Good morning, everyone, and thank you for joining us this morning and for standing by. I'd like to take this opportunity to welcome you all to the I-Mab Biopharma Mid-Year 2023 Financial Results and Business Update Conference Call. My name is Tyler Ehler, and I'm I-Mab's Senior Director for Investor Relations. At this time, all participants are in a listen-only mode. At end of this call, we will conduct a Q&A session and instructions will follow at that time. Earlier today, we issued a press release providing a review of our financial results for the mid-year ended June 30, 2023, as well as an overview of our recent corporate highlights and upcoming milestones. The press release can be accessed on the Investor Relations tab on our website at ir.i-mabbiopharma.com. Joining me today on the call from I-Mab’s senior management team are Raj Kannan, CEO; Dr. John Hayslip, Chief Medical Officer; Dr. Andrew Zhu, President and Head of R&D; and Richard Yeh, Interim CFO and COO. Raj will provide a high-level overview of our recent achievements and upcoming milestones, and John will provide an update on our R&D progress. Richard will then provide a summary of our financial results for the six months ended June 30, 2023, before we turn the call over to Raj for a few final comments. And then back to the operator to take your questions. Please note that today's discussion will contain forward-looking statements relating to the company's future performance and the forward-looking statements are made under the safe harbor provisions of the US Private Securities Litigation Reform Act of 1995. Such statements are not guarantees of future performance and are subject to certain risks and uncertainties, assumptions and other factors. Some of these risks are beyond the company's control and could cause actual results to…

Thank you, Tyler, and good morning, everyone, and thank you for joining us. It has been an energizing few weeks for me since I came on board as CEO in June. I came to this new role with much confidence in I-Mab’s innovative programs and an understanding that we have a great deal of work ahead of us. Today, I'm pleased to speak with you and set out a clear direction for I-Mab that could potentially unlock the significant inherent value that I see in this company for our shareholders. During our call, I will provide you with a high-level update on our performance in the first half of 2023 and importantly, frame our strategic direction and plan. I will ask John Hayslip, our Chief Medical Officer, to provide you with an update on the two prioritized clinical assets in oncology that we plan to rapidly advance in the US and globally and finally, review the recently released positive Phase 3 results from our lead program in China. Richard Yeh, our Interim Chief Financial Officer, will review the financial results for the first six months of 2023 and then hand it back to me for closing remarks. The first eight months of 2023 have been productive for I-Mab. We made significant progress on our innovative assets, including uliledlimab, our differentiated CD73 antibody, givastomig, our novel Claudin 18.2 and 4-1BB bispecific antibody and eftansomatropin alfa, our long-acting human growth hormone that reported out positive Phase 3 results today. As we look to building out the future for I-Mab, we plan to focus on three strategic pillars. First, rapidly advance our two promising clinical assets globally within oncology. Two, maintain our strong balance sheet. And three, focus on establishing a new operating model to become a US-based global biotech company. Taking them…

Thank you, Raj, and good day to everyone on the call. My name is John Hayslip, and I'm pleased to provide you with a clinical overview. First, I'd like to provide updates about uliledlimab, our CD73 targeting antibody designed to block a key pathway that tumor cells may use to evade the immune system, adenosine production. As previously reported, uliledlimab is differentiated by design to avoid hook effect biology, which is a potential liability of other competitor drugs in development. Simply put, the hook effect may prevent other drugs from achieving complete inhibition of enzyme function. The uliledlimab is designed to allow up to 100% inhibition due to its unique functionality. At the American Society of Clinical Oncology Meeting in June of this year, we shared encouraging clinical and translational findings from a Phase 1b/2 study indicating patients with advanced non-small cell lung cancer receiving uliledlimab and PD-1 inhibitor toripalimab. Uliledlimab was well tolerated using an every three-week dosing regimen in combination with toripalimab. Most treatment-related adverse events were Grade 1 or 2 in severity. In the 67 efficacy evaluable patients, the objective response rate, or ORR, was 31%, regardless of CD73 or PD-L1 expression. Notably, patients whose tumors had high levels of CD73 expression experienced a higher response rate than those with lower CD73 expression. The response rate increased to 63% in patients who had both high levels of CD73 expression and a PD-L1 tumor proportion score, or TPS, of greater or equal to 1%, whereas patients with low CD73 expression had an ORR of [28%] (ph). We are excited by these preliminary findings of a correlation between higher CD73 expression and an increased response rate. With this chemotherapy-free uliledlimab and checkpoint inhibitor combination. Data from other studies have suggested that chemotherapy may increase CD73 expression in cancer cells,…

