will be referencing on today’s call. We would like to remind everyone that remarks about future expectations, performance, estimates and prospects constitute forward-looking statements for purposes of safe harbor provisions under the Private Securities Litigation Reform Act of 1995. Lantern Pharma cautions that these forward-looking statements are subject to risks and uncertainties that may cause actual results to differ materially from those anticipated. A number of factors could cause actual results to differ materially from those indicated by forward-looking statements, including results of clinical trials and the impact of competition. Additional information concerning factors that could cause actual results to differ materially from those in the forward-looking statements can be found in our annual report on Form 10-K for the year ended December 31, 2022, which is on file with the SEC and available on our website. Forward-looking statements made on this conference call are as of today, November 8, 2023, and Lantern Pharma does not intend to update any of these forward-looking statements to reflect events from circumstances that occur after today, unless required by law. The webcast replay of the conference call and webinar will be available on Lantern’s website. On today’s webcast, we have Lantern Pharma’s CEO, Panna Sharma; and CFO, David Margrave, Panna will start things off with an overview of Lantern’s strategy and business model and highlight recent achievements in our operations, after which David will discuss our financial results. This will be followed by some concluding comments from Panna, and then we’ll open the call for Q&A. I’d now like to turn the call over to Panna Sharma, President and CEO of Lantern Pharma. Panna, please go ahead.

Thank you. Hello, everyone, and thank you for joining us this afternoon to hear about our third quarter results and corporate progress. We made significant strides over this past quarter and executing our mission of transforming the oncology drug discovery and development process, especially now that we have all of our clinical stage drug candidates in human clinical trials that are active, two that are in Phase 1 now and one that is in Phase II. We also continue to make significant progress in the launch of our CNS and brain cancer focused subsidiary, Starlight Therapeutics and in developing the next major leg of our discovery and development efforts, which will be focused on drug conjugates, including antibody drug conjugates. Our team and many clinicians are particularly excited about the interesting first-in-human drug candidates, LP-184 and LP-284. Both of these candidates share a mechanism called synthetic lethality. During Q2, I was able to share the news that we launched LP-184 into a Phase I clinical trial for recurrent advanced solid tumors, especially those that are refractory to current standard of care therapies. This area is an area of especially critical need. During Q3, we launched the sister drug candidate, LP-284, into a clinical trial for recurrent non-Hodgkin’s lymphomas and also sarcomas. We also dosed the initial patient for LP-184 this quarter. Additionally, we continue to enhance and develop our AI platform, RADR. Our AI platform is revolutionizing the way we model, predict and understand drug cancer interactions, enabling us to advance our newly developed drug programs from initial insights, the first in human clinical trials and an average of less than 2.5 years, and it cost of under $2 million per program. So milestone unheard of in the realm of oncology drug discovery. Computational and AI-driven approaches are increasing their…

Thank you, Panna, and good afternoon, everyone. I will now share some financial highlights from our third quarter ended September 30, 2023. Our general and administrative expenses were approximately $1.3 million for the third quarter of 2023, down slightly from approximately $1.4 million in the prior year period. R&D expenses were approximately $2.2 million for the third quarter of 2023, up from approximately $0.7 million or in the third quarter of 2022. A substantial portion of the R&D increase in 2023 relative to 2022 is related to a $935,000 payment received from a service provider in July 2022 to resolve the difference of views in the service provider agreement, which reduced our research and development expenses during the third quarter of 2022. The increase in Q3 2023 was also attributable to increases in product candidate manufacturing expenses, increases in research studies and increases in payroll and compensation expenses. We recorded a net loss of approximately $3.2 million for the third quarter of 2023 or $0.29 per share compared to a net loss of approximately $2.3 million or $0.21 per share for the third quarter of 2022. Our loss from operations in the third quarter of 2023 was partially offset by interest income and other income net, totaling approximately $362,000. Our interest income and other income net increased by an aggregate of approximately $482,000 for the third quarter of 2023 compared to the third quarter of 2022. This increase was attributable to an increase in interest of approximately $194,000 increases in dividend income of approximately $152,000 and an increase in unrealized gains on investments of approximately $102,000. As of September 30, 2023, we had approximately 10.87 million shares of common stock outstanding, outstanding warrants to purchase approximately 177,998 shares and outstanding options to purchase approximately 1.1 million shares. These warrants and…

