Good afternoon, and welcome to OmniAb, Inc. First Quarter 2024 Financial Results and Business Update Conference Call. [Operator Instructions] As a reminder, this conference is being recorded. I would now like to turn the call over to Kurt Gustafson, OmniAb, Inc. Chief Financial Officer. You may begin. Thank you.

Thank you, operator, and good afternoon, everyone. This is Kurt Gustafson, OmniAb's Chief Financial Officer. And thank you, all, for joining our first quarter 2024 financial results conference call. There are slides to accompany today's remarks and they are available in the Investors section of our website at omniab.com. Before we begin, I'd like to remind listeners that comments made during this call will include forward-looking statements within the meaning of the federal securities laws. These forward-looking statements involve risks and uncertainties that could cause actual results to be materially different from any anticipated results. These forward-looking statements are qualified by the cautionary statements contained in today's press release and our SEC filings. Importantly, this conference call contains time-sensitive information that is accurate only as of the date of this live broadcast, today, May 9, 2024. Except as required by law, OmniAb undertakes no obligation to revise or update any forward-looking statements to reflect events or circumstances after the date of this call. Joining me on the call today is Matt Foehr, OmniAb's President and CEO. During today's call, Matt and I will provide highlights on the company's operations, partner and technology updates and our recent financial results. And at the conclusion of our prepared remarks, we'll open the call to questions. With that, I'll turn the call over to Matt.

Thanks, Kurt. Good afternoon, everyone, and thanks for joining us today on our first quarter call. With consecutive quarters showing growth across some key business metrics, I'm proud of OmniAb's progress over the last 18 months, which put us on track for a successful quarter and positions our business and our pipeline very well for a strong year here in 2024. Our performance during the first 3 months of the year reflects both the continued diversification of our partnership base and the expansion of our global presence. OmniAb's team remains highly focused on our strategic plans. We're creating greater visibility for our validated technologies and we're committed to driving innovation to create long-term value for our stakeholders. We're excited about the opportunities that lie ahead and we're confident in our prospects for technology and business growth and progression in the coming years. I'll quickly review our business metrics starting here on Slide #5. We ended Q1 2024 with 80 active partners. 3 new platform license agreements were signed during the quarter, including new agreements with a very well-funded Boston-based venture-backed start-up with ImmunoBiochem Corporation and with the University of Georgia. We're committed to continued expansion of our diverse partnership base. And as you can see here, we've nearly doubled our number of active partners, net of attrition since 2018. Our technology platform continues to become more visible and continues to expand. And with our recent technology launches and plans for continued innovation, we believe we're well positioned to potentially accelerate this growth of partners. We also saw some growth in active programs this quarter net of attrition with a number of active programs increasing to 327, as we show here on Slide #6. We experienced a slightly higher level of program attrition in Q1 as compared to recent quarters, all…

Thank you, Matt. I just have a couple of slides on our financials. So starting on Slide 12, we've got a summary of our financial performance in the first quarter of 2024. Total revenue for the first quarter was $3.8 million compared to $16.9 million in the prior year quarter. The decrease was primarily due to the recognition of the TECVAYLI EU launch milestone of $10 million that was recorded in the first quarter of 2023. Service revenue was lower, primarily related to the completion of our discovery work on certain ion channel programs. First quarter revenue was consistent with our expectations. And you'll recall that on our Q4 earnings call, I stated that we were projecting milestone payments would be weighted towards the second half of the year based on information that we have received from partners in their public statements. This is still our expectation. Turning to operating expense. Our R&D expense for the first quarter was $14.6 million compared to $13.8 million in the prior year quarter, with the increase primarily due to higher personnel costs. On the G&A side, expenses were similar to last year coming in at $8.3 million. Our operating expenses are also tracking in line with our expectations. And we still expect operating expenses in 2024 to be approximately the same as in 2023 as we are now fully staffed and resourced to leverage the future growth of the business. One additional comment about the tax rate, going forward, our deferred tax liabilities are no longer expected to fully cover our deferred tax assets in the future. So we had to establish a valuation allowance and this caused our effective tax rate to drop. In general, we now expect our effective tax rate to be in the low to mid-teens going forward. But this could fluctuate from quarter-to-quarter based on the timing of certain discrete items. The net loss for the first quarter was $19 million or $0.19 per share versus a net loss of $6.1 million or $0.06 per share in the prior year period. Turning to Slide 13. We ended the first quarter of 2024 with $69 million in cash. As we said on our Q4 earnings call, we expected that Q1 would be our largest burn quarter this year due to the timing of milestones and certain compensation cycle items and this played out as we had expected. For the full year, we reaffirm our guidance for cash used to be relatively similar to the cash used in 2023 when you exclude the $35 million TECVAYLI milestone that was received last year. And we still expect that our cash balance and the cash from operations should provide sufficient capital to fund the operations for the foreseeable future. And with that, I'd like to open the call for questions. Operator?

[Operator Instructions] First question comes from Stephen Willey at Stifel.

