Earnings Labs

Repligen Corporation (RGEN)

Q4 2024 Earnings Call· Thu, Feb 20, 2025

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Transcript

Operator

Operator

Good day, ladies and gentlemen. And welcome to Repligen Corporation's Fourth Quarter of 2024 Earnings Conference Call. My name is MJ, and I will be your coordinator. All participants will be in listen-only mode. [Operator Instructions] I would now like to turn the call over to your host for today’s call, Sondra Newman, Head of Investor Relations. Please go ahead.

Sondra Newman

Analyst

Thank you. And welcome to our fourth quarter of 2024 report. On this call, we will cover business highlights and financial performance for the three and 12-month periods ending December 31, 2024, and we will provide financial guidance for the full year of 2025. Joining us on the call today are Repligen's President and Chief Executive Officer, Olivier Loeillot, and our Chief Financial Officer, Jason Garland. As a reminder, the forward-looking statements that we make during this call, including those regarding our business goals and expectations for the financial performance of the company, are subject to risks and uncertainties that may cause actual events or results to differ. Additional information concerning risks related to our business is included in our quarterly reports on Form 10-Q, our annual report on Form 10-K, and other current reports on 8-K, including the report that we're filing today as well as other filings that we make with the Securities and Exchange Commission. Today's comments reflect management's current views, which could change as a result of new information, future events or otherwise. The company does not obligate or commit itself to update forward-looking statements, except as required by law. During this call, we are providing non-GAAP financial results and guidance, unless otherwise noted. Reconciliations of GAAP to non-GAAP financial measures are included in the press release that we issued this morning, which is posted to Repligen's website and on sec.gov. Adjusted non-GAAP figures in today's report, include the following, non-COVID and organic revenue and or revenue growth. Cost of goods sold, gross profit and gross margin, operating expenses, including R&D and SG&A, income from operations and operating margin. Tax rate on pretax income, net income, diluted earnings per share, EBITDA and adjusted EBITDA and adjusted EBITDA margins. These adjusted financial figures should not be viewed as an alternative to GAAP measures, but are intended to best reflect the performance of our ongoing operations. Now, let me turn the call over to Olivier.

Olivier Loeillot

Analyst · Stifel

Thank you, Sondra. Good morning, everyone and welcome to our 2024 fourth quarter and yearend results. We are happy with the way we finish 2024 and in addition to reporting our financial results in detail, we will share our 2025 strategic priorities and provide financial guidance for the new year. We have a lot of reasons to be positive about 2025 as we put specific 2024 headwinds behind us, and we see a return to growth for the bioprocessing market. I'm pleased to share that we achieved the midpoint of our November guidance, the reinforced quarter revenue of $167.5 million and full year revenue of $634.4 million despite a $3.5 million exchange rate headwind in the quarter. Product differentiation, excellent execution by our team and better market conditions have enabled us to deliver a 13% revenue growth ex-COVID in the fourth quarter versus the previous year. Our orders were also very strong in the fourth quarter with the highest order intake we've had since quarter two of 2022, and it was the sixth straight quarter that orders outpaced non-COVID revenue. In quarter four, we were delighted by the strong performance from CDMOs and equipment, key market sectors that have been slower to recover. With this momentum, and as our funnel continues to grow, we are well positioned as we enter 2025. After a great rebound in quarter three, our CDMO business had an even better quarter with sales and orders up high double digits sequentially. In fact, thanks to that very strong CDMO finish, our full year 2024 sales growth was similar at CDMO and pharma, both up high single digits. We saw a similar pattern for equipment. Following a solid quarter three, equipment was another important standout in the fourth quarter with both sales and orders up more than…