Thank you, David. This past quarter, we launched another first-in-human Phase I program with LP-284, a novel synthetically lethal small-molecule in refractory non-Hodgkin’s lymphomas and sarcomas where there is a significant patient need for improved therapies. As I mentioned on our second quarter call, we had planned to launch this trial here in Q4, and that’s our current, we’re on track to do that. So we’ve launched both 184 and 284, 1 quarter after another, which is what we had talked about earlier this year. Now 284 can work effectively both as monotherapy or in combination with other standard of care agents. But finding needs are as critically needed and important in cancer and can oftentimes take months or years of lab work. But computational approaches are increasing their ability to predict meaningful and clinically relevant combination regimens for cancer. And our team continues to increase the value of our platform in this regard, and it helps us sharpen the focus of our existing clinical drug candidates to very specific populations. With 284, we were able to understand that advanced non-Hodgkin’s lymphoma cancer subtypes with DNA damage response deficiency, notably those with compromised functioning of the ATM gene, the Ataxia gene, the ATM can cause a tremendous amount of sensitivity to our drug agent. In the U.S., Europe, mantle cell, double hit and other high-grade B cell lymphomas are diagnosed in about 16,000 to 20,000 patients each year and have an estimated annual market potential of $3 billion to $4 billion. We also saw with this drug candidate that in PDX models of high-grade B cell lymphomas, LP-284 showed synergistic and significantly enhanced anticancer activity when used in combination with rituximab. In in-vivo PDX models, the synergy of rituximab with our drug LP-284 was 63% more effective in destroying high-grade…

Yes, we’ve got a couple of questions already teed up, which is great. We’ll go first question from John. This question I’ll repeat it. As you move past the Phase I trial for LP-184 do anticipate refining the indication what will guide efforts to narrow it down? Well, that’s a great question. We will be taking liquid biopsy from the patients in Phase I and obviously some other PK/PD data as well, and we think that will help us refine it. And since it is a basket trial, we do expect there to be a range of response and that also will help us guide. Is there a new higher levels of PTGR1 or is a bigger genomic signature for homologous repair deficiency or nucleotide excision deficiency, I mean a better response? Are we getting a muted response in certain cancers versus a higher response than other. But you have the Phase I data, since it’s a basket design we allow all solid tumors that are refractory we’ll be obviously doing a lot of biomarker work on the – what’s called FFPE slides and also on liquid biopsy. So yes, this will be a very data-heavy even in Phase I. The second question, could you provide – I read the question came in. Could you provide guidance for when you expect to secure initial data from Harmonic Phase I studies for LP-184, 284? So just for clarification, Harmonic isn’t Phase II. We expect to have perhaps some initial data in the first half of next year. But we expect that once we reach what’s called 27 events, which we hope to reach by the end of next year, then we’ll be able to give some good data. Now of course, it could happen a lot sooner. And so it will…

Sure, sure. We have an aggregate of over 95 SG patents and pending patent applications. We have a strong patent position in each of our lead product candidate areas for LP-300. We have claims extending into at least 2032 for LP-184, we have claims extending into at least 20 41. And for 284, we have claims extending into at least 20 39. I think one very interesting thing we’ve seen with our RADR platform is that it’s also a great generator of new insights that you can then use to further expand your IP position. And we expect to continue that. So we are actively filing. As you saw, we described what we did in Q3. We will be actively filing and further building our IP position in coming quarters as well.

Thanks, David. Another question we have from Sean. Sean, thanks for your question. His question, what are your expectations around the pace of RADAR data accumulation in 2024 as you look beyond the 50 billion data points anticipated by end of 2023? That’s a really good question. It’s a very exciting question. Well, I think we’ll have a talk sometime in January or maybe early February, specifically around our RADR platform. But I think we’ll probably pass $50 billion in the next month or 2 easily. And we’re developing internal goals, but we’re thinking kind of a 3 to 4 increase for next year. So we’re looking at – we’ll probably easily get to $100 billion. So we’ll double that number, maybe get to $150 billion to $200 billion. A lot of this is going to depend on what the quality of data sets are. We have a couple of initiatives internally. Again, we’ll talk about them later, around engineered data sets and extracting data from data that’s already available. Second, we’re also thinking about scraping, doing large-scale automated scraping from the right kind of quality publications. And we’re also looking at better and automated feeds from some of the existing more enlightened publications and systems that are doing machine-readable data format, machine-ready kind of data extractions look like through JSON files or other kind of configurations. So we have a number of things, I think we’re going to crush that $50 billion number next year, I think it could be a quarter at least 2 and maybe up to 4x that. But yes, it’s a great question. And more importantly, it’s not just the data, it’s really the normalization and curation of the data and then, of course, the algorithms so you can make sense of all that data. Well, with that, I would like to thank everyone for participating. I know we had a lot of really good questions. And there being no further questions. We’d like to conclude today’s call. Thank you.

Thanks, everybody.