Thank you, John. Now I will review our first half 2023 financial results. As of June 30, 2023, the company had cash, cash equivalent, restricted cash and short-term investment of RMB3 billion or $414.6 million compared with $489 million as of December 31, 2022. I-Mab's strong cash balance is estimated to provide the company with adequate funding to support the execution of the company's strategic plan. As you may have seen today, we also announced that the Board has authorized a stock repurchase program of up to $40 million to enhance shareholder value of the company. Total revenue for the first six months of 2023 were $2.7 million compared with $7.7 million for the same period in 2022. Revenue consists of revenues recognized in connection with the strategic collaboration with AbbVie and the revenues generated from the supply of investigational products to AbbVie and Human Immuno Biosciences or HI-Bio. Now let me turn to the R&D expenses. Research and development expenses for the first six months of 2023 were $61.6 million compared with $67.6 million for the same period in 2022. The decrease was primarily due to the reduced payroll expenses and share-based compensation expenses, partially offset by a slight increase in Chemistry, Manufacturing and Controls service fees. Administrative expenses for the first six months of 2023 were $33.8 million compared with $54.1 million for the same period in 2022. The decrease was primarily due to lower payroll expenses and share-based compensation expenses and related to management personnel and lower expenses for professional services. Non-GAAP adjusted net loss, which excludes share-based compensation expenses for the first six months of 2023 was $87.5 million compared with $116.9 million for the comparable period in 2022. As of June 30, 2023, I-Mab has approximately 190 million shares outstanding. I would like to reiterate our strong cash position of $414.6 million as of June 30, 2023, which allow us to execute our strategic plan. Lastly, please note that the conversion of certain RMB amounts into US dollars for historical periods presented in this call may not be identical to the ones that previously announced due to the differences in particular exchange rate used by the company for this one compared to the historical exchange rates. With that, I would like to turn the call over to Raj for the few closing remarks. Raj?

Thank you, Richard. To conclude, I'm even more convinced than before that I made the right choice to join I-Mab and that we're on the right track with the strategic plan. Looking ahead, we intend to advance our two lead oncology assets, uliledlimab and givastomig rapidly into initial studies in the US and beyond in the first half of 2024. We plan to maintain our strong balance sheet by continuing to streamline and rationalize our spend to advance the most promising programs and we intend to focus on a new operating model to establish a US-based global biotech company with the full support of the Board. We're excited about I-Mab's new strategic plan and look forward to providing you with periodic updates on our progress. Thank you all for taking the time to join us today. I'll now turn the call over to Tyler for the Q&A session.

Thank you, Raj. [Operator Instructions] I would like to direct our first question to Kelly Shi. Kelly, please go ahead.

Thank you, Tyler. And congrats on the great progress and thank you for taking my questions. Firstly, could you comment on the safety profile of your weekly injected growth hormone from Phase 3 trial and in comparison to other competitor weekly programs? And also, could you let us know the projected timeline for regulatory approval and also commercial launch? And I also have a follow-up. Thanks.

Yeah. Kelly, thank you for that question. We are quite excited about the potential of eftansomatropin alfa as a weekly option for our patients. And given the strong results that we just disseminated, I believe this will be a valuable option in the China market, especially in a growing multibillion-dollar growth hormone market. I think I'll let John comment on it. And then Andrew, if you wanted to comment more on Kelly's question and how it compares to other drugs in development, that would be great. John?

Yeah. Thank you, Raj. Thank you, Kelly, for the question. As Raj mentioned, this trial is a randomized head-to-head trial against Novo Nordisk's Norditropin. And as we review the results coming in from this trial, we're quite pleased by the safety profile that we've observed in this trial as compared to Norditropin. In addition, I think we're pleased with how the safety profile of this drug looks compared to other drugs in the field and we look forward to disclosing those more completely in the future as we disclose the full data set. I'd like to ask Andrew, if you'd like to add any additional comments.

Andrew, are you on?

Yes, can you hear me?

Yeah, we can hear you.

