Good afternoon, and welcome to the OmniAb Inc. Second Quarter 2025 Financial Results and Business Update Conference Call. [Operator Instructions] As a reminder, this conference is being recorded. I would now like to turn the conference call over to Mr. Kurt Gustafson, OmniAb, Inc.'s Chief Financial Officer. You may begin.

Thank you, operator, and good afternoon, everyone. This is Kurt Gustafson, OmniAb's Chief Financial Officer, and thank you all for joining our second quarter 2025 financial results conference call. There are slides to accompany today's prepared remarks, and they're available in our Investors section of our website at omniab.com. Before we begin, I'd like to remind listeners that comments made during this call by OmniAb's management will include forward- looking statements within the meaning of the federal securities laws. These forward-looking statements involve risks and uncertainties that could cause actual results to be materially different from any anticipated results. These forward-looking statements are qualified by the cautionary statements contained in today's press release and our SEC filings. Importantly, this conference call contains time- sensitive information that is accurate only as of the date of this live broadcast today, August 6, 2025. Except as required by law, OmniAb undertakes no obligation to revise or update any forward-looking statements to reflect events or circumstances after the date of this call. Joining me on the call today is Matt Foehr, OmniAb's President and CEO. And during today's call, we'll provide highlights on the company's business and operations, partner and technology updates as well as our recent financial results and outlook. And at the conclusion of the prepared remarks, we'll open the call to questions. And with that, let me turn the call over to Matt.

Thanks, Kurt. Good afternoon, everyone, and thanks for joining us today on our Q2 call. I'll start now with Slide #4. As I mentioned on our last call, we started the year with strong deal flow, and this continued in the second quarter with a number of new partners added in the first half of the year, setting a pace for one of our strongest years yet. We continue to see a robust pace and quality of deals. And we think this is a testament to our differentiated technology platform, which continues to evolve and expand and to our team's relentless pursuit of innovation that leverages our unique vantage point in the industry. Our partners are actively advancing programs into human trials with the start of a new clinical stage program during the second quarter and several others that are progressing through development. And on the third highlight here on Slide 4, the recent launch of our xPloration Partner Access Program has been very well received with a strong response from existing partners and others. Within weeks of launch, we sold and installed an xPloration system, and we are managing a robust pipeline of leads and business activity for this new technology that's expected to be accretive to the business and to further diversify our sources of revenue. Our platform is attracting new partners and facilitating the addition of new programs. We continue to drive efficiencies in our business through leveraging our technologies, including xPloration and through the streamlining of our business practices, all with the goal of creating long-term and sustainable value for our stakeholders. We've been realigning our staffing needs and recently reduced some costs in our headcount. This is in addition to the staffing realignment we disclosed back in February related specifically to the small-molecule ion channel…

Thanks, Matt. On Slide 14, I'll start with a review of our revenue. For the second quarter of 2025, we reported revenue of $3.9 million compared with $7.6 million for the same period in 2024. The decrease was primarily related to lower milestones achieved in the quarter and lower service revenue. Service revenue declined primarily due to the discontinuation of a small-molecule ion channel program last year, which also resulted in the acceleration of noncash revenue in that quarter, which overinflated last year's number. The decrease was partially offset by the new xPloration revenue this quarter, and this revenue primarily includes the sale of an instrument as well as the sale of various consumables related to the xPloration platform. Slide 15 shows our cost and operating expenses for the second quarter of 2025 which decreased to $20.1 million from $23.9 million for the prior year period. We saw decreases in both R&D and G&A expenses relative to last year, and I'll go into some of those details here on the next slide. So turning to Slide 16 and focusing on operating expense. You'll see a new line item for the costs associated with the xPloration revenue, which were approximately $300,000 this quarter. This represents the costs associated with the manufacturing of the xPloration instrument as well as the related consumables sold in the quarter. Research and development expense was $10.9 million versus $13.9 million a year ago, with the decrease primarily due to lower stock-based compensation, lower headcount as well as lower external expenses associated with small-molecule ion channel programs. G&A expense declined to $7.7 million from $8 million for the same period in 2024, with the decrease primarily due to lower legal fees and lower stock-based compensation expense. The other operating income line includes a gain of $3 million…

[Operator Instructions] And your first question comes from Puneet Souda from Leerink.

You have Micheal on for Puneet today. Congrats on the quarter. My first question has to do with just large pharma versus small biotech trends. So we've heard a lot from CROs talking about small biotech moving forward on their trials. And I'm wondering if you're seeing any of that flow through either positive or negative in terms of your discovery. Any color you can provide there or if it's a completely separate from, I guess, more later stage?

Yes, Micheal, thanks for the question. This is Matt. We've been pleased with the continued growth in both partners and programs. We saw really nice momentum starting to build in that coming out of last year. That obviously has continued, and you can see it in the performance and the numbers through Q2. We've had nice net growth in both partners, right, which is a nice metric of our technologies and their relevance to the industry and how they're attracting new partners as well as programs. We also see a nice mix of large pharma partners starting up new programs as well as smaller players as well. So we're seeing contributions from both as well as academics who are now incubating assets to spin those out into companies. But in terms of your question around small and large, we're seeing it on both -- from both.

