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Transcript
OP
Operator
Operator
Ladies and gentlemen, thank you for joining us and welcome to the Q4 2025 Revvity Earnings Conference Call. After today's prepared remarks, we will host a question and answer session. If you would like to ask a question, please raise your hand. If you have dialed into today's call, please press 9 to raise your hand and 6 to unmute. I will now hand the conference over to Stephen Barr Willoughby, SVP, Investor Relations. Steve, please go ahead.
SW
Stephen Barr Willoughby
Management
Thank you, operator. Good morning, everyone, and welcome to Revvity's fourth quarter 2025 Earnings Conference Call. On the call with me today are Prahlad Singh, our President and Chief Executive Officer, and Maxwell Krakowiak, our Senior Vice President and Chief Financial Officer. I would like to remind you of the Safe Harbor statements in our press release issued earlier this morning and those in our SEC filings. Statements or comments made on this call may be forward-looking statements which may include but may not be limited to financial projections or other statements of the company's plans, objectives, expectations, or intentions. The company's actual results may differ significantly from those projected or suggested due to a variety of factors which are discussed in detail in our SEC filings. Any forward-looking statements made today represent our views as of today. We disclaim any obligation to update these forward-looking statements in the future, even if our estimates change. So you should not rely on any of today's statements as representing our views as of any day after today. During this call, we will be referring to certain non-GAAP financial measures. A reconciliation of the measures we plan to use during this call to the most directly comparable GAAP measures is available as an attachment to our earnings press release. I'll now turn it over to our President and Chief Executive Officer, Prahlad Singh. Prahlad?
PS
Prahlad Singh
Management
Thank you, Steve, and good morning, everyone. I'm glad you are able to join us to discuss our fourth quarter results and our initial outlook for 2026. Overall, 2025 proved to be a dynamic year filled with both new challenges and significant opportunities for both our company and our customers. I'm pleased to share that in spite of the evolving circumstances we faced, we closed the year on a high note. With our fourth quarter revenue, organic growth, and adjusted EPS all surpassing our expectations. This strong fourth quarter performance enabled us to exceed our adjusted EPS guidance for the entire year. It's especially impressive that even with factors such as changes in NIH funding, evolving tariffs, pharma policy uncertainty, the extended US government shutdown, foreign exchange movements, and shifts in DRG-related volumes affecting our diagnostics business in China, we were still able to deliver $5.06 in adjusted EPS, surpassing the initial guidance we provided a year ago. Additionally, our 3% organic growth for the year was also within our original guidance range we outlined last January despite all the unexpected challenges we encountered throughout the year. Our ability to achieve our initial organic growth guidance and exceed our EPS guidance in spite of these hurdles speaks to Revvity's resilience, our agility, and our overall ability to execute in those areas that are more fully within our control. We were able to accomplish all of this while still delivering strong outcomes for our customers, our employees, and our shareholders. In the fourth quarter, we saw positive momentum continue across our diagnostic businesses, with both reproductive health and immunodiagnostics performing better than anticipated. This strength led to our diagnostics segment organic growth being up 7% in the quarter overall. In our life sciences segment, we also continued to see trends gradually…
MK
Maxwell Krakowiak
Management
Thanks, Prahlad, and good morning, everyone. As Prahlad highlighted, we navigated and overcame many obstacles during 2025, and were able to finish the year on a strong note in the fourth quarter as both our organic growth and adjusted earnings per share came in better than we expected. With this stronger finish, we were also able to take the opportunity to further reinvest back into our people with our expectations overall while keeping our adjusted operating margins consistent. I am proud of what we were able to accomplish last year, as we were able to achieve both our organic growth and adjusted EPS expectations that were either in line to above our guidance coming into the year despite significant headwinds versus our initial assumptions. From an innovation perspective, we introduced several very exciting new offerings and collaborations during the quarter, particularly in the areas of software and AI, and we remain opportunistically disciplined with our capital deployment by announcing the acquisition of the software firm ACD Labs, which closed a few weeks ago as well as by repurchasing another $108 million of our shares. As we continue to remain extremely confident in the medium and longer-term potential of Revvity, we use this opportunity to dramatically reduce our share count. I think this will bode extremely well for our shareholders once end markets more fully normalize and our overall financial performance moves back towards our long-range plan in the upcoming years. Our ability to opportunistically deploy capital like we have is a direct result of our strong free cash flow generation and conversion over the last several years since becoming Revvity combined with our strong balance sheet, both of which I expect to continue. As we look to the future, we will continue to take a balanced and disciplined approach to…
OP
Operator
Operator
We will now begin the question and answer session. Please limit yourself to one question and one follow-up. If you would like to ask a question, please raise your hand now. If you have dialed in to today's call, please press 9 to raise your hand and 6 to unmute. Please stand by while we compile the Q&A roster.
