Robert Rosiello
Analyst · Deutsche Bank. Please go ahead
Slide #12 shows where the change is taking place. It is primarily U.S. dermatology and GI with other various small changes attributed to other factors. Let me start with dermatology. The current budget represents a $410 million takedown of revenue. This reduction is driven by lower script volume, lower fill rates, speed bumps and access program combined with lower ASPs and overall higher managed care rebates. For Xifaxan, it represents a $390 million reduction relative to our previous expectations. Xifaxan has delivered strong growth, but it is less than our expectations, and we believe the potential. Disruption, sales force turnover, changes in leadership, shifts in strategy, and increase in enrollments in high deductible plans, which we believe for the first time extended into the second quarter have contributed to our lower forecast. The third bucket of roughly $300 million includes other units, additional pricing reductions, such as GPO rebates for Nitropress and Isuprel. Slide 13, shows what drives the ramp to the midpoints of our guidance. Let me walk through it. So the first is today we’re announcing $1.27 in Q1. The second would be assuming a Q1 run rate performance for the rest of the year, pure math would add $3.81. If we add to that, the historic seasonality in typical second-half ramp characteristic in our business, what we might call the typical 40/60, that would add an additional $1.25 and we net out the GPO rebate that we recently announced for Isuprel and Nitropress. The fixing derm and Salix and the growth acceleration would provide additional $0.50, again, that would net out the new managed care contracts, other markets and particularly emerging growth, which we feel very good about would deliver an additional $0.17 and then we would net out of that subtraction of generic erosion, for example, Zegerid and other potential pricing actions that we might take. Take this together, this would deliver the midpoint of our guidance, and we see upsides in improving the ASPs and volumes, particularly our dermatology business through engagement with independent pharmacies, adjustments to co-pays and buy-downs, and improvement in the prior off process. Now, I’d like to turn the call over to Linda, our Treasurer to discuss our debt and liquidity position.