Good day, ladies and gentlemen, and welcome to the Pacific Biosciences of California, Inc., Second Quarter 2014 Earnings Conference Call. [Operator Instructions] As a reminder, today's conference is being recorded. I would now like to introduce your host for today's conference, Ms. Trevin Rard. Ma'am, you may begin.

Thank you. Good afternoon, and welcome to the Pacific Biosciences Second Quarter 2014 Conference Call. Earlier today, we issued a press release outlining the financial results we'll be discussing on today's call, a copy of which is available on the Investors section of our website at www.pacb.com, or alternatively, as furnished on the Form 8-K available on the Securities and Exchange Commission website at www.sec.gov. With me today are Mike Hunkapiller, our Chairman and Chief Executive Officer; Susan Barnes, our Chief Financial Officer; and Ben Gong, our Vice President of Finance and Treasurer. Before we begin, I'd like to remind you that on today's call, we'll be making forward-looking statements, including plans and expectations relating to our financial projections and products that are subject to assumptions, risks and uncertainties and may differ materially from actual results. These risks and uncertainties are more fully described in our Securities and Exchange Commission filings, including our most recently filed quarterly report on Form 10-Q. Pacific Biosciences undertakes no obligation to update forward-looking statements. In addition, please note that today's call is being recorded and will be available for audio replay on the Investors section of our website shortly after the call. Investors electing to use the audio replay are cautioned that forward-looking statements made on today's call may differ or change materially after the completion of the live call. And now let's turn the call over to Mike.

Thanks, Trevin. Good afternoon, and thank you for joining us today. We are pleased with the second quarter 2014 results and the progress we are making in driving our overall business. Highlights of our second quarter financial results are as follows: We delivered 8 systems during the quarter, and with over 100 systems in our installed base now, we are becoming a well-established player in the sequencing space. Instrument revenue for the second quarter was $4.7 million, up 73% from the prior Q2 estimate revenue of $2.7 million. Consumable revenue for the second quarter was $3.0 million, up 62% from the prior year Q2 consumable revenue of $1.9 million. This is being driven by strong utilization growth on an increasing installed base. We're now averaging over $120,000 in consumable revenue per year per installed system. Total revenue for the second quarter was $11.4 million, up 89% from $6 million in Q2 2013. Year-to-date, our revenues for the first half of 2014 are up 98% from our first half 2013 revenue. On that note, it is clear from a revenue trend that PacBio is continuing to gain commercial traction. Our bookings in Q2 of 5 units were lower than the number in the previous quarter due to some customer logistical and tender delays that can cause our quarterly orders to fluctuate, but our pipeline continues to grow. With our installed base growing and system utilization increasing, our business has never been in better shape. We continue to forecast 70% growth in our revenue this year compared to 2013. Now I would like to provide some highlights from industry conferences we attended since our previous earnings call. At this year's American Society of Microbiology meeting in Boston, there was a very interesting presentation by Dr. Julie Segre from the National Human Genome…

Thank you, Mike. And good afternoon, everyone. I will begin my remarks today with a financial overview of our second quarter that ended June 30, 2014. I will then provide details on our operating results for both the quarter and year-to-date with a comparison to the second quarter of 2013 and year-to-date comparison to the first half of 2013, respectively. I will conclude my remarks with a brief discussion of our balance sheet. Starting with our second quarter and year-to-date financial highlights. During the second quarter, we recognized revenue of $11.4 million, and incurred a net loss of $19.1 million. This brings our year-to-date total revenue to $23.1 million and our net loss to $38 million. We ended the quarter with $105 million in cash and investments, $13.7 million lower than the $118.7 million reported at the end of Q1, and $7.5 million lower than the 2013 year-end balance of $112.5 million. As a reminder, in the first quarter this year, we raised $20.6 million in equity funding from our aftermarket facility. We did not issue any equity under this ATM during the second quarter. Excluding these proceeds, cash use totaled $28.1 million year-to-date. Turning to revenue. Revenue increased substantially in Q2 year-over-year across all products and services. Total revenue for the quarter of $11.4 million was 89% greater than the $6 million recognized in Q2 of 2013. Year-to-date revenue in 2014 was $23.1 million, up 98% over revenue of $11.6 million recognized in the first half of 2013. Instrument revenue increased 30 -- 73% to $4.7 million in Q2 2014, from $2.7 million during the same period last year. Year-to-date, instrument revenue increased 117% to $10 million in 2014 versus $4.6 million for the first half of 2013. The increase in revenue reflects 8 instruments recognized during the second…