DB
Dan Brennan
Analyst
Your line is open. Please go ahead.
DB
Dan Brennan
Analyst
Great. Thank you. Thanks for the questions. Congrats on the quarter. Prahlad and Max, maybe just on the 2% to 3% organic guide. I know you started talking about it back, I think, early September. And this was, you know, prior to the first MFN deal meeting struck by Pfizer. I think we've had 13 other signs since then. So there are definitely signs, you know, the biotech market's improving well. So just I know you've talked about it throughout this call about the arguable conservative nature to start here and you're leaving room for upside. But nonetheless, given you had that anchored back then and things haven't improved, I'm just wondering if you could provide more color on this two to 3% framework and kind of what the potential upside could be as the year unfolds.
MK
Maxwell Krakowiak
Management
Yeah. Thanks, Dan. So I think as we think about our 2026 guidance, you know, to your point, it is consistent with the framework that we provided back in September. And, yes, there have been some positive signs in our end markets since September. You know, therefore, I think as we look at the guidance for 2026, we do believe that there are multiple paths to potential upside across both revenue and EPS. You look at things from a revenue organic growth perspective, some of those paths starting first in the life sciences side. So one, you know, we aren't really modeling any improvement in the preclinical markets across both pharma, biotech, and academic and government. I think we continue to see positive trends in pharma biotech, whether that's around the MFN deals and the certainty that brings our customers, the biotech funding environment, the M&A environment. There's definitely been some positive indicators over the past couple months. And, look, it's tough to believe that academic and government is going to be as challenged as it was last year. The second thing, you know, from a software perspective, we have, you know, the launch of some new products, at the '25, early '26. We are not embedding any material benefit from those software launches in 2026. But, obviously, there's a potential that those could accelerate quicker. I think when you look at things from a diagnostic side, you know, on the newborn screening side in particular, you know, we're assuming more LRP type performance for that business as opposed to the outperformance that it's driven over the past couple years. You know, there's nothing fundamentally changing there other than just a more prudent assumption to start off the year. And then secondly, from an immunodiagnostic side, you know, we are…
DB
Dan Brennan
Analyst
Great. And then maybe just as a follow-up, just on the life science side, is it really just preclinical spending recovering that's gonna drive the strength in instruments and reagents? Are there any share potential there? And what can we be watching to get ahead of, like, when those businesses could start to turn up? Thank you.
MK
Maxwell Krakowiak
Management
Yeah. Look. So I think from a preclinical perspective, you know, I think it one, a big part of that is just continued momentum in the end market. I talked about some of the positive signs we're seeing there, and so really just a continuation of the demand development off those positive indicators. You know, in terms of your comment on share, I would argue we've been taking share over the past couple years continuously in the preclinical market, particularly within the reagents business. And so I think that's something that we look to continue to execute upon.
OP
Operator
Operator
Your next question comes from the line of Daniel Anthony Arias with Stifel. Your line is open. Please go ahead. Dan, a reminder to kindly unmute yourself by pressing star 6.
DA
Daniel Anthony Arias
Analyst · Stifel. Your line is open. Please go ahead. Dan, a reminder to kindly unmute yourself by pressing star 6.
Okay. There we go. Sorry about that. Max, on software, to your point, you have a handful of new products that you're launching here. Can you just sort of refresh us on the timing of coming to market and then what your uptake trajectory might be? I mean, it doesn't sound like you have much baked in for this year. But what should we think about the curve looking like? And then how quickly do you think gets you back to the nine to, I believe, 11% range that you've laid out as an LRP for software?