Yeah. Kelly, thank you for the question. As you know, we just actually released the results. All the secondary endpoints, including safety and also various variables of the clinical data are being actively analyzed. And right now, we can definitely say the safety profile compare very, very comparable to the weekly injection. And definitely, we will share the data very, very soon. With regard to the second part of the question, we are actively pursuing the BLA submission. Definitely, we think with the Phase 3 data this provide the solid foundation for us to engage this process. And obviously, we're starting the engagement with regulatory agency. So hopefully, we will have additional timeline to report soon. Thank you.

Andrew, I just wanted to make one clarification. I think the safety profile compared very favorably to the once-daily injection Norditropin.

Thank you for your question, Kelly. With that, I would like to direct the next question to Joe Catanzaro. Joe, please go ahead.

Hey, guys. Hopefully, you can hear me okay. I guess I had two questions. Maybe first one on givastomig and particularly as it relates to Claudin expression levels. Wondering with the potential approval of zolbetuximab, I guess, next year, whether based on what you've seen thus far, whether there's opportunity to maybe capture a broader Claudin expression range with givastomig? Thanks, and I have a follow-up.

Thanks, Joe. As you can tell, we're very excited about this particular program, including our TJ-L14B that we're collaborating with ABL Bio. But in particular, we continue to believe that givastomig is quite differentiated from the agents that are in development. I'll ask John to comment more on the specific area of Claudin 18.2 that you specifically referred to. John?

Yeah. Thank you, Joe. So, as I alluded to in my comments, in a non-clinical time, early in the development of givastomig, we've seen that givastomig can be efficacious have biologic effect down to very low levels of Claudin expression. And in addition, you'll see in our clinical data, we've seen clinical benefit in patients who have quite low levels of Claudin expression. So we're optimistic -- the program is early still, but we're optimistic that givastomig may be able to bring benefit to a broader and much broader group of patients with lower Claudin 18.2 expression as well.

Great. That’s helpful. And maybe my follow-up question quickly on lemzoparlimab in the ongoing Phase 3 trial in MDS in China, because it sounds like there's a lot of considerations there and the maybe situation is fluid. But I guess now knowing the outcome of magrolimab's ENHANCE trial, just wondering how you think about what ultimately we could see from that trial and how it influence your decision with lemzoparlimab and its clinical strategy? Thanks.

Thanks, Joe, for that question. I think this was an intensive discussion as well within the company, as you can imagine, with the recent results from the other CD47 targeting agents. I think it will be premature for us to make a decision on our molecule. We continue to believe that our molecule is differentiated. And we continue to enroll in our ongoing Phase 3 study in China. We do plan to review interim data early next year and complete an advisory panel to review all of the class data as it becomes available. and to compare what we have and then I would think our shareholders would appreciate that to make an informed decision in the first half of next year in advancing the molecule. So we'll certainly further analyze the details of the ENHANCE study as well as the data becomes available in the public markets.

Okay. Perfect. Appreciate you taking my questions. Thanks so much.

Thanks, Joe.

Thank you, Joe. I'd like to direct the next question to Louise Chen. Louise, please go ahead.

Hi, thank you for taking my questions here and congratulations on the progress this quarter. So Raj, I wanted to ask you if you could elaborate more on your vision for I-Mab and how long it will take you to reach your objectives? Secondly, on CD47 again, just curious where you stand with your outside of China opportunity with AbbVie here and when you might reveal more details on your next-generation CD47 or is that project on hold right now? And then I know you've mentioned the givastomig ESMO presentation, but are there any other important data presentations throughout the end of the year at health care conferences that should be on our radar? Thank you.

Yep. Thank you, Louise, for all those questions. I'm going to remember every one of them as much as possible. And if I do forget, please reiterate it. We were practically writing those questions down. So the first one is what's the timeline that I expect to deliver on the strategic objectives or the plan that I laid out? I think as you will see in the next couple of years, there's quite a few catalysts that are going to become available to our stakeholders. And so I think I give myself 24 months to be able to start looking at the strategic plan and the progress that we've made. So that will be an important timeline for investors to understand that this is not going to happen overnight, but the shift in the focus and how we're thinking about making into a US-based global biotech is going to take time. But again, I think if I had to put pen to paper and think about a timeline that should be important, it should be by the end of 2025, second half of 2025, we should be in a good position to look back and say, how is our strategy working and how is it enhancing the value for our shareholders. So that was the first question, I believe, Louise. The second question is on lemzo outside of China. As you can imagine, as we've said before, right, that AbbVie had terminated the development, global development of lemzo, but we have the rights to China. So we continue the trial in China. At this time, we have no plans to initiate a study until we see the interim data, we analyze the class data of the other CD47 targeting agents, and we meet with an expert panel to be able to understand if our molecule is truly differentiated from the other CD47, and we can come back at that time, Louise, to clearly articulate as to if we're going to move forward with lemzo or the backup compound. And then the last question, Louise, was on the -- sorry...

