Hello, and welcome to the Quantum-Si Q3 2021 Earnings Call. My name is Boben [ph] and I will be coordinating your call today. [Operator Instructions] I will now hand you over to your host, Juan Avendano, from Quantum-Si Investor Relations. Juan, please go ahead.

Hello and thank you for joining us today. Yesterday, after market close, Quantum-Si released financial results for the third quarter ended September 30, 2021, and provided a business update. The release is available on the Investors section of the company's website. Joining me today are Quantum-Si's Chief Executive Officer, John Stark; and Chief Financial Officer, Claudia Drayton. During today's call, we will be making certain forward-looking statements within the meaning of Federal Securities laws. These statements involve material risks and uncertainties that could cause actual results or events to materially differ from those anticipated. Additional information regarding these risks and uncertainties appears in the section entitled forward-looking statements of the earnings press release. For more complete risk and description of risk factors please see the company’s filings made with the Securities and Exchange Commission. The company disclaims any obligation to update any forward-looking statements. During this call will discuss certain financial measures that are not prepared in accordance with U.S. Generally Accepted Accounting Principles or GAAP. reconciliations of non-GAAP financial measures to the most directly comparable GAAP financial measures are included in the earnings press release. As a reminder, this call is being webcast live and recorded. A replay of the event will be available on the company's website following the call. I would now like to turn the call over to John.

Thank you, Juan. And good morning, everyone. Thank you for joining Quantum-Si’s third quarter earnings call. The team and I are very pleased by the progress we are making on execution across all aspects of the company as we continue to expand customer access to our platinum system, key institutions representing high growth segments within the proteomics market. Claudia and I look forward to discussing our third quarter performance, which marks our second time reporting results in first full quarter as a public company. We will begin with prepared remarks detailing our third quarter performance and progress related to the foundational goals we laid out in our last earning call and then we will open for questions. During the quarter, we have continued to build momentum and deliver on our mission of transforming the field of single molecule analysis in proteomics. We are the first company to commercialize a system that enables digital sequencing at amino acid resolution through our differentiated Time Domain Sequencing protection method. As we discussed on our previous call, single molecule protein sequencing expands the resolution of the proteom by providing visibility into protein variants and measuring specific changes at the individual amino acid level. Other established and emerging technologies with the measure or confirm the existence of the 20,000 known protein. Our technology, however, has the ability to sequence the entire structure at each individual peptide chain making up the backbone of a protein to provide insight into the estimated millions of structural forms that exist in the cell. These modified structures potentially represent key biomarkers that will be foundational for the future development of therapies and how we detect disease. In parallel, we are commercializing a streamline end-to-end bench top system that simplifies the workflow, enabling ease of use and better access to the…

Thank you, John. Hello everyone. Let's discuss now the details of our Q3 financial performance, including a high-level spending outlook for the next few quarters. Total operating expenses in the third quarter of 2021 were $25.2 million, an increase of $16.6 million from $8.6 million in the third quarter of 2020. Operating expenses decreased sequentially in Q3 from Q2 levels. Recall that in Q2, we recorded one-time transaction expenses related to our merger with HighCape. Research and development expenses for the third quarter of 2021 were $11.1 million compared to $6.7 million in Q3 of 2020. As John mentioned earlier, we are continuing to hire employees in all areas including R&D. In addition, our spending also reflects important investments we're making with our suppliers. Sales and marketing expenses were $1.1 million for the quarter, compared to $0.3 million in the third quarter of last year, while general and administrative expenses for the third quarter of 2021 were $13 million compared to $1.6 million in the same period last year. The increase in expenses is driven by higher headcount as we continue to build our team and extend this related to being a publicly traded company. Net loss for the quarter was $18.1 million compared to a net loss of $8.6 million during the same timeframe in 2020. Adjusted EBITDA was a loss of $17.5 million in the third quarter of 2021, compared with a loss of $7.8 million in Q3 of 2020. We have provided tables to reconcile adjusted EBITDA to GAAP net loss in the earliest press release. We had $500.2 million in cash, cash equivalent in marketable securities as of September 30, 2021. We have a strong cash position that allows us to continue investing in our business and to prepare for commercialization. In the next few quarters, we expect to continue investing in hiring personnel. Hires will be mainly in R&D and sales and marketing as we continue to advance our technology and to scale for our anticipated full commercial launch in 2022. Accordingly, we expect operational spending to continue to grow sequentially in the next few quarters. In summary, in as John highlighted in his prepared remarks, our early access program is off to a strong start as reflected by the higher-than-expected number of partnerships we have executed so far. We are also encouraged by our progress in ramping up operations and proactively executing supply chain initiatives to support our manufacturing and commercial readiness. As a result, we reiterate our key milestones in long-term financial targets. We anticipate commercial launch of our system in 2022 and expect a combined carbon and platinum installed base of over 5,000 instruments by 2025, with an average selling price of about $50,000 and annual consumables pull-through of over $45,000 per unit in a long-term gross margin target of over 70%. With that, I will now like to turn the call back over to John for closing remarks. John?