PS
Prahlad Singh
Management
Yeah. Let me take that, Dan. You know, as you saw in our results for last year, in our signals business, obviously, overall is doing extremely well. And as you pointed out with the upcoming launch of Biodesign, the introduction of Synthetica, and the launch later this year of Labgistics. Our signals business actually is in the mid of the most significant new product introduction phase in its history. You know, despite historically being focused primarily on small molecule workflows, you know, its revenue CAGR is lost solidly in the double digits and as you pointed out, above our LRP assumption of nine to 11%. So even before all these new product launches, you know, the advent of AI or how we might participate there, the business is already performing better than we expect from it over the coming years. Now let's say, as you pointed out to these new product launches, our new focus to also start gaining traction in other end markets, as material sciences. There is good potential for our growth rates in this business to accelerate even further. You know, despite having to grow off a larger base of revenue. So, no, obviously, while we are not gonna revise our LR assumption of a particular business on an earnings call, I would reiterate as I've said in the past, that we would be really disappointed if this business does not at least double in revenue over the next four to five years, which would imply something closer to a 15% organic growth rate.
DA
Daniel Anthony Arias
Analyst · Stifel. Your line is open. Please go ahead. Dan, a reminder to kindly unmute yourself by pressing star 6.
Okay. Helpful. And then maybe just on biopharma, Prahlad, you referenced biotech funding improvements as something that can help the recovery here. You're not alone. Several of your peers have done too. I'm just curious if you dig into the order book, are you finding that some of the early uptick signals that you're talking about are they coming from the companies that have successfully raised money? And so that makes you kind of feel okay about the thesis? Or, you know, is that a trend at all that you're seeing in the discovery space? I'm just trying to understand whether better biotech funding is actually something that we can count on for 2026.
PS
Prahlad Singh
Management
Yeah. Dan, I would say it's a combination of both. Obviously, you know, we started seeing some modest improvement in the fourth quarter from these customers. You know, I think it's a lot more clarity and confidence in the policy and regulatory environment that we saw compared to the earlier part of '25, which is allowing more and more meaningful decisions. And on the behavior that we see with the uptick in biotech M&A, improvement in the funding. You know, I think all of these are contributing. So I wouldn't say that there is one lever, but definitely, there's just the confidence that you are seeing and consistency. But we've got to see this for a longer period of time before we, you know, make a call and it true durable uptake. But I'm optimistic that these customers are starting to move on the right path.
OP
Operator
Operator
Your next question comes from the line of Vijay Muniyappa Kumar with Evercore ISI. Your line is open. Please go ahead.
VK
Vijay Muniyappa Kumar
Analyst · Evercore ISI. Your line is open. Please go ahead.
Hi, guys. Thank you for taking my question. First one maybe on the guidance 2% to 3%. How are you thinking about life science versus diagnostics relative to that two to three corporate? You know, your exit rate was 4%. Diagnostic, 7%, anything one-off in the 7% in the Q4.
MK
Maxwell Krakowiak
Management
Yeah. Hey, Vijay. Look. So I think as you think about the framework of the two to 3% organic growth for 2026, right. I would say life sciences is embedded at sort of a low single digit as well as diagnostics. Breaking it down further within the life sciences business, we've got life sciences solutions at low single digits. And then software at mid-single digits. Know, within that life science solutions bucket, we anticipate low single-digit growth in our reagents business and flattish performance from our instrumentation. As we look at things from a diagnostic side, we've got again, low single-digit overall for DX. And then embedded underneath that, you have reproductive health, growing at mid-single digits. Immunodiagnostics growing at low single digits, given the headwinds from China. But outside of China, we still expect our immunodiagnostics business to grow in the high single digits for 2026.
VK
Vijay Muniyappa Kumar
Analyst · Evercore ISI. Your line is open. Please go ahead.
That's helpful, Max. Maybe I'll pull out one for you on M&A environment. I'm curious how you're thinking about deal size. I know you mentioned, you know, returns metrics have to have to, you know, clear the hurdles. What is the potential for a merger of equals? Would that be on the table? Thank you.