Okay. Great. And then a quick question on the guide. I was wondering if the reiterated guide continues to exclude any benefit from xPloration or if the reiteration sort of includes expectations now that you're 1 quarter in with the launch.

Yes. I think as we said, we had indicated that xPloration would be additive to what we had. I mean this number that we have here in Q2, it's a great start to this, but it's pretty small numbers, but no change to the guidance, but this xPloration should be additive to that.

Yes. And still no change also, Micheal, to the -- we see xPloration as additive and accretive to the business, right, in terms of how it's designed to run. We've been preparing for this launch for quite a while, and we're excited about it. The feedback has been great.

And your next question comes from Matt Hewitt from Craig-Hallum Capital Group.

This is Jackson [indiscernible] on for Matt. Congrats on the quarter. Yes, I wanted to dive into xPloration there a little bit, seeing revenue flow through. Curious if you guys could provide a little color on the pipeline as to how that's going, maybe even if not numbers, help give some guidance on that.

Yes. Yes. Thanks, Jackson. We launched the Partner Access Program, obviously, in May, mid-May at the PEGS conference in Boston. That was really a perfect place to launch the technology given the attendees of that meeting. We were really happy with the reception we got. We were voted the Best of Show, which was cool. But a lot -- more importantly, a lot of really great dialogue kicked off there. We're now at 100 active partners, obviously, who are candidates, if you will, for xPloration, some -- for some of whom it's more relevant than others, obviously, just given business model. But we are really happy with the fact that we sold and deployed an instrument really within weeks of the launch at a global partner. And I think that bodes very well for how we're positioned. The book of business is filling up really nicely. We're managing a lot of business activity around it. These are obviously capital acquisitions. So the process is slightly different than a standard technology licensing process. But we are really pleased with the feedback we're getting and the momentum that the xPloration team is building up and for what the technology is doing for the business. I'll also note, too, that we are also getting interest from others who are not currently OmniAb partners who are sort of leading with xPloration, wanting to become discovery partners, specifically with xPloration in mind. And I think that really speaks to some of the comments I made earlier about this really being the right time for xPloration from a lot of different perspectives.

And your next question comes from Brendan Smith from TD Cowen.

Congrats on the quarter. This is Jackie on for Brendan. I was just curious what that time line looks like for existing partners that want to become a part of the Access Program? Is it kind of a blanket requirement to purchase an instrument? Or are you guys also offering a sort of data generation side separately for those partners?

Yes. Yes, good question, Jackie. Obviously, xPloration, I'll just kind of step back first and say xPloration has been a part of our workflows internally for many years, right? And that's kind of what I mean in terms of us preparing for xPloration launch and deployment for partners for a while. xPloration has also been a key part in how we leverage big data generation, our AI and ML tools that we've branded OmniDeep. And those are all things that we continue to do for our standard discovery partners, right? So -- and that also attracts partners not only the ability to get access to 4 species of animals and novel repertoires of fully human antibodies, but also those downstream workflow abilities that we've built up over time that allow us to provide them with a wealth of winners, if you will, from an antibody sequence perspective. So our partners still get access to that. They still get access to xPloration through us. That said, there are some partners who have their own wet labs and are interested and are doing the amount of work and the number of campaigns per year that it makes sense for them to have an xPloration instrument in-house. So the answer is really no change to how we interact with our partners in terms of data generation and sharing. But now certain partners obviously have the ability to buy an xPloration instrument. Kurt is going to add.

Yes. Let me add on, Jackie. So let's say somebody comes to us and they're interested in an xPloration instrument, and they're not currently a partner. So we will have that dialogue and say, we let them know that this is a Partner Access Program. And if they're interested in becoming a partner, then we would work out and do a license with them to give them access to our technology stack and it could kind of be done at the same time. They'll sign that license to become a partner, and then we could engage in the discussion on the sale of an xPloration unit. So that's how it would work.

That's awesome and super helpful. I appreciate the color. Maybe just -- obviously, you might not be able to say much about this, but any color on where you expect your second tech launch to land regarding maybe whether it's going to be kind of continuing more on this AI/ML data portfolio side or more towards the antibody legacy business?

Yes. Yes. Great question, Jackie. I will say we are planning an additional technology launch this year. We've generally launched our new technologies at major scientific conferences that are very relevant to our partner set, right? The technology we're going to launch is informed by, obviously, the deep relationships we have with our 100 partners and growing and also kind of leverages that vantage point that we have on the industry. So we'll talk more about it when we launch it. I'll just say we will launch it this year. It is certainly highly relevant to our strategic mission to help partners discover antibodies more quickly and efficiently. And we think it will actually be a pretty impactful one with a lot of novelty to it.

