Maher Masoud
Analyst · BTIG. Your line is open.
Yes, absolutely. You are right. So, these are regulatory approvals. That would be whether it’s in the U.S. or in Europe, whichever occurs first. But most likely, it’s always in the U.S. Let me walk you through a little bit. So, for 20 – the reason we are saying in ‘27 we could have potentially five approved therapies is there are three programs currently about to enter potential pivotal start in ‘25 and then we have actually, it’s almost four programs that will be pivotal starting ‘25, and we have one program currently in a Phase 3. So, when you look at it and you do the timeline as to what potentially they can be approved in, conservatively, I think we are looking at ‘27 for those programs. Same thing thereafter, we have other programs. They will be entering into pivotal a few years thereafter. Some of them 1 year, ‘26, or ‘27 is when they are entering into pivotal. So, that’s where we are projecting that we would have additional approvals back 2 you s or 3 years after that, so to speak. But really, if you look at the near-term, you are looking at three to four programs in a pivotal start in ‘25, one program right now in a Phase 3. If you do the math, you are looking at approvals starting in ‘27. Now, in terms of the probability of success, that’s tough for us to do, very tough for us to do because, obviously, if we could do that, we would be in a different line of business, I guess. But it’s – the one thing that we talked about, I think on our last earnings call, the beauty of the cell therapy market is, you will get insight as to whether there is efficacy possibly sooner than other modalities, right. You can see efficacy with patients and, oftentimes, with a fewer number of patients. So, we will – hopefully, we will get more clarity when these – when the therapies begin their pivotal starts in ‘25. If we see efficacy, obviously, then we will see it sooner than anticipated. But we feel confident that there are five potentially in ‘27 and then, thereafter, we can have an additional five going into a few years after that.