In Q3, we made significant progress on our core foundational goals and accelerate all phases of commercial efforts. We are encouraged by the enthusiasm within the scientific community as we move from known protein confirmation to resolution at variant and structural level. In our view, this is what reflects true biological activity within the cell, and what can eventually be leveraged by the clinical community to advance how to detect and treat disease at earlier stages of progression. We are well-capitalized to fulfill our mission with over $500 million on the current balance sheet and are ready-to-compete for market leadership in the field of single molecule protein sequencing in proteomic analysis. Thank you for your time today, and I will now turn the call over for questions.

Thank you. It is now time for Q&A. Our first question comes from Kyle Mikson from Canaccord Genuity. Please Kyle, go ahead.

Thanks. Hi, John and Claudia. Hope you guys are doing well? Congrats on the progress so far, really sound encouraging especially the kind of the targets there, I think, you kind of neat over the long-term. I do just want to ask those since we're approaching the year end. If you could just tell us if the 500 plus system placement number you previously laid out for next year is still the right way to think about the near-term forecast. I know you shored up the inventory sounds honestly on that front, but just given some of these shifts supply shortages will that affect station needs to be reduced? Thanks.

Hey Kyle. Good to hear from you. Thank you for joining the call. Just to confirm the 500 platinum systems we have gone in process in placing that order and we're starting to receive instruments as we speak. So that would more than fulfill the 2022 revenue mark for platinum. And as far as chips, I think we addressed that during the call. Strong relationships with our foundries not only current supply, but development of future chips and obviously with the acquisition of Majelac really gives us control now over the packaging, as well as supply to our customers. So, we're feeling very good about where we're at this point.

Perfect. Thanks for that. And obviously demonstrating reproducibility is obviously a critical end point for this early access program. From what you've seen during the program with ESPCI et cetera, are you tracking in line with their expectations for this early launch? And I guess what challenges have you seen so far and what – like issues of users faced in the early stages?

Yes. No, another great question. So, first of all, reproducibility is one of the key aspects, actually take a step back. Really the first focus especially going out to 10 is to make sure that we cannot only deliver install and train 10 sites and that'll all be accomplished at least by the end of the year, if not by the end of this month for those 10 sites. As far as reproducibility, we're very thankful for these sites. I'd actually be confirming data that we have generated internally just to show equivalent. So that has gone very, very well so far. As far as are concerned, I mean, what we're facing now in early access programs and why you do them is because now we're looking at specific applications, right? We mentioned quite a few during the press release and during the narrative that we just gave where customers are looking to barcode single cells, right? Not only for interrogation of proteins derived directly from a B-cell, but also in OHS, Oregon Health Science Centers case, they are looking at neurological tissue. So, one of the things is that where did these customers to actually optimize that approach. Those are some of the challenges and make sure we can specifically interrogate the proteins of interest.

Got it. And as you kind of worked through this, this program and you see the data you being generated. I am just curious what improvements you want to make the Platinum, and I guess Carbon too, before you launch. I'm thinking like, what needs to be locked down really assay throughput increasing the number of immune acids you want to detect, that'd be helpful to hear it. And I guess just related to this, how many individuals for the commercial team or the salesforce are you targeting, heading into the launch?