And your next question comes from Stephen Willey from Stifel.

Just with respect to the Janssen trispecific, the data does look quite interesting. Does that fall into the grandfathered prepaid license bucket? I guess I asked the question because I know that the prior bispecific that Janssen got approved, teclistamab, I believe, was also prepaid in nature.

Steve, good question. You're correct in that the disclosed economics around the Janssen deal. Actually, it wouldn't qualify as prepaid as you've described it here. There are actually $35 million of milestone payment associated with first sales. And that's the same path that was disclosed back when TECVAYLI was approved and launched in the U.S. and Europe. So there's payments associated at launch. So it wouldn't -- it's not a fully paid license.

Got it. Understood. And then I understand it still early in xPloration, and it's probably hard to give guidance around anything at this point. But just curious if you guys have a rough estimate that you might be willing to proffer up with respect to what the back-end stream of consumable and subscription revenue may look like on a per instrument basis. Is that a number that you guys would be willing to disclose? Or is there, I guess, kind of an industry reference that you would point us to?

Yes. It's a good question, Steve. I mean we have estimates of what we think those might be, but it actually varies depending on the customer that's using it. So I don't think we're ready to provide what those estimates are at this point, but it could be different depending on the type of customer that is using the instrument. So I don't know, Matt, anything to...

Yes, I think it's still -- yes, nothing really to add there other than it is still early days. But it's a high-margin business on the back end, which I think bodes very well for the xPloration line.

Okay. And then you talked about the Seismic molecule being the third OmniChicken-derived antibody into the clinic. Do we know just, I guess, roughly of what proportion of those assets that are preclinical and beyond? I guess it's -- those 61 assets are derived off of that platform as well. And does that technology tend to command a bit of a higher royalty rate relative to the average -- relative to the overall average of the portfolio that you provided?

Yes. Steve, obviously, a range of royalties as you look across our full portfolio, right? And as that mix has evolved, we're seeing improvement in the average royalty with evolution of the mix across the portfolio. Just sort of speaking generally about the chicken platform, as I said, we've had 3 now OmniChicken-derived antibodies enter the clinic, chicken generally has within it a number of technologies, our standard OmniChicken, which obviously is a chicken that produces fully human antibody sequences. We also have OmniClic, which is a chicken with a common light chain that also produces fully human sequences, really designed specifically around bispecifics. We launched OmnidAb not that long ago, about 1.5 years or so ago, which is a chicken that produces domain antibodies, which are really interesting in CNS and other areas. And then we continue to innovate around the chicken as well. It's a highly differentiated technology for a lot of reasons. In terms of the questions around the 61 programs that are post discovery stage or preclinical or later, there are definitely a number of chicken programs in there. In fact, we have an OmnidAb represented in there as well, which is a pretty quick progression for a newer technology. But we've not kind of broken it down by source technology at this point.

And your last question comes from Connor McNamara, RBC Capital Markets.

This is [ Carter ] on for Conor. Congratulations on the quarter. I just had a question about the business plan for xPloration. Is that mostly selling instruments and then also selling consumables? Or is that a reagent rental kind of plan that you want to do with the xPloration?

Yes. It is selling instruments. You're right, the way you described it, where we will sell instruments to partners. And then downstream of that, they will buy from us proprietary consumables as well as software license with maintenance as well. There are 2 primary consumables, which are chips and plates that are needed for runs of the instrument.

Perfect. Just congratulations with the new additions of programs and partners. As you look in your funnel with folks who are looking at the platform, what are some of the themes that you're seeing for the programs that your partners are exploring? Has it changed from oncology to CNS or infectious diseases? Or could you give just broad themes as to what you're seeing right now?

Yes. Great question. One of the things that we do think about when we innovate around new technologies is kind of not only where the industry is right now, but where the industry is headed. And I think now with 381 programs growing, over 100 partners continues to grow, we have a pretty interesting vantage point on the industry. And so we think about what technologies partners want. We also think about ways to diversify our platform and diversify our portfolio, I should say, from a therapy area or other use perspective. So we look into our preclinical assets, we see, of course, oncology, as you'd expect in the industry, but we also see inflammation, fibrosis, renal, dermatology, a growing subset of CNS diseases. We see some metabolic -- we see a lot of interesting trends in the discovery space as well as my perception is that as big pharma starts to take bigger swings at bigger areas, we see that in the types of targets they're going after. So it's a cool vantage point on the industry, but we're also seeing a lot of diversity there forming in our pipeline.

There are no further questions at this time. Mr. Matt Foehr, you may proceed.

Thank you all for joining our call today. We appreciate your interest and engagement with OmniAb. We look forward to discussing our third quarter financial results at our next conference call, which will be in early November. In the meantime, we're looking forward to participating in a number of investment conferences in the coming weeks and months, and we'll announce those details shortly. So thanks again, and have a nice afternoon.

Ladies and gentlemen, this concludes today's conference call. Thank you very much for your participation. You may now disconnect. Have a great day.