Conferences. Anything on the -- aside from ESMO, I know you mentioned givastomig from ESMO, but any other of your main compounds going to be presenting new data at conferences throughout the remainder of the year?

As far as we know, I don't think there's anything that jumped out to us for the rest of the year, but I'll let John comment on it. John?

Yeah. Thank you. So as we mentioned, we plan to present the givastomig dose escalation clinical findings at the European Society of Medical Oncology in October this year. Also, as I mentioned, we anticipate the dose expansion cohort, the continued enrollment of patients with gastric GEJ, and esophageal cancer. We expect to have interim results early next year from that cohort of patients. So we'll be reviewing those results and bringing those forward as quickly as possible. But for the remainder of 2023, no additional conferences to add at this time.

Okay. Great. Thank you very much.

Thank you, Louise.

Thank you, Louise. The next question we will direct to Ethan Markowski. Ethan, please go ahead.

Hi, everyone. This is actually Gil, not Ethan. So maybe a quick one on the commercial opportunity for eftan. Are you guys thinking of pricing it similar to the current standard of care in China, if you had any thoughts there?

Hi, Gil. I think it would be a little premature right now to comment on price. But I do know that we're excited about the profile of the compound itself in terms of the benefit that it could bring to patients. And we're excited about the growing large commercial opportunity that we have available for the human growth hormone product. So I think we're going to price it competitively. I can definitely assure you that, but I think it's a little too early for us to actually comment on price publicly before we've even filed the product.

Okay. And maybe a quick biology question on givastomig. So signaling for 4-1BB usually requires trimerization of the ligand, which links to these weird-looking bell curves, a little bit like the hook effect. I'm just wondering, have you seen that in preclinical studies with givastomig or is this even an issue? Thank you.

John, do you want to take that?

Sure. Yeah. Thanks, Gil. Good to hear from you. So this has not been a non-clinical -- is not a preclinical issue for givastomig. And further in the early clinical findings, we continue to see systemic pharmacodynamic effect of soluble 4-1BB in a predictive manner. So we've been quite confident about what we've observed today with givastomig regarding the PD effect.

[Indiscernible] questions.

Thank you, Gil.

Next up, I would like to direct the next question to Andres Maldonado. Andres, please go ahead.

Hi, thank you very much for taking my questions and congrats on the progress. Just one quick one, maybe for Raj from us. Could you elaborate on where do any initiatives for finding commercial pipeline -- commercial partnerships for the pipeline fall with your new vision for the company? Obviously, prior to you joining. There was a lot of talk on partnering uliledlimab. I'm curious on your thoughts on the potential for partnerships outside of uliledlimab and how they align with your vision? Thank you.

Yep. Thank you for that question. I think as I look within the company and talk with my colleagues in R&D and in business development, we're very excited about our assets. And we think they have interesting biology. They have produced early encouraging clinical data. And I think we have a very healthy balance sheet to be able to take them forward on our own at this time. I think it will be -- in my estimation, premature to start talking about partnering until we actually produce mature data, either proof of concept or the ability to actually have a higher probability of success in taking these to market. And I think that, that time would be ideal to talk about if appropriate, depending on what else do we have in terms of opportunities to be able to talk about do we need a partner and why? But I will say also as a note, we continue to get incoming inquiries of interest on these assets, and we continue to engage with these outside partners. But that doesn't mean that we are keen on partnering until it makes strategic sense, and we believe that, that option produces the highest value for our shareholders in the near to midterm.

Thank you for your question, Andres.

Does that answer your question, Andres?

Yes. Thank you very much.

Thank you.

I'd like to direct the next question to Qu Xiaoyi. Xiaoyi, please go ahead.