PS
Prahlad Singh
Management
Yeah. Vijay, you know, obviously, we continue to reevaluate redeploying cash into potential M&A targets. But it has to make a strong strategic addition to the company, you know, not just for size. And, you know, our focus is on software, and life sciences reagents primarily. And then as you pointed out, you know, with our multidisciplinary, we haven't seen yet any targets that are compelling enough either from a financial profile or an expected return perspective to move forward with.
OP
Operator
Operator
Your next question comes from the line of Josh Waldman with Cleveland Research. Your line is open. Please go ahead.
JW
Josh Waldman
Analyst · Cleveland Research. Your line is open. Please go ahead.
Great. Thanks for taking my questions. Two for you. Prahlad, I wondered if you could provide more detail on what you saw within pharma biotech within the life science solutions business. I believe you mentioned no budget flush. Was the improvement in the quarter, you know, fairly evenly dispersed over the three months? And then were these more, like, longer-term projects that started to flip to orders, or did you see the actual, you know, new opportunities coming into the pipeline start to start to ratchet up?
PS
Prahlad Singh
Management
Hey, Josh. You know, let me give you an overall color. Again, I think it's, you know, very similar to what I've, you know, said during Dan's question. I think overall, what we've seen is cautious optimism and consistency in terms of order trending. I wouldn't say that there was a budget flush. I think that's the way I would think of it. But what I would say is a lot more clarity and confidence in policy and regulatory environment enables our pharma biotech customers to plan appropriately and with more degree of confidence as we get into 2026.
MK
Maxwell Krakowiak
Management
Yeah. And I would just say from a financials perspective in the fourth quarter, Josh, you know, when you look at the performance of life sciences solutions, it really kinda came in line with our expectation. You know, reagents were a little bit better than we had anticipated in the fourth quarter, coming in at approximately flattish versus a down low single-digit assumption heading into the fourth. And then from an instruments perspective, you know, although it was significantly improved from the trends that we saw over the past twelve quarters, it was a little bit lighter than what we had anticipated, but it also came in at around flattish for the quarter, which again was a significant improvement versus the trends we've seen over the past three years.
JW
Josh Waldman
Analyst · Cleveland Research. Your line is open. Please go ahead.
Okay. And then on the diagnostics business, can you run through the areas that came in better than expected, either, you know, from a product angle within the subsegments or geographic? And then how durable do you think this is going into '26? Do you think diagnostics could also be a source of upside to the two to three, or is it more really the life science business on the back of pharma biotech that could produce the upside?
MK
Maxwell Krakowiak
Management
Yeah. So I think as you look at the diagnostic performance in the fourth quarter, it did come in better than expectations. We had expected about positive mid-single-digit growth. It came in at a high single-digit growth. When you really look at the drivers of that, I would say, one, we did have continued strength globally in newborn screening, which was a tailwind to us versus our expectations. And then the second component was immunodiagnostics did a little bit better globally as well. Some of that, though, was around instrument-related timing. And so there was a little bit of additional tailwind from that. You think about how that then dovetails into 2026, you know, as I mentioned in the response, I think it was to Dan's initial question on where is upside, we definitely think we have some upside in the diagnostics business. You know, the first area I mentioned, we have a more prudent assumption around newborn screening, versus what we've seen over the past couple of years. Again, nothing's fundamentally changing there. Just a more prudent assumption, just start the year that's more in line with our LRP. Then the second dynamic is around immunodiagnostics. We've mentioned that we've taken up, again, a little bit more of a conservative assumption on immunodiagnostics in China. Just given some of the uncertainty there that's happened over the past couple years. But nothing is fundamentally changed. And should it have played out, you know, we could see some potential benefit there as well. So that's how I kinda think about the upside for diagnostics in '26. It's not just related to the life sciences business.
OP
Operator
Operator
Your next question comes from the line of Luke England Sergott with Barclays. Your line is open. Please go ahead.
LS
Luke England Sergott
Analyst · Barclays. Your line is open. Please go ahead.