Thank you, Susan. I will be providing an update to our 2014 financial forecast. Starting with revenue, we are pleased with the continued growth we saw in Q2, and we are maintaining our forecast of 70% growth in revenue for the year. This translates to a total annual revenue estimate of $47 million to $48 million for 2014. With regard to the third quarter, we had 10 instruments in backlog at the end of Q2, and we expect to deliver a majority of those systems in Q3. Moving on to gross margin, as we have seen in the past 3 quarters, $1.7 million quarterly amortization of the Roche payment from last September continues to result in favorable year-over-year gross margin comparisons. Our gross margin at 27% for the second quarter was in line with our expectations, and our forecast for the year remains similar to what we communicated last quarter with a slightly tighter range. We are forecasting our gross margins to be between 25% and 27% for the year. As a continuing reminder, at our current revenue levels, small changes in gross profit dollars can cause fluctuations in our quarterly gross margin percentage. Our operating expense for Q2 at $21.4 million was a little higher than the previous few quarters due to slightly higher research and development expenses. We plan on maintaining our quarterly operating expense at around this level for the rest of the year. Our operating expenses include noncash stock compensation expense and depreciation expense that together amounts to between $3 million and $4 million per quarter. Net interest expense of $800,000 for the second quarter was a little higher than our previous estimate due to a revaluation of the noncash derivative component of our debt. Excluding the revaluation, which amounted to $150,000, our net interest expense was in line with our previous estimate. We expect to continue to record approximately $650,000 in net interest expense per quarter this year. With regard to cash use. $14 million this past quarter and $28 million year-to-date, excluding ATM proceeds, puts us right on target to meet or beat our previous forecast of $60 million for the year. Taking into account the $21 million in additional cash we raised in Q1 from the ATM, we expect to use less than $40 million for the year. Therefore, we should end the year with at least $73 million in cash and investments. Now with that, we'll open the call to your questions.

[Operator Instructions] And our first question comes from the line of Bryan Brokmeier of Maxim group.

You started off talking about the bookings and the decline sequentially. I was wondering if you could provide us a little bit more color. And also, in terms of the different conferences that you mentioned that you attended during the quarter, were any of those bigger drivers of sort of your pipeline for future bookings? And what sort of research those customers are doing within your pipeline?

Okay, if I could fill a lot of that. The issue with orders was driven by a few cases, as we tried to point out, of sort of customer logistical and tender delays, which took longer for them to get through the process than we and they would have hoped. So we see that as, hopefully, a picker [ph] blip in that. It wasn't a lack of order prospects in our pipeline at all. That actually has continued to increase. But given that -- and we tried to emphasize this before, we're still a relatively small total order number per quarter, and a couple of those sites having a logistical issue, either because their tender process is slow or because they're having to wait on some other event, a lab being secured and so forth, can cause quarter-to-quarter blips in that. But it didn't concern us greatly. Relative to the conferences, I think we certainly saw a really healthy interest in the HLA community. This was really the first time that we had, had much of a public presence at an international conference at this level in the immunogenetics space. It was the first time that our early customers at 2 of the largest typing centers in the world had, had a chance to present their experience with the PacBio RS II system. We even had some relatively bluebird presentations by some of our other customers in the academic world who were doing substantial HLA typing that we didn't know about, really, until the presentation, till the conference. So we had a lot of interest from a lot of different kinds of laboratories interested in the whole HLA space, not just in the major typing centers, but in a lot of the other labs that may be engaged with pharmaceutical companies, who are very interested in having high-resolution HLA typing in done conjunction with clinical trials and other large genomic projects. So I think we rated that conference as a real success from a prospect perspective. In the Asia conference, I think it was a continuation of the interest we're seeing within the plant and animal world to kind of reengage with genomic sequencing in order to come up with much better reference genomes for a whole variety of organisms than they've been able to successfully generate with the combination of short-read and all-Sanger methodologies, which are both slow and expensive but also just don't give you the kind of results that they really want and need within that space. But I think we saw both of those conferences as very successful marketing opportunities for us.

Have you seen some of those opportunities in your pipeline turn into bookings since the end of the quarter?

Well, we're not talking about the results for this quarter, but we certainly have seen a fair interest of those turning into sort of proof-of-principal type runs with people particularly in the relatively new -- and the HLA space. Within the plant and animal ones, we have an ongoing buildup on our pipeline there.

Then, just the last question...

[indiscernible] across the world.

Okay. And just lastly, on your Roche collaboration. You said you expect to achieve the first milestone later this year. Any more color on what that milestone is? Is it completing an instrument? Or any details about what you've accomplished so far?