Hi, this is Xiaoyi from CICC, and thanks for taking my question. I have a quick one on the CD73 antibody. So we see very encouraging results of this antibody in first-line non-small cell lung cancer. And in the 1b/2 Phase I2 trial, there are about 60-ish patients that has both high CD73 and PD-L1 expression, and the ORR reaches really high for this population. Do you predict similar percentage of target patient population in the real world? Or like what's the target population like in average for this -- both like double positive expressing patient population in the real world? And also for the pivotal trial, I just want to ask about the design for this trial. I see like for the patients that with really low TPS expression, you see like the response is minimal. And by adding the chemo on top of the immune checkpoint inhibitors, do you see any evidence preclinically or clinically that adding chemo can boost the sensitivity of these PD-L1 active patients in the response to CD73?

Yep, Xiaoyi, that’s very good questions on uli. Let me just take the first comment, and then I'll pass it on to John. I think all of the results that we've generated in the program to date give us the confidence, especially in advancing that program in the settings that John articulated in his prepared remarks. So I think our intent would be to go to a broader group of patients while we will continue to assess the PD-L1 status and CD73 status, but that's just a subset of what we would be focused on. John, do you want to comment more on that and the second question that she had?

Yeah. I would just add that we've been working with WuXi Diagnostics throughout the development program regarding the CD73 biomarker assay. And so the trial that we reported, we enrolled -- we allowed patients to enroll who had newly diagnosed non-small cell lung cancer who were not eligible or who refused to receive chemotherapy. In other words, the patients were allowed to enroll before they even knew their CD73 expression. So CD73 expression to the broader group, that was not an entry criteria. So we would believe we're within the setting of a modest-sized clinical trial. The rates that we observed may be consistent with what we would generally observe in future studies. So of course, the precision around that, we need larger studies to increase our confidence. So I think the rates are -- I think that's what we know about the rates of the double high population. But as Raj said, importantly, as we move the program forward, we do see, as you mentioned, with checkpoint inhibitors, which themselves are not so efficacious as monotherapy for patients with lower PD-L1 expression. But when you combine checkpoint inhibitors with chemotherapy, then the benefit of checkpoint inhibitors expands to the really the broad population of newly diagnosed patients of lung cancer. And so we're optimistic that as we move forward in combinations with chemotherapy, that, that similar -- that rates of benefit like that may extend to the broader patient population and not just those who were elevated prior to the initiation of treatment.

Thank you for your question, Xiaoyi. I'd like to direct the next question to Bing Zhao. Bing, please go ahead.

Yeah. Thank you for taking my questions. This is Bing Zhao from China Renaissance. I'm still interesting about the call the Claudin18.2 and 4-1BB bispecific antibody. Because I realize that the status Claudin 18.2 8. antibody is going to be listened in US, probably second half of this year. And also Astellas is looking for listing in China Mainland as well. So I'm wondering if their products being commercialized, what is affected our future clinical plan? And also, I realize that for Claudin -- for biospecific antibody, there are many combinations on the market, let's say, for example, Claudin 18.2 is with CD3 or Claudin with PD-L1, but I'm interested to know more biologics behind why we choose the Claudin and 4-1BB instead of the other targets? Thank you.

Thank you for your question, Bing Zhao. I think as we -- as you're talking about the positive is there's a lot of interest in the Claudin 18.2 space itself. It's a highly relevant tumor antigen. And as you said, there's a lot of work going on. And we're excited about the differentiation that givastomig has, as we articulated in our prepared remarks, John, do you want to specifically address some of the differences that givastomig to what Bing Zhao brought up in his question?

Yeah. Thank you. So maybe first, I'll just touch upon, we are aware of a lot of the work being done in the field. And I'll just first touch on CAR-T cell therapies, which may hold significant potential. The cost and tolerability may relegate that approach to patients who have received previous treatments in the past. Similarly, we have seen some early reports from ADC type therapies and some of those with encouraging results. But really, we think it's too early to know about those drugs if they'll eventually get to the market or not. And in the past, for example, ADC-type drugs have not always combined well with established treatments. And therefore, are sometimes used after established treatments have been exhausted. Maybe just finally, to touch on the monoclonal antibodies in development, which you mentioned and which may commercialize in the next year or so. These results are indeed important. But as I mentioned earlier, we look for givastomig. We're about to begin combination studies. We intend to study with chemotherapy and with checkpoint inhibitors. And as I mentioned also, we've seen benefit in even monotherapy in patients across a wide range of Claudin expression, including patients with quite low expression have received monotherapy benefit. So we're quite encouraged by what we've seen to date with givastomig and the ability that givastomig could help address the unmet needs for a wide range of patients. and look forward to initiating those studies to combine with current standard frontline treatments.