Yes. Sure. So multiple questions there. So, let's start with the last one as far as commercial team. So right now, we've been able to build up the marketing team, which is very focused on voice of customer, as well as application. Obviously, it started hiring specialists that are going to be targeting pharma or the clinically oriented applications. That's also going to be bringing forward some of the field application specialist. And we'll build that team in the first half of the year and that will be projected in our budgets. And your first question you asked before that?

Basically, the improvements to the platform before you launch one needs to be kind of locked down still?

Yes. It really encouraged Kyle, the performance of the Platinum system and the workflow thus far. I mean, I can't say that we were 100% confident that we'd be able to bring sites up in a month. But we've effectively been able to do that in train. So that gives us a lot of confidence in our ability to scale. And that's why we moved forward with the 500-instrument order from our contract manufacturer going forward into next year.

Perfect. And just move on to biopharma, obviously a powered user of the main proteomics technology is certainly going to be an important partner for you early on. Just wondering if you could talk about your progress at biopharma so far, just wondering if you are confident in some of those companies will be early adopters, and you could kind of give us any feedback thus far from the end market, they'd be really helpful as well.

Yes. And first, I already confirmed that biopharma in industrial accounts will be part of the early access program. Unfortunately, we don't have the rights to disclose them and typically when you're working with pharma in later stage, say biomarker development, implementation and the clinical research stages, a lot of times that information is kept confidential, but I can confirm that we're already working with them. There's a number of assays that we are considering at this point in time specifically focusing on content that could be used for inclusion, exclusion trial criteria. One example that we gave is post-translational modification, right? There's about believe right now, there's about four key thoughts relation events that occur at the amino acid level that could predict 80% of reoccurrence of lung cancer. This is a high interest to pharma and just a simple assay; with just four markers the reason we can do that so effectively is because we are looking at single molecule resolution and able to detect that at the individual peptides and amino acid level. And that gives you absolute frequency. So, these are assays that we're going to be working on in partnership with pharma, we will be doing the internal work ourselves.

Okay. Related to that, have you confirmed her ability to kind of elucidate those PTMs or are you still kind of working on that?

We've shown data in the past where we've been able to demonstrate being able to pick up phosphorylation. I believe some data was disclosed here a few months ago, showing tyrosine – by tyrosine event and then phosphorylated tyrosine event, but that is a dedicated program that we have, right now how about the San Diego.

Okay. Yes. No, that sounds good. Let me just ask one more before I hop off about Protein Evolution. I just wanted to ask if you could kind of walk through the decision to collaborate rather than I guess, merger acquire Protein Evolution. Just given the fact that PEI is a 4Catalyzer company and just reminded of the merger between high-profile and Liminal, which I still believe it's pending. Generally, there seems to be some solid synergies between you guys and proteomic solutions. So just wondering if you can kind of walk through why you're so excited and also, and John, I think this is kind of an important question if it's going to – if these reagents will be kind of integrated into carbon.

Yes. Great question again. And first of all, the team at Quantum-Si, we have a strong Protein Evolution team, right? Developing recognizers and cutters for our core programs in protein sequencing. What PEI actually brings to the table is expertise I'm working with infinity reagents, which is not something that we're developing necessarily internally. So, it allows us to really scale our plans as we go out for that expansion of the ecosystem, while the internal team can still focus on the core technologies and the core platforms; so that's how we see it.

Okay. Will it be integrated into carbon or standalone basically?

We have the opportunity for both. We can use affinity reagents, and again we're not disclosing the actual exact structure, but it can be used for targeted protein assays, which can be incorporated in the carbon, or we can use them for the future development of recognizers.

Got it. Okay. Awesome. Well, thanks so much.

Kyle, one thing I do want to stay on that too is there obviously PEI's collaboration that we're very excited about. We obviously have other opportunities to develop out content as well as recognize our development. So, there are other partnerships that we haven't announced at this stage.

Perfect. Sounds promising. Well, congrats guys. Thanks again.

Thanks Kyle.

Thank you, Kyle. [Operator Instructions] Thank you. This concludes our Q&A session. Thank you for joining today's call. I will now pass you back to Juan for closing comments. Thank you.

Well, thank you all for listening on your participation today. We look forward to updating you on our progress in the next quarterly earnings call. Have a good day.

Thank you everyone. You may now disconnect your lines.