Jason Garland

Analyst · RBC Capital Markets

Thank you, Olivier, and good morning, everyone. Today, we are reporting our financial results for the fourth quarter and full year of 2024 and providing financial guidance for 2025. Unless otherwise noted, all financial measures discussed reflect adjusted non-GAAP measures. As shared in our press release this morning, we delivered fourth quarter revenue of approximately $168 million and full year revenue of $634 million, achieving the midpoint of our guidance despite a $3.5 million exchange rate headwind in the quarter. This is a reported increase of 1% for the fourth quarter or up 3% on an organic basis, which excludes the impact of acquisitions and currency headwinds. As Olivier mentioned earlier, our fourth quarter non-COVID revenue growth was up 13%, which we believe is more representative of our performance. There was no COVID-related revenue during the fourth quarter of 2024 versus $19 million in 2023. Our full year 2024 revenue was flat and up 3% on a non-COVID basis. FX was a net headwind of one point for the year, and acquisitions contributed approximately two points of growth. As Olivier shared color on our product franchise performance, I'll provide more detail on the performance across the global regions, starting with revenue, where North America represented approximately 50% of our total full year revenue, Europe represented 34%, and Asia-Pacific and the rest of the world represented 16%. North America had a great fourth quarter, being up 20% in revenue. Asia was equally strong in 4Q with 20% revenue growth, inclusive of China, while Europe was down 25% due to COVID and protein headwinds. For the full year 2024, it was encouraging to see our largest region, North America, delivering 12% revenue growth. Asia, excluding China, was also up 12%, and for Europe, non-COVID revenue growth was a 2% decline, while our…

Operator

Operator

[Operator Instructions] Today's first question comes from Dan Arias with Stifel.

Dan Arias

Analyst · Stifel

Good morning, guys. Thanks for the questions here. Olivier, maybe a place to start would just be to ask how things have evolved here. I mean, last quarter, you felt good about CDMOs and capital equipment. You were cautious on China and emerging biotech. Is there anything that has shifted at all? It seems like order activity stepped up. But I would love to just hear what you think is most important here to start the year. And then I guess I would specifically be interested in those Tier 2 CDMO accounts that showed some good signs of life last quarter. How confident are you in the sustainability of the improvement that it looks like you are seeing here? Thank you.

Olivier Loeillot

Analyst · Stifel

Yes. So, thanks, Dan, for the question. So, you are absolutely right. I mean, what was really important for us in quarter four was a confirmation like both CDMO and capital equipment turnaround that we started to see in quarter three was really fully confirmed. And in fact, we had a huge acceleration on both sides. I mean, particularly on the CDMO side where we had sales and orders increasing tremendously in quarter four. I mean, our sales were up more than 40% and our orders were up more than 11%, which as mentioned in the script, has brought us back to almost the same amount of growth at CDMO as we had at pharma for the entire year. And we love that because we think CDMOs are like that reflection of the health of the entire ecosystem. And you mentioned the big guys. In fact, growth came from both Tier 1 and Tier 2 CDMOs. But yes, particularly at the big guys, we see a lot of traction happening right now. They've announced a lot of big deals. And I think the entire ecosystem is starting to benefit from it right now for sure. And then on capital equipment, that's the other one where probably we saw an improvement earlier than others. And we had an incredible confirmation in quarter four. I mean, our sales were up more than 20% and our orders were up 25% versus quarter four of last year. So we've seen a huge improvement and we think our state of the art system offering is definitely positioning us very well on that side.

Operator

Operator

The next question comes from Rachel Vatnsdal with J.P. Morgan.

Rachel Vatnsdal

Analyst · J.P. Morgan

Perfect. Good morning and thank you for taking the questions, you guys. So I wanted to dig into the opportunity with ATF here. You mentioned that ATF grew above 50% for the year. So could you walk us through how much revenue did you guys do in ATF in 2024? And then separately, you've talked about getting specked into a blockbuster drug for ATF. You've also alluded to the fact that you may get specked into a second blockbuster drug. So how should we think about the timing of that benefit of getting specked in? Is there anything assumed for these blockbuster opportunities into 2025 guidance or would that be upside at this point?

Olivier Loeillot

Analyst · J.P. Morgan

Yes. Thanks, Rachel. So as the filtration business is the biggest of all businesses. It's more than half, about 60% of our total business. It did about $373 million in 2024. We were never given the exact numbers of ATF, but it's the biggest part of the filtration business we have right now. And we are benefiting, obviously, from the fact we got designing in many late phases, if not commercial drugs, over the last 12 to 18 months. So what I mentioned in quarter three is a blockbuster that is on the market. And the typical timeline when you get the confirmation you're designing in a commercial drug, you're getting the orders within a quarter, you're going to deliver the hardware probably within the next six to 12 months, and then you start to see the consumable sales happening probably after a year or so. So for us, it's all about making sure we have wins quarter by quarter and then that we have somehow more and more of this installed base because then the consumable share is going to increase. And in fact, for the first time in 2024, our consumables ATF sales were above our hardware sales, which is a sign like indeed the installed base is becoming really significant right now. So the last piece I would mention is we've been very successful getting designing with ATF at all CDMOs. In fact, nine of the top 10 CDMOs are using ATF very broadly here. And now a lot of pharma companies are also starting to use ATF. So the best is still to come. So a lot of tailwind coming on the consumable side for sure.