Hey, Raj, could I add one point to John's comments?

Sure Andrew. Sure.

Yeah. So Bing, you're obviously touching a very, very critical point. We are fully aware of the competitive landscape in the Claudin targeting area. However, as John pointed out, I think definitely our drug can actually cover a broad range of clouding expression level. And the second attractive feature is really the safety profile. As you know, for zolbetuximab and all the Claudin targeted native antibodies, they have the class specific toxicity profile. In particular, the GI side effects is actually quite challenging for the clinicians to manage. So our data so far really highlight the favorable safety profile of givastomig. So I think combined with these two features, I think even in the first-line setting, even with the pending zolbetuximab approval, we still think we can actually position our drug very broadly in the first-line gastric esophageal space just because of the broader [indiscernible] with Claudine expression as well as the favorable safety profile. Just want to clarify that point.

And I think -- just one other thing I just wanted to say is, right, we will have more details of the data presented at ESMO, which will be interesting as well for you to take note of.

Yep. Thanks.

Thank you, Bing. Next question. I'd like to direct it to Zhuxuan Jiang. Zhuxuan, please go ahead.

Okay. So, thank you very much for this chance. And my question is about our early-stage pipeline development. So could you elaborate more about the pipelines that are going to enter the R&D stage? Thank you.

Yeah. So great question. I think the early pipeline in China has been -- the China, specifically the talent in China has been a complete foundation and a core driver for innovation in how I-Mab has progressed to date. That being said, I think as you look -- hear the prepared remarks that we have today and the shift and the focus and the strategy is to really focus on those drugs that are in the clinic today to be able to accelerate the development and bring it to market. I think that is a huge shift. While we will continue to look at assets in the earlier stage right now in terms of shareholders and value inflection, we're looking at the next two to five years in terms of how we can maximize the value of the company for our shareholders who have been with us for these years, right? So you'll see more information as we progress the late-stage compounds. We feel comfortable on the likelihood and the success of those compounds getting to market, and we're participating in the market, you'll see more data on how we start focusing on preclinical and early stage compounds. Does that answer your question?

Yes, thank you.

Thank you, Zhuxuan. We will take one last quick question. We have three minutes left. I would like to direct the last question to [indiscernible]. Please go ahead.

This is [indiscernible] from Citi Research, and thank you for taking my question. And I have two more questions. One, the first one is about the CD47 projects. And we know that the [Gilead and Bayer Oncology] (ph) just terminated their project due to limited efficacy. So could you give us more color on the efficacy gap between the Phase 2 and the Phase 3 trial? And we know the primary endpoint for our Phase 3 trial is overall survival. And can you comment more about the improvement in the ORR rate to the benefit of the [indiscernible]? And yeah, it's the first question. And the second follow-up, the [indiscernible] project for -- and for the -- for our coming pivotal study, where the regulatory open green lights for single-arm pivotal study or it should be head-to-head Phase 3 study? Thank you.

So thank you for the question on lenzo and then uli as well. So let me just reiterate on the lenzo one, right? So we have seen the announcements from the CD47 targeting companies recently. And as we said, this was obviously a great interest to us in terms of the announcement itself and how that impacts our program. As we said before, I think it's a little premature for us to think about a decision whether we should continue or stop the molecule development. I think we continue to enroll our ongoing Phase 3 study in China. We continue to believe that our molecule is differentiated. But as we said, we are also going to review the interim data. We're going to look at the full data from these CD47 that have announced their trial termination fully and then meet with experts to be able to make an informed decision on CD47. So that, I think, is a crux of how we're thinking about our program. As we said, this is only in China. We are not progressing with lenzo anywhere else outside of China until we get that information in our hand. On the uli question, let me pass it on to John to address that question in particular.

Thank you, Raj. So I'd just add regarding uliledlimab and the potential development pathways. We have the utmost respect for the regulatory agencies. Certainly, they have a challenging task and regulatory guidance changes from time to time. So at this point, we would not comment further regarding the specific regulatory pathway for uliledlimab until after we've reached alignment with the right regulators. And then we'll speak further about it after that time.

Does that answer your question?

Yes. Thank you.

Thank you. And with that, we're running a little over time, so we will conclude today's call. If there are any follow-up questions, please feel free to reach out to your local IR representative, and we'll get back to you as quick as possible. Thank you, everyone, have a great day.

Thank you.