This is [ Tule ] on for Steve. Congrats on the progress. Before I anticipate -- can you guys hear me okay?

Yes, we can hear you.

So yes, congrats on the progress. And now given that there are multiple, different programs across various stages, right? So can you please make an additional comment on what proportion of those programs actually include downstream participation on the royalty? That's my question number one. And question number two, also Matt mentioned about the potential 4 to 6 new programs entering the clinic this year. Is there any -- like what proportion of those programs are specific to which platform? If potential -- can you provide any additional color on that, please?

Yes. Thanks. I'll maybe make a couple of comments and then Kurt can fill in anything that I missed. In terms of programs that have downstream economics, of our 327 active programs that partners are actively investing in and progressing through discovery and development, [ really ] only a very small portion, about 2% don't have downstream economics and participation to OmniAb. Those -- that -- about 2% of those 327 are legacy licenses that we -- are old licenses that we inherited where partners essentially had a fully paid license to a predecessor company that we acquired. So that's, I think, probably gives you the color you need there. In terms of the 4 to 6 new programs that are entering clinical trials this year, we're actually excited about those. Some are getting very close to the clinic. We expect a couple of those to be OmniChicken-derived. One with a large multinational player and the others will likely be a mix of our source technologies -- our other source technologies. So hopefully, that helps you.

The next question comes from [indiscernible] from Truist Securities.

This is Nishant, I'm on for [ Kripa ]. So I know you don't provide deal terms for like specific partnerships. But just to get a sense of how different the deal terms are -- For example, you signed a deal with University of Georgia and another one with a start-up or a biotech company. So how -- in terms of economics, how these deals are different? Can you provide any color? That would be great? And then, I have a follow-up.

Yes. So I think in terms of -- the way most deals start off, they all kind of start off with the same term sheet and get negotiated from there, so all the terms end up being slightly different. But they're in the same ballpark. And we've provided some guidance in the past about those -- what those look like. I will say, though, that frequently deals with academic institutions are structured slightly different because for the most part, these institutions are not going to take something all the way through clinical development and launch them. And so these deals -- the way the economics are primarily structured is that we would receive kind of a percentage of whatever they would eventually get when they either sell the asset or license it out. And frequently, that percentage may vary depending on how far they took the asset, right, if they license it out in pre-clinical versus Phase 1 versus Phase 2. That percentage could sometimes vary. So I'd say for our commercial companies, there is some variation, but it's not hugely different. And with the academic institutions, just the structure of the deal is a little bit different. So I don't know, Matt, if you have anything to add on that one?

No, I think you covered it well, Kurt.

And then in terms of interest from external partners, like can you provide any color on which platforms are seeing increased interest in the past quarter and specifically the newly launched OmnidAb?

Yes. Nishant, a great question. And we -- because of our, I'll say, clarity of mission and commitment to continued innovation paired with the level of validation of our platforms, our inbound interest is the highest it's ever been in terms of partners approaching us. We've also increased our share of voice, expanded our business development team globally. So that's also, I think, contributing to increased interest in the platform. Our OmnidAb launch has been going very well in terms of leveraging and deploying a new technology. Since we announced the launch of it at the [ AT ] conference late last year, as I said in prepared remarks, we have multiple industry partners as well as academic partners leveraging the platform now. And we're actually really excited about it for a lot of reasons. One, it opens up new opportunities and new markets for us. For our partners, they're attracted to the nature of domain antibodies and what that means in terms of opening up alternate routes of administration, better penetration, fast tunable clearance passing through the blood brain barrier, those sorts of things. So that's attracting a lot of attention from new as well as existing partners. And it also is opening up potential in new markets like imaging and diagnostics and theranostics and the like. So yes, we're excited about it. And I think it's a great time for new technologies and also these discussions also continue to inform how we innovate for the future as well.

The next question comes from Matt Hewitt from Craig-Hallum.

This is Jack on for Matt. The last quarter a year, it seems like others in the industry were struggling to win new business, just given the challenging environment, but you guys were not. Could you just provide us with some color from what you're hearing from?

Yes. Thanks, Jack. It sounds like you might have got cut off there a little bit at the end. But I'll say, look, yes, the last couple of years, I think it's obviously been well documented. 2022 and 2023 were periods where financing was difficult for a lot of biotech companies where I'll say partners both large and small were exercising more cautious pipeline spending, trimming programs and that sort of thing across the industry. That said, if you look at our metrics, all net of attrition, we were able to show really nice growth in terms of new programs and new partners. And I think that really speaks to the technology that we offer partners, our clarity of purpose and our model in terms of collaborating with them. And in those kinds of times like the last couple of years, I think partners really do look to validated technologies and stable and established partners as well as those with a commitment to innovation and meeting their needs to partner. So I think that's a large part of it. I also give a lot of credit to our team, who really have a very partner-first mentality in terms of how we collaborate with our partners. And I think that's driving it as well. So now with -- at the end of last year and early this year with more funding coming into biotech, I think it has the potential to create tailwinds for the industry generally. But we feel really great about the business that we're running and the technology that we offer to partners.