Operator

Operator

The next question is from Puneet Souda with Leerink Partners.

Puneet Souda

Analyst · Leerink Partners

Yes, hi, Olivier, Jason. Thanks for taking my questions here. I'll wrap up in one question. I think the question here is just in terms of how sustainable are the order trends that you are seeing, just given the backdrop of what we have seen from the peers, a recovery that hasn't been as smooth as one would have expected even back in ‘23 or ‘24. Just sort of trying to get a sense of that and then wondering if you can elaborate if, January and February order trends were also comparable to the Q4 and or maybe even the stronger, if you could elaborate on that. Thank you.

Olivier Loeillot

Analyst · Leerink Partners

Yes, absolutely. So I'll start probably by talking about the fact in 2024, our order intake has increased every single quarter after the previous one. So basically from quarter one to quarter two, quarter two to quarter three, quarter three to quarter four. And in fact, between quarter four and quarter one, our order intake went up by 18%. So that's what we are very happy about because we've seen a progress of order intake really quarter by quarter. I would add to that, and I know we don't want to talk too much about book-to-bill anymore, but as you know, we've been the first one really seeing book-to-bill ratio above one, and now it's like for six to seven quarters in a row. So that's why we're also very confident that the return to growth we've been experiencing now is very sustainable. And the last piece I would mention is really, if I look at all of our franchises, excluding protein, our order intake in 2024 was a double digit. So that's another very strong signal, like we've got a strong portfolio of products. We recently said like about 80% of our portfolio is very differentiated. And I think that's a reflection of the growth we've seen in orders for the last several quarters now.

Puneet Souda

Analyst · Leerink Partners

And just to be clear, in the quarter itself, are you seeing any trends that give you confidence overall?

Olivier Loeillot

Analyst · Leerink Partners

Yes. So as you know, very well, Puneet, we typically don't comment on the current quarter. All I can say is things are doing well and we're absolutely fine so far, yes.

Operator

Operator

The next question comes from Matt Larew with William Blair.

Matt Larew

Analyst · William Blair

Hi, good morning. It looks like based on recent order trends that there is pretty good visibility across the portfolio. Of course, the one area that really, you're pawned for at different ‘25 and ‘24 is proteins. And you alluded to what that is. Could you really speak to the visibility on the protein side to that 10% to 15% growth and maybe within that comment on any early traction you're seeing with the new product launch and anticipation of other product launches this year?

Olivier Loeillot

Analyst · William Blair

Yes. Thanks, Matt, for the question. We knew like 2024 would be a tough year for protein. And in fact, we were thinking we have probably $30 million to $35 million of headwind and it played out a little bit better than we expected. Not that much better, but a little bit better. And the good news is, as we knew it was a reset year. I mean, the business at the top two OEM partners we had is almost down to zero right now, which means like no more headwind coming from that side. And what has been really good for us in 2024 is we've progressed really strongly on the rest of the portfolio. And particularly on our Avitide and our upcoming Tantti business, where we won several deals for custom ligands or custom resin developments. And as you just mentioned, we also launched our first resin using the Tantti beads, the double-stranded RNA resin, which has got really good traction so far. But the best is still to come. I mean, we've got several product launches planned in 2025, focusing mostly on new modalities. So we really think like from this point we are today, we should be back to the double-digit growth that we experienced before the hit with the other OEM partners. And what I love even more than anything else is we've got our destiny in our hands much more today. I mean, it's so good that we can develop and launch our resin because then we can really control our own commercial activities to the large extent. And then the collaboration with Purolite on the other side is also doing very well. And we're working very closely with our partners on monoclonal antibody here.

Operator

Operator

The next question comes from Jacob Johnson with Stephens.

Jacob Johnson

Analyst · Stephens

Hey, good morning, everybody. Maybe following up on Rachel's ATF question kind of in a bigger picture way, Olivier, you mentioned CDMOs have adopted ATF. It seems like some traction with pharma recently. Why are you seeing these wins with ATF now? It's a technology that's been around for a while. Are these seeds that were planted years ago? Is this key account strategy, good execution by the sales team? Just curious kind of qualitatively what's been driving the ATF wins recently.