Alright. Cool. Guys. Wanted to follow-up on that last China DX question on the IDX. I understand that you're taking a little bit more prudent outlook here. Does that have anything to do with kind of what peers are talking about from potential increasing of DRG or VBP plans over there to get into cancer or oncology testing? You know, I don't imagine you have a lot of exposure to those types of tests, but just what are you guys hearing over there from that perspective? And then how, you know, is that what's leading to that prudence?
MK
Maxwell Krakowiak
Management
Excuse me. Yeah. Hey, Luke. Look. So as I think about China IDX, you know, again, I think the first thing I wanna call out is, again, this will represent less than 5% of total company revenue in 2026. So this continues to just become an overall smaller piece of the portfolio. You know, I would say from a market perspective, we've not seen anything fundamentally change in the past ninety days. You know, there has been, I think, some noise around potential theoretical new policies that could come in place, but, again, those are theoretical and no real details have really been released. And then as you mentioned, some of the policy changes related to oncology, etcetera, really don't impact our business. So I would say the punch line for us is nothing has really fundamentally changed. This is really just a matter of us taking a more, you know, prudent assumption, for what's gonna happen in China IDX for 2026.
LS
Luke England Sergott
Analyst · Barclays. Your line is open. Please go ahead.
Alright. Great. And then on the instruments piece, life science instruments, you guys are assuming that's flat for '26. Just give us a look at, like, what the backlog looks like or where the demand is, you know, just kind of mirroring, I guess, the last year, any type of pacing or pickup that you guys see throughout the year?
MK
Maxwell Krakowiak
Management
No. I'd look. I would say from an interest perspective, nothing particular to call out. Again, most of our projects generally have, you know, four to five months lead time. Most of our instrumentation is customized. So we have generally good visibility from a funnel perspective. Again, we had talked about the funnel strength we were seeing heading into the fourth quarter. Again, that mostly largely played out as anticipated. It was still a really good performance for our instruments business in the fourth quarter. And so I would say as you think about the flattish assumption, again, this is assuming a similar CapEx environment that we just, you know, faced in 2025. And I think there's been some real indicators that, you know, things could be improving, but we need to see it over, you know, the course of a couple quarters before we start rolling that into the numbers.
OP
Operator
Operator
Your next question comes from the line of Andrew Cooper with Raymond James. Your line is open. Please go ahead.
AC
Andrew Cooper
Analyst · Raymond James. Your line is open. Please go ahead.
Hey, everybody. Thanks for the questions. Maybe just to start with margins. Can you just give a little bit more of a breakdown of some of the moving parts for the year, especially the first quarter? I mean, we're used to some drop from 4Q to 1Q, but would you call normal versus the tariffs versus FX versus cost-saving program costs? You know, just help us some of those moving pieces would be great.
MK
Maxwell Krakowiak
Management
Yeah. Absolutely. Hey, Andrew. So I think look. When you think about things from an operating margin perspective, you know, it is, to your point, normal for us to have Q1 be, I would say, several hundred basis points below our full year operating margin. Then normally, Q2, Q3 is kind of in line with full year, and the fourth quarter is, you know, several hundred basis points above our full year operating margin. You know, I think as you look at 2026, both the first quarter and the second quarter would be, I would say, lighter than normal, and there's for a couple reasons for that. First, as you look at the first quarter, you do have the impact of the extra week, which is an operating margin headwind for us. And then secondly, you know, as we mentioned in the prepared remarks, our cost are gonna continuously be executed throughout the first half of the year without being fully completed until the end of the second quarter. So you will get a little bit of a cost productivity benefit in the second half once those are 100% actioned.
AC
Andrew Cooper
Analyst · Raymond James. Your line is open. Please go ahead.
Okay. Helpful. And then maybe just as follow-up. You know, high level launching products sometimes into what we'd all admit is a challenging kind of end market is always a little bit tricky. I mean, have you guys calibrated some of the software launch expectations and, you know, is it different given, I think, all the new launches are more SaaS oriented versus kind of on-prem upfront license fee? But, you know, how does this constrained capital environment impact the way you go to market with these newer products?
