David P. King - President and Chief Executive Officer
Analyst · Lehman Brothers. Please proceed
Thank you, Brad. As you can see, we had a very solid second quarter. Our US business grew 3.6% with volume increasing 1.3% in spite of a difficult comparable in the second quarter of 2007 which included significant growth from UnitedHealthcare and being in network with Aetna. Also as we have been saying, the economy has had an effect on our business which we believe is reflected in both, our volume growth and collection experience. Our view of volume growth in the second half as well as the impact of increasing bad debt are the drivers of our adjustment to guidance for the balance of the year. In spite of these near-term challenges, we firmly believe that the future of our company and the industry has never been brighter. In a moment, I will discuss what we see as the two greatest drivers of growth and margins, but I would first like to give you some additional information about our 2010 plan. LabCorp 2010 is a comprehensive initiative to drive service, quality, and operational improvements and to create a platform to allow us to fully realize the growth opportunities I am about to discuss. Our focus on improving quality and service will not only support growth, it will allow us to lower our expense base through greater operational efficiency. For example as we improve our logistics and testing infrastructure, we reduce the potential for error in sample handling and create savings from things like improved courier routes and a footprint with fewer, more efficient testing facilities. These improvements are already underway. Overall, we expect that the 2010 plan will generate net savings of at least $100 million from our current annual expense run rate by 2011. Our savings will come primarily from adjustments in our footprint, greater efficiencies in our logistics network, and improved supply chain management. Brad Smith will discuss more details on the timing of the savings in a few minutes. Now, let's turn to our key drivers of long-term growth, esoteric testing and personalized medicine. We have long been the leader in esoteric and genomic testing. These tests continue to generate almost 35% of our revenue and contribute significantly to our EBITDA margins. In this quarter, esoteric and genomic testing volumes grew by 5%, well above growth in the core business. A major driver of growth in esoteric testing is vitamin D. The understanding of the importance of vitamin D testing has vastly increased over the last two years, and we have seen the volume of this test grow exponentially. Many Americans are vitamin D deficient with significant negative consequences for their health. Study report that vitamin D deficiencies increase risk of prostate, colon, and breast cancer as well as osteoporosis. Here again the laboratory industry leads the way in improving patient care and patient outcomes. We continue to lead the industry in bringing new clinically relevant esoteric tests to our clients and their patients. We are very proud that in this quarter we introduced OvaSure, our ovarian cancer screening test for high-risk women. This test developed by researchers at Yale University is the first clinically reliable screening test for the approximately 10 million women who have a high risk for the development of ovarian cancer. Ovarian cancer is one of most lethal cancers because it is typically diagnosed at a late stage at which time the chances of survival are poor. This year it is estimated that more than 21,000 women will be diagnosed with ovarian cancer and more than 15,000 will die from the disease. An effective screening test will help improve early detection and patient outcomes. We have seen significant interest in the test from physicians, patients, and payers, and already see adoption. We look forward to additional publications on the Phase III trial. We lost the number of other noteworthy tests in the esoteric and genomic arena in the first half of this year. First a breast cancer prognosis gene expression assay developed in collaboration with Celera Diagnostics. This gene expression test predicts the risk of metastasis in breast cancer patients, helping physicians to select the right course of treatment and improving patient outcomes. Second, an assay for detecting the presence of a key tissue marker, GST-Pi in prostate cancer. LabCorp was the first full-service, national laboratory in the United States to launch this assay which helps physicians assess the risk of prostate cancer in men with consistently elevated PSA but repeatedly negative biopsies. Third we announced the availability of ColoSure, the most sensitive, in guideline, noninvasive colorectal cancer screening test available. ColoSure examines DNA in colon cells to enhance the potential for detecting and treating colorectal cancer in its early or localized stage when the chance of survival is greatest. We are pleased with our progress in esoteric and Genomic testing and continue to believe that it will generate 40% of our revenue in the next three to five years. We also see great opportunity in personalized medicine on at least two fronts. First serving as a catalyst for the creation of targeted therapeutics and companion diagnostics and second providing a comprehensive service to help physicians personalize care for diseases whose course of treatment is driven heavily by lab results. We believe we are the industry leader in both of these areas and that they will provide significant growth for us. In