Olivier Loeillot

Analyst · Stephens

Yes, no, it's a great question, Jacob. And it's a bit of all what you mentioned. I mean, so what people may not realize is we've got a lab scale ATF solution, which is where people typically start putting their hand on the ATF technology, meaning like typically maybe three, four, five years ago. Also, some of these companies would have started testing the technology at the lab scale and realizing that it was working really well. And then they might have decided to start getting it up a few years later and then have a couple of great successes operating at larger scale and so on. And then, how it is with new technologies. Once the technology starts to be really well known in the industry, people are probably capable to adopt that faster and then just decide to move on maybe in a record time frame versus what they would have done before. So if I look at the last big win, we talked about in quarter three, which is a commercial drug, I mean, it's fair to say this one has been moving really fast. And we start to see companies telling us, hey, we've got the proof of concept. This technology works really well. So and considering the regulatory changes are limited, we can probably activate implementing that technology faster than we would implement a technology that is not known at all in the industry. So it's a bit of a mix. You've got people who are faster than others. You've got people who have been having their hand on the technology for several years. But all I can tell you is we still have a lot of wins, new wins coming, which is why we are so confident about the future. And the wins are not beyond monoclonal antibodies where we start to see multiple wins on the new modality side using ATF as well.

Operator

Operator

The next question is from Conor McNamara with RBC Capital Markets.

Conor McNamara

Analyst · RBC Capital Markets

Hey, thanks for taking the questions and congrats on a solid quarter. Can you just talk about what end market assumptions you've incorporated in your fiscal ‘25 guided to a Q1 that's going to be at the low end of your guidance range? And then that would assume there's an acceleration for you guys. Is that, are you assuming that end markets kind of return to historic growth rates by the end of the year? Or is it more Repligen specific that's driving that acceleration throughout the year?

Olivier Loeillot

Analyst · RBC Capital Markets

Yes, that's a really good question, Conor. I mean, again, I think we see ourselves a bit different than others from the point of view, again, 80% of our portfolio is very differentiated. So I can't really talk about the global markets and then how people would see it from their own angle at this stage. Well, what we see from our side is we are probably back to the same pattern we experienced before COVID, where typically H2 is a little bit higher than H1, where the strongest quarter in the year is always quarter four. And then quarter one, quarter three being a little bit lower, meaning we're going to see such an acceleration from quarter one to quarter two, that kind of the pattern we always experienced before COVID. And we think we're pretty much back to the same situation for us in 2025 year.

Conor McNamara

Analyst · RBC Capital Markets

Great, thanks. And then just on pricing, can you quantify pricing impact in ‘24 and what you've incorporated in the ‘25 guide? Thanks for the question.

Jason Garland

Analyst · RBC Capital Markets

Yes, so we achieved given that low single digit pricing back to the historical levels that we've traditionally seen and expect a similar case in 2025. So we feel like from that angle, our product differentiation allows us to capture price, but to do it modestly and balance that with our customer relationships and again, keeping our products cost competitive for their solution. So we'll continue on that same trend.

Operator

Operator

The next question comes from Matt Hewitt with Craig Hallum.

Matt Hewitt

Analyst · Craig Hallum

Good morning and congratulations on the strong finish to the year. A couple of questions regarding the equipment sales. Obviously, you're seeing a strong recovery there. Was there any budget flush impact in Q4? And I guess another question would be looking at your peers, some of them are still talking about headwinds on the equipment side. What do you think is the key differentiator for you versus maybe some of the issues that your peers are still having? Thank you.