PS
Prahlad Singh
Management
If at all? Yeah. Andrew, I mean, the way our software business is set up is, you know, you just essentially, you know, you have an installed base, and most of these product launches go into the signal suite. So it is more of an upsell opportunity that comes in, and then that rolls over. In some cases, when the contract come up for renewal, in some cases based on the customer's needs. That they might have an immediate need for it. So, you know, and as we've talked about earlier, right, most of what you know, our product launches with us around biodesign or logistics are based on custom demand and asks from the user group that the team puts in place. So there has been more of a pull for this than a push of a new NPIs. We expect them to start gaining traction earlier as we move from small molecules to larger molecules with biodesign. But generally, it takes a few quarters for them to start gaining traction.
OP
Operator
Operator
Your next question comes from the line of Daniel Louis Leonard with UBS. Your line is open. Please go ahead.
DL
Daniel Louis Leonard
Analyst · UBS. Your line is open. Please go ahead.
Thank you very much. I've got another China diagnostic question. Fully appreciate that China immunodiagnostics is less than 5% of your revenue, but how confident are you that this returns to growth in the second half of the year?
MK
Maxwell Krakowiak
Management
Yeah. Hey, Dan. Thanks for the question. You know, again, it's on China IDX. I would say that, you know, as we have taken a more prudent assumption, I would say we are no longer forecasting a return to low single-digit growth in the second half of the year. We expect it to now be, I would say, down slightly in the second half of the year. And, again, that just goes to what we're calling, you know, a more prudent and conservative assumption as we head into 2026. Nothing fundamentally changed throughout the underlying market conditions.
DL
Daniel Louis Leonard
Analyst · UBS. Your line is open. Please go ahead.
Thank you for that clarification. And an unrelated follow-up, I could just, you know, use some help better understanding how you're framing the economic opportunity for that AI drug discovery offering and software. Thank you.
PS
Prahlad Singh
Management
Yeah, Dan. I mean, look. The fact is that as, you know, we talked about at a health care conference earlier during the year, and we went through what Synthetica does. We really feel it's a very exciting area for us as a company. And then I think, you know, I would be bold enough to say for the industry as a whole. You know, Synthetica for me is not an AI. It's even more potentially important in the near term as it is in the longer term because what it does is it brings to action how drug discovery happens. You know, when you think of it today, you move from only being a wet lab to doing in silico modeling and being able to then link it back to what happens in the wet lab, bring it back onto the Synthetica plot. The signal suite provides a platform or a marketplace where all of this can happen in one place without you having to be a software expert. I think that's the value of Synthetica. It provides a federated model where you are able to curate put AI models on one platform that are validated and be able to use them and enable drug discovery to happen in an efficient form. I think in the longer term, the benefit of what you will see from that is not just on productivity and efficiency but also acceleration of drug discovery. So we really are, needless to say, very excited about Synthetica. And then in the first one, of, hopefully, a few is the partnership that we have announced with Lilly on that initiative.
OP
Operator
Operator
Your next question comes from the line of Brandon Couillard with Wells Fargo. Your line is open. Please go ahead.
BC
Brandon Couillard
Analyst · Wells Fargo. Your line is open. Please go ahead.
Hey. Good morning. Thanks for taking the questions. Just one for me. Max, free cash flow conversions has improved over the last two years. I didn't hear you talk about a target for this year, but can you give us a little more color on the levers to improvement there and kind of where you're seeing free cash flow shake out for '26? Thanks.
MK
Maxwell Krakowiak
Management
Hey, Brandon. Yeah. Look. I think from a free cash flow conversion standpoint, we've continued to execute, I would say, incredibly well over the couple years. I think if you look on average over the past couple years, it's been close to a 90% free cash flow conversion for us, which is obviously, again, a dramatic change from where we were. You know, if you go back, you know, a handful of years ago, we were hovering kind of around 70% conversion. I think there's really been a couple of drivers of that. You know? One, we continue to execute on some of the working capital initiatives that we have across the company. Two, you know, I would say it's a benefit of the portfolio we have now with the higher reoccurring mix of product. And then three, you know, we've really made sure that everyone across the company is incentivized and has targets from a cash flow perspective, which is really starting to pay a lot of dividends. You know, I think as you look at 2026 and the expectation, we do expect to have continued momentum. You know, our LRP kind of calls for 85% conversion or greater a given year, and I think that's the expectation we have for 2026 as well.