No. What we said and what Roche has said publicly from the beginning, is that we assume that getting a diagnostic level device created would be at least a 3-year project, and we set out with them at the beginning a series of milestones as part of that development process, but we've been unwilling, for competitive reasons, to go through the details of what those milestones were going to be and what the specifications associated with that system were, and I think we're going to stick with that.

And our next question comes from the line of Bill Quirk of Piper Jaffray.

First question from me is just, I want to talk a little bit about consumables. Consumers bounced around a little bit up in the fourth, kind of off a little bit in the first and then back up here in the second. And so, just trying to get a little better sense, I guess from your perspective, kind of how do you see this bouncing around? Obviously, it's moving generally in the right direction. Are we at a level now where we consider this to be sustainable with upside to come? Just help us think a little bit about this.

Well, it's like anything else, they bounce around a little bit. We're still a relatively small total number so that a few big orders can change 1 quarter. I mean, some people will order on a 6-month basis, some on a 6-day basis. So it does matter when you get big orders in chunks. I would say that we're quite happy with the overall increase. And If you kind of step back and look at it, it tends to -- in some cases, it's gone up and, then it's leveled off 1 quarter, and it's gone back up. Draw a line through more than 2 data points, you get a pretty good trend, I think. And that's kind of where we're gauging our ability to forecast that. [indiscernible] uptick this year and sort of across the world, I think, and we're seeing, as we kind of pointed out, an increase in per customer usage. I think the last guidance we'd given you was somewhere between 100 to 120. And we're now saying it's north of 120, on average, for the year.

And Mike, just kind of going back to the earlier question around bookings, there wasn't any effect from any of that competitive dynamics in the market. Your still -- your funnel, your sales funnel, seems to be in pretty good shape. Is that the message you're trying to tell us? No issues around competition?

Well, I wouldn't say there's no issues around competition, but I don't think that was a substantial issue for us in the quarter. I mean, we compete in a select set of applications in the marketplace very well. We're not a head-to-head competitor with any of the short-read technologies, either Illumina or Ion Torrent, for most things. We tend to focus on those areas and our customers do, where those technologies don't perform so well at this point. So that's where we go. And I don't think the competitive landscape in that space has really changed very much.

Okay. Great. And then just lastly for me. You typically highlighted on the call but just any update with respect on the planned system upgrades?

Upgrades, yes, so we do plan on putting out more system enhancements during the course of this year, not hardware ones, but we actually kind of lined this out in our investor presentation earlier where at least a couple of times a year, we put out software enhancements and we put one out, I think around April this year, so we're kind of on schedule to do another one in the latter part of this year. And we also typically put out some sort of chemistry enhancement, and we're also on target to put one of those out later on this year. We haven't given specifics as to what the improvements are going to be on those -- from that release, but it's not too far in the future. So you should keep an eye out for that.

Yes, what we have talked about is, generally, that they will represent an increase in average read length and throughput, improvements in sample prep that you have, again, high utilization of the system. And we will be rolling out, actually, a series of those in the last half of the year.

And our next question comes from the line of Amanda Murphy of William Blair.

It's actually J.P. in for Amanda. I just had a couple of questions around consumables usage. Do you guys see kind of a large chunk of customers running at full capacity and maybe others not so much? And then can you just remind what me what the theoretical max pull through per just one machine is?

I'll take a first shot at that. So it's not an 80-20, meaning, it's not so concentrated that 20% of our customers are doing 80% of the consumables. It's actually more spread out than that. I think with any capital, you might expect that there's going to be some customers that are not as productive as others. We certainly have that. But I'd have to say that the overall usage is spread across a large number of users. And to answer the question on the high end, we definitely see multiple customers who've been able to do a run rate of over $300,000 per year. So we think there's adequate run rate in terms of that increase and average pull-through. As Mike said, it's not greater than $120,000, but that means there's still a lot of capacity left out there for improvement.

And then just one more. Can you provide additional detail on the size of the HLA market? I mean, have you guys looked at kind of a total addressable market there?

Well, yes, but it's -- let me give a caveat at the end of that. So I think the general estimates are that the available market in petitional HLA registry typing market is in the order of $200 million to $300 million a year worldwide. However, I think that the larger potential market there is actually not in a traditional registry type work but in association with clinical trials, being able to do HLA typing at high resolution for big trial projects. And we've seen a fair amount of interest from the pharmaceutical world as have several of the labs that traditionally do typing for registry purposes. There, as soon as the technology is appropriate to handle that high resolution, high throughput requirement that they have. And that's potentially from my perspective, maybe several times bigger than the traditional market, which is not trivial for us. I think it's been untapped because just the technology has not been there.