Olivier Loeillot

Analyst · Craig Hallum

Yes, thanks, Matt, for the question. I think we need to look at hardware from one point of view, which is you've got what I call really the lab small scale type of hardware on one side, which is the C Tech part of our business. And then you've got more of the manufacturing larger scale type of hardware, which is what we call ARTeSYN on one side and large scale system on the other side. So if I look at the first bucket, which is more of the small scale type of hardware, we know like there is always a very strong quarter four and we experienced it. I mean, we said it in the script. I mean, we had the record quarter ever for since we acquired C Tech in terms of both orders and sales in quarter four. And I want to say probably half of it is like beginning of a start of a recovery for those smaller type of hardware. And I think some of these analytical company have seen the same, I think, in quarter four. And then the other half is definitely coming from the seasonality where quarter four is always a quarter where you want to use your budget and then the order intake is always the highest ever. But then for the rest of the portfolio, which is really what I call the manufacturing and hardware piece, I think the situation is different. And then here, Matt, I want to think like the fact we launch products that are real state of the art, really high tech and not only high tech from a hardware point of view, but combined with our PAT flow, VPX technology, which is not included is almost 20% to 25% of every system we're selling is giving us a huge competitive advantage, which is why we are certainly gaining market share on that side. And then here, I mean, it depends. I mean, the fact we see CDMOs recovering so well, makes me feel like that's one of the reasons why we start to see so much more CapEx spending again coming from CDMO. And we've seen quite a bit of it in quarter four. And so really on that side, which is a manufacturing hardware, I think we're gaining market share with probably better products, more features with our PAT technologies, and certainly also very focused on new modalities, which, as you know, with the launch of RS 10 in particular, we've had a lot of wins over the last several quarters now.

Operator

Operator

The next question is from Subbu Nambi with Guggenheim Securities.

Subbu Nambi

Analyst · Guggenheim Securities

Hey, guys. Thank you for taking my question. And a follow up to the previous question. First off, thank you for clearly laying it out on how you achieve your 2025 guidance. Outside of ATF, I wanted to get additional color on why are you focused on newer modalities and PAT in specific? Are there areas where you see there is an unmet need and therefore winning accounts is easier or versus displacing some of the larger players?

Olivier Loeillot

Analyst · Guggenheim Securities

Yes. Thanks for the question, Subbu. We love new modalities for a lot of reasons. And I'll try to just mention maybe a couple of them. The first one is when you look at the current pipeline of pharmaceutical company, I mean, today, almost half of the products they have in their pipeline are coming from new modalities. And obviously, it makes the life of the global head of R&D from those big pharma companies very complex because we are probably in the past, they were dealing with three or four different types of products. Now they have to deal with 10 to 15 different ones. So what do these guys need? They need a company that is capable to support them and support them with customized solutions, support them with agility and the ability to turn around a solution for the problem they are facing that they don't have a good solution for. And we think we're doing well here because we are indeed agile and we are faster probably than many others to develop and launch new products. And that's what probably those companies really appreciate from us. So that's really one side, I think, of the picture that is very important. There's a second one really about new modalities, the diversity that I also very interesting from the point of view, there is not one solution that fits it all. I mean, you have to really be capable to adjust the way you look at manufacturing from a totally different angle, because if you compare manufacturing of a CAR-T product on one side, manufacturing of a valve vector on the other side and our ADCs and so on, and so on, I mean, they all have totally different requirements. And here again, you need to be capable to sit around the table and support the people the right way. And I think we all know, like from a therapeutical point of view, there are beautiful stuff happening and that's probably in the next 5 to 10 years, a lot of these diseases that are not being cured today will be cured by some of these new modalities. So we are absolutely very, very excited about it. And we think we are bringing a lot of good solutions to our customers on that side.

Operator

Operator

The next question comes from Justin Bowers with Deutsche Bank.

Justin Bowers

Analyst · Deutsche Bank

Hi, good morning, everyone. Olivier, can you expand upon the strength you saw in hardware during the quarter? Did that include any platform wins, either expansions or new placements there? And maybe talk about just which franchises you saw some of the strength in.

Olivier Loeillot

Analyst · Deutsche Bank

Yes, no, absolutely. I mean, so on hardware, I talked already about ARTeSYN and about the large scale system. Don't forget that also a big part of our ATF business consists in system as well. So in hardware. So it's across the board. I mean, as we mentioned, as you heard, ATF did very well in 2024. And obviously, the hardware part of ATF did very well in 2024 as well. And then on the rest, which is more of the filtration and chromatography systems, which is now today very, very much depending on the ARTeSYN Portfolio we acquired several years ago. Again, the reason why we are very successful here is because we've got very differentiating solutions with very high technology on one side and combination with PAT technologies on the other side. And people really like them. I mean, people probably didn't know us much two years ago. Now they start to know us much more. And with the key account management focus we had, particularly at some of these big pharma, we are starting to get platform. I mean, I want to say three or four big pharma companies have decided to start platforming us last year for their CFF manufacturing solutions. So that's definitely for us a big, big win we had in 2024. And then the last piece, particularly ARTeSYN Portfolio, is there is full stickiness of consumable, meaning like once you install an RF system, you're going to get a flow of single-use consumable sales for the next five to 10 years. And that's going to be obviously a very significant tailwind for our business for the next few years as well here.