companion diagnostics, we led by introducing HIV viral load followed with HIV and HCV genotyping. In 2005, we were the first commercial laboratory to introduce the test for the HLA-B-57 mutation that identifies hypersensitivity to back of ear an Aids treatment drug. In this quarter we continued our leadership in companion diagnostics. We reached an agreement Siemens to discuss future possibilities to co-development new clinical diagnostics tests in companion diagnostics, metabolic syndrome, oncology, and diabetes. We entered into an exclusive alliance to develop and commercialize a series of diagnostic test for genetic markers identified by Vanda Pharmaceuticals in the course of its clinical development of a Fanapta novel, atypical, anti-psychotic drug candidate under review for the treatment of schizophrenia. We offered a genetic test to detect the K-ras mutation. As you know, mutations in the K-ras gene are common among patients with colorectal cancer and can better define which patients will benefit from particular drug treatment. At the recent ASCO meeting it was suggested that K-ras testing should routinely be conducted immediately after diagnosis of colorectal cancer to ensure the best treatment strategy for each individual patient. We continued our innovative collaboration with Medco to identify non-responders to tamoxifen before they receive the drug. This partnership involves performing a diagnostic test on each patient who is prescribed tamoxifen to determine whether they have the receptor that will make the drug efficacious. If this receptor is not present, tamoxifen therapy will not be successful. To further these initiatives, we will soon be breaking ground on a state-of-the-art biorepository in Kannapolis, North Carolina, that we will be developing in partnership with Duke University and several pharmaceutical manufacturers. This biorepository along with our newly acquired Tandem Labs ability to do rapid bio-marker identification are two critical components of our plan to create the most comprehensive companion diagnostic platform in the industry. The proof of our success in this area is the 71% year-over-year revenue growth in our clinical trials business. This platform has broad application including the ability to support drug rescue programs which we have been exploring in our work with Arca biosciences. We have recently seen exciting new data from Arca about bucindolol indicating that genetic testing allows U.S. to accurately identify patients who will benefit from the drug. We are leveraging our capabilities in assay development, data and informatics, physician and patient access, and distribution to become the partner of choice for development of companion diagnostics. The second important opportunity around personalized medicine is our outcome improvement programs. You have heard me talk about Litholink, our kidney stone management program that reduces stone recurrence by 80% and saves the healthcare system substantial costs in treating recurrent stone formers. This decision support model provides physicians with patient-specific information about how to treat disease and improve outcomes. And it has grown rapidly as physicians, patients, and payers adopt and embrace the model. We are pleased to announce that in August we will launch a new service to help physicians address a much larger crisis in the United States, Chronic Kidney Disease. There are more than 26 million Americans with stage-three or four Chronic Kidney Disease, and astonishingly, approximately 90% do not know they have the disease. CKD prevalence has increased by 30% in the past decade, driven by the co morbidities of diabetes, hypertension, cardiovascular disease, and obesity. CKD is a chronic progressive disease with exceptionally high morbidity and mortality. And it is a major health disparity issue. It is estimated that stage three and four CKD cost over $20 million per year with an additional $17 billion spent on dialysis patients. Yet in a seminal study of CKD treatment nearly 50% of patients did not receive a single intervention associated with optimal care in the year before going on dialysis. Our program has two goals, better patient outcomes and cost reduction. We will achieve better outcomes by identifying patients with stage three and four disease in time to treat them correctly and postpone or avoid dialysis. The savings will follow. I am pleased that we have recruited a pre-eminent advisory board to assist U.S. in designing our CKD program. We are both flattered and proud that 15 of the most prominent experts in the U.S. and Canada in Chronic Kidney Disease are working with LabCorp to attack this terrible condition. We are fully committed to the success of this program, with others like it to follow. Now I would like to update our guidance for 2008. Excluding the impact of restructuring and other special charges and share repurchase activity after June 30, our guidance is compared to 2007, LabCorp expects 2008 revenue growth of approximately 10.3 to 11.3%. EBITDA margins of approximately 25.0 to 25.3% of revenues, diluted earnings per share in the range of $4.54 to $4.66, operating cash flow of approximately $750 million to $770 million, excluding any transition payments to United HealthCare. Capital expenditures of approximately $140 million to $160 million, including capital dedicated to our 2010 plan, and net interest expense of approximately $70 million. Now Brad Smith will review anticipated questions and our specific answers to those questions.