And then, are you guys able to provide a -- kind of a bookings outlook for the remainder of the year? Like, should we think about the logistical delays as just pushing into the next quarter? Or is it just going to push things down the line in general?

Yes, J.P., the -- we have not traditionally given a specific on bookings outlook, but the -- embedded in our revenue outlook of 70% growth, it suggests that there's going to be higher bookings than what we just saw in the second quarter because in order to achieve those revenues, we, obviously, need to have systems to install. And even with the growth we have in consumables, we'd probably need to continue to see some pretty healthy bookings in order to get to the 70% revenue growth. But that's on purpose that we've maintained that revenue forecast.

[Operator Instructions] And our next question comes from the line of Tycho Peterson of JPMorgan. Tejas Savant - JP Morgan Chase & Co, Research Division: It's Tejas on for Tycho. Can you share some color on the backlog in terms of new versus existing customers?

Yes, so the backlog of the 10 systems, we definitely have, in that backlog, additional systems for existing customers. And in fact, one of the bookings we did have this past quarter was also for an existing customer. So related to a previous question about utilization, when people get to a certain utilization, they do look at buying additional systems and then we had mentioned before that we've had multiple orders in the past and, usually, it takes a little bit of a while to get everybody installed on those multiple orders. Tejas Savant - JP Morgan Chase & Co, Research Division: And then, you guys have highlighted the ag opportunity and sequencing cash crops. Has that translated into any orders yet? Or is it still too early for that?

Yes, several of our existing customers are doing that. And in Europe, as an example, KeyGene is one of the premier sort of genomics/agricultural companies. They're one of our highest-capacity users on our systems as an example. But a lot of -- we have a system at the USDA, which is focused on plant...

Or labs.

And animal ones. A lot of the core labs do projects that are in that. Several of the service providers and our Asia customers are doing large plant and animal, mostly plant genome. So that's already a good part of our business. And as people get out the results of some of the bigger projects they've done in comparison to their other attempts with other technologies with shorter read capacity, then that's making a lot more people aware of the advantages of the PacBio platform. Tejas Savant - JP Morgan Chase & Co, Research Division: Okay. And now just quickly turning to Roche. Does your guidance for this year of $47 million to $48 million include the milestone payment? Or will that be separate?

That's separate. So the $47 million to $48 million is based off of just the same kind of revenues that are in the revenues today from Q1, Q2. Tejas Savant - JP Morgan Chase & Co, Research Division: Okay. And in terms of...

[indiscernible] what the size of that payment might be, either. Tejas Savant - JP Morgan Chase & Co, Research Division: All right. Any thoughts on their acquisition of Genia in terms of the nanopore sequencing effort announced in Roche and how that changes things for you, if it does at all?

I think we commented on that before. From my perspective, it doesn't -- and from what we understand from Roche, it doesn't change our relationship with Roche at all. They view this as another long-term opportunity for them to potentially come up with a technology that they could sell in more areas than the diagnostic arena, which is where our agreement with them is limited to. But they also recognize it's a very, very early technology with a high risk associated with it. So to them, it's another bed in the space, but one that they realize is fairly far from commercializable.

And our next question comes from the line of Zarak Khurshid of Wedbush Securities.

Zarak Khurshid at Wedbush. Can you tell us what the gross margins are on the consumables, currently? And taking it a step further, what revenue run rate is required for you to break into the kind of 50% gross margin range?

Zarak, this is Ben. We don't give the breakout of the gross margins, but we do let people know that from a mix perspective, the consumable margins are definitely higher than they are for the systems and the service. And sometimes you're subject to just the overall revenue being not high enough to cover amount of fixed costs. So I think your question has more to do with at what revenue levels can you get to perhaps breakeven. And what we've said in the past is somewhere between $100 million and $150 million in revenues on the top line, you'll probably get to breakeven. And from that, you could probably start to think about what margin that means to cover all the operating expenses.

And I'm showing no further questions at this time. I would now like to turn the call back over to Mr. Mike Hunkapiller for any closing remarks.

Okay. So in closing, we remain steadfast in our commitment to bringing the unique advantages of our SMRT technology and products to our customers and the scientific community in general. We believe that SMRT sequencing provides the industry's most complete and accurate picture of genomes due to its superior performance in sequencing accuracy, uniformity of coverage, extremely long read lengths and the ability to characterize DNA-based modifications. We continue to make progress in driving the adoption of our products and is rewarding to see momentum building in our business. We look forward to talking again in 3 months time.