The next question comes from Michael Sontec from Leerink Partners.

[ This is ] [ Michael ] on Puneet. My first question, I guess, has to do a little bit with -- I guess you mentioned with your discovery pipeline and one partner in Asia that were doing cancellations offset by U.S. and Europe. I was kind of curious if you have any perspective on, I guess, the health of the various biotech sectors geographically and I guess what your exposure is to some of these geographies?

Yes, Michael, thanks. We did see in Q1, as I mentioned in prepared remarks that we -- what we saw [ and ] really see as kind of a onetime spike in attrition really related to a single partner in Asia, who was realigning their pipeline of -- and trimming discovery assets. I will say that the new program starts are off to a great pace. We report our numbers net of attrition. We see this more as like a one partner item. I wouldn't see anything that is more related to broader geography or anything like that. We obviously now have expanded our business development team and continue to negotiate new contracts and add new partners as we did in Q1. I don't know, Kurt, anything you'd want to add to that?

I mean I don't think that there's anything from a geography standpoint that -- necessarily that we're seeing. I think, like you said, Matt, at the end of the day, innovative technology is what we hope wins and so far, it looks like its winning.

And then I had another question, I guess, related to the [ biosecure ] bill that's been proposed in Congress. I believe Wuxi is one of the partners that offer OmniRat as a service. I was curious if you have any early thoughts on what biosecure passage might do for the business?

Yes, Michael. So yes, Wuxi, and I'll be specific, Wuxi -- it was Wuxi Biologics. They were a very early user of OmniRat and really only OmniRat via a legacy deal with a predecessor company that we acquired, right? And they have, I think, a very limited number of even active programs ongoing historically. But the legislation that's being debated in Congress is not expected to really have any significant or direct impact on our business. That said, obviously, it's gotten a lot of coverage just given the spot that Wuxi holds in the greater biotech ecosystem. But we don't see it having any impact on any programs that we see as value drivers or really don't see it having any significant impact on our business at all.

Next question comes from [ Jacqueline Cusa ] from Cowen.

This is [ Jacqueline Cusa ] on for Stephen Mah. On the new licenses, can you give us some more color on the therapeutic interest or program size expected from these companies? And then what is the mix regarding platform use? And do you see this shifting as OmnidAb continues to gain more traction?

Yes, Jacqueline. Thanks for the question. Yes, in terms of the new partners that were added in Q1, ImmunoBiochem is a really interesting company. They are [ alumna ] of the Johnson & Johnson J-Labs incubator headquartered up in Toronto. And they're focused on oncology and immuno-oncology, specifically in the micro tumor environment. So our technologies, I think, are really well matched to their areas of interest. And we'll obviously be cheering them on and are cheering them on. The University of Georgia through their innovation gateway incubator are a new partner as well. And that is a partnership that is structured with a revenue share model, as Kurt was describing. And they've got a really interesting history, not only in innovations around infectious diseases, but also in oncology as well. So that is a partner we're excited now to have on board and to be collaborating with. And then the last partner, I mean, there's not much I can say about them. They're a very well-funded Boston-based health venture-backed start-up. I guess all I can say from our perspective, they're a proven team who know our technology and our team well, but that's probably all I can say at this point. I expect they'll be talking more publicly in the future.

And then are there any new updates or releases on OmniDeep we may have missed or can look forward to in the coming quarters? And have you seen any increased interest in the platform? And how has customer feedback been from users?

Yes. No, great question, Jacqueline. In the near term, I direct you to the presentation next week at PEGS. Bob Chen will be presenting data around really marrying the biological intelligence of our transgenic animals and our high-throughput single B cell screening capabilities and technology with exploration with our OmniDeep platform. And really, our OmniDeep platform is a suite of in silico, AI and machine learning tools that are woven throughout our technology stack. And really, the things that our partners are valuing in it is the ability to marry it with high-quality input data from our transgenic animals and the hits that can be generated with exploration, pairing that with variational encoder or VAE deep learning models that we've developed to then suggest new hits and then also leveraging in silico developability filters and things like that. So we are leveraging OmniDeep as part of our offering for our partners, a number of big pharma partners who are leveraging it as well as collaborations with academics and others. So the -- since launching OmniDeep as a brand last May, so really just almost exactly 1 year ago, the reception to that has been really strong as well. We've obviously been in this space for quite a long time, leaning into leveraging AI and machine learning along with our other technologies for many years.

At this time, we have no further questions. I will turn the call back over to the presenters.

Great. Thank you all for joining our call today. We look forward to keeping you updated as the year progresses and as the business progresses. We'll be out on the road quite a bit here over the next few months at a number of conferences and look forward to keeping you updated. Thanks again for joining and have a great day.

Ladies and gentlemen, this concludes your conference for today. We thank you for participating. And we ask that you please disconnect your lines.