Christian Henry
Management
I mean, weâll have to see how the world unfolds, but I believe very strongly that it wonât. And the reason is today, not only is the price per genome, significantly different on our platform versus a short read platform, but also the throughput is a lot lower than, what you can do on a short read platform. So really itâs a combination of not just the pricing, but the throughput and, as we narrow the gap on both, I do think you see accelerated adoption because one, you can do the large projects using long read. Two, everyone is seeing now we talked about the Pangenome, the HPRC in my written remarks, the reality is that the reference genome now is changing such that, it will demonstrate that short reads are insufficient for whole genome sequencing. They just are. And I think that as we get the economics and throughput improve, it will completely change the paradigm. And on top of that, if we can continue to deliver epigenetic information telomere-to-telomere sequencing, with SNVs and Indels and all the structural variation at very highly accurate levels, why you would have to do multiple assays, which in the, even if the short read sequencer was charging a $100, letâs say for their sequence, youâd still have to run another sample prep to get, to get the epigenetic data, for example. And Iâll just it, the second you do that, youâre actually more expensive than what weâre talking about here is we kind of break through the $1000 genome barrier. And so for us, Iâm very encouraged about the progress weâre making in R&D, about the state of the market and the state of the market being the proof points of why long reads matter. One of the core strategies that I had coming into the company was to, do enough collaborations, so that everyone could see the power of HiFi sequencing and the power of long reads versus short reads. I think all of those proof statements are becoming overwhelming, quite frankly. And now it comes, itâs incumbent for us to get the products to market that will enable, enable the scale and the economics that will, make a dent in that short read market, sort to speak.