OP
Operator
Operator
Your next question comes from the line of Catherine Schulte with Baird. Your line is open. Please go ahead.
CS
Catherine Schulte
Analyst · Baird. Your line is open. Please go ahead.
Hey, guys. Thanks for the question. Maybe just one from me as well. Can you just size how much benefit 1Q organic growth has from the extra week? And any other pacing commentary on how to think about organic growth for the rest of the year, you know, maybe what's implied in the guide for a 4Q exit rate?
MK
Maxwell Krakowiak
Management
Yeah. Hey, Catherine. Look. So I'll actually answer the second part there first. You know, from an organic growth cadence over the course of the year, you know, we're calling for two to three here in the first quarter, which is in line with the full year. I would say we're expecting relatively consistent performance around that, you know, 2% to 3% for each quarter of the year. So I'd say relatively consistent there. And then I think as you look at the extra week, financials, just to talk through some of the different moving pieces across the entire P&L. You know, from an organic growth perspective, we expect it to be about a 100 bps tailwind to OG in the first quarter. You know, that's roughly 20 basis points for the full year. You know, the benefit from a revenue perspective, the majority of that tailwind is really from our life sciences reagents business as we pick up a couple extra selling days. Then there's a little bit of service and software, contract amortization. We are not expecting an impact across our DX or CapEx purchases from our customers. I think then when you look at it from a margin perspective, it is a headwind for us, as you do have an extra week of cost, which is predominantly labor-driven. Obviously, you have to pay your employees for that extra week. And so that ends up actually being a margin headwind for us, which is, again, leading to the lighter than normal Q1 margins. From an EPS perspective, you know, it's roughly about a $0.06 headwind that we're facing for the first quarter related to that extra week due to the margin, and then there's a little bit of extra net interest expense below the line as well.
OP
Operator
Operator
Your final question will come from the line of Tycho Peterson with Jefferies. Your line is open. Please go ahead.
TP
Tycho Peterson
Analyst
Hey. Thanks. I wanted to touch on reagents. Appreciate all the color and, you know, 4Q a little bit better. But curious, last quarter, was noise on margins, discounting, promotional activity by some of your peers. Can you just talk a little bit about competitive dynamics on the reagent side? How you're thinking about pricing and margins there in consumables if top line does come back a bit?
PS
Prahlad Singh
Management
Yeah. Hey, Tycho. I think as Max pointed out, you know, we feel very good about the way the business has been playing out. And I think we've taken some share. So we've not seen any margin dilution per se on the reagents business. And it continues to do well for us and bodes well for the way we are looking at how it is in 2026. So I wouldn't say that, you know, from our perspective, there was any noise either in terms of margins or share. I think we did well on both.
TP
Tycho Peterson
Analyst
Okay. And then the second question and last one is just on instruments. Curious if we can get a little more color just on the various buckets, how you're thinking about, you know, liquid handling, in vivo, high content screening, obviously, some GLP benefit there. Maybe just talk about four buckets on the instrument side and what's baked in for each of those this year.
MK
Maxwell Krakowiak
Management
Yeah. Hey, Tycho. Look. From an instruments perspective, we're not gonna guide by, you know, SOPs sub-product line. But I think as you think about the trends, right, particularly around high content screening, you know, high content screening for us, we had mentioned, was looking at a strong fourth quarter. It did end up being strong, I would say, double-digit growth in the fourth quarter as we continue to see momentum there, which, again, really is sold into the pharma biotech environment. So from that perspective, we expect, you know, the high content screening momentum to continue in 2026. And I would say, you know, the rest of the portfolio, again, expect it to be, I would say, relatively, you know, flattish as we've kinda come off the lower baselines here exiting 2025.
OP
Operator
Operator
There are no further questions at this time. I will now turn the call back to Steve for closing remarks.
SW
Stephen Barr Willoughby
Management
Thank you, Nicole. Thanks, everyone. We look forward to catching up with you over the remainder of this week and hopefully see you in person in upcoming conferences the next month or so. Have a good day.