Justin Bowers

Analyst · Deutsche Bank

Thank you. And then one quick follow up just on the strength ex and APAC ex-China and some of the growth initiatives there. Is that currently being driven by CDMO or is the participation there in pharma and biotech as well? And where are you focusing the growth?

Olivier Loeillot

Analyst · Deutsche Bank

Yes. I don't know exactly to tell you the truth, Justin. I would like to say that, I mean, if you think about a country like Korea, obviously you've got both the biggest CDMO in the world, and you've got probably one of the biggest biosimilar companies in the world. So if you think about a country like that, and I know I'm only picking up two companies down there, but you would say it's probably pretty balanced between the two. I don't have the exact number or something we would need to check. But back to the number themselves, I mean, you're right, like Asia did very well for us in 2024, excluding China. In fact, APAC for the full year grew 12%, excluding China. In terms of sales and in terms of orders, we grew around 16%. So it was a really good year for us. I mentioned Korea, which is obviously a big area of focus for us and others as well. But people shouldn't forget countries like Japan as well, who have been rebounding very nicely now for the last two to three years because the government after COVID has decided to invest a lot of money. And then Singapore, which is kind of benefiting from the side of the softer China, where people are back to invest a lot in Singapore as well. So yes, Asia outside of China did very well for us in 2024, and we've got big hopes that growth is going to accelerate in 2025 and beyond. And then on China, we think we've reached the bottom. I mean, our orders in the second half of 2024 were slightly higher than our orders in the first half. So we are hoping we've reached the bottom and we are going to be back to growth mode somewhere probably around the second half of 2025.

Operator

Operator

The next question comes from Paul Knight with KeyBanc.

Paul Knight

Analyst · KeyBanc

Thanks so much for the question. Regarding the recovery in CDMOs, what do you think is happening there? Is it they're getting past making material for COVID or they're seeing better financing from biotech? It's been odd that they've been really bullish, but now we're starting to see their orders for companies like Repligen. If you could comment on that first. Thanks.

Olivier Loeillot

Analyst · KeyBanc

Yes, no, Paul, absolutely. And that's obviously a question we're asking ourselves every day. I'll start with the big CDMOs. I mean, the big CDMOs, what their obsession is to get those very large, long term, 10 year supply contract with big pharma company on commercial drugs. And I mean, if you look at the top two, if not maybe the top three or four, I mean, they've announced some of these very big deals over the last several months. And I mean, some of these have been the highest they've ever signed. And when you are one of these big CDMOs, I mean this is giving you a lot of clarity, a lot of confidence over the next five to 10 years, because you are kind of secured with the base business you need to have to be successful for the next five to 10 years. And then you can start to do cool things, which is to grab maybe smaller products, earlier phase products that are going to be the products for the future. So I think the big guys are definitely in very good shape today. What I found interesting when we looked at our numbers was to see that the tail end, the smaller CDMOs, the Tier 2, as we call them, did very well for us for the last two quarters. And here you would say it's probably because they are also benefiting from some of the tail end also the big pharma products that are not a good fit to the larger CDMOs, because they are probably smaller in size. But also, I think the BIOSECURE Act definitely had some impact for some of the Tier 2 CDMO, particularly in the US, where we know some of these guys have benefited from it. In terms of the funding of small biotech, I mean, that's something we're still looking at very carefully. There was some improvement last year, I think the total funding was up about 45% versus 2023. What we didn't like too much was a trend where quarter by quarter funding went down, I mean, from $18 billion in quarter one to $15 billion in quarter two, and then $12 billion in quarter three and quarter four. And I want to say January was pretty weak as well, at around $3 billion to $3.5 billion. So that is something we still need to watch. If there is one segment that we think has not really recovered completely yet, it's really those small biotech.

Paul Knight

Analyst · KeyBanc

And then lastly, I know you have a lot of hollow fiber capacity. What do you plan to do there? Could you use that capacity to somehow get into the GLP-1 market? Or is that kind of just still in R&D?

Olivier Loeillot

Analyst · KeyBanc

Yes, no, that's a really good question. I mean, among a lot of stuff we want to focus on, one of them is to make sure we spend more time with our commercial team to get designing with some of these very differentiating products we have. And it's not only hollow fiber, it's several others as well. So that's an initiative. And when you hear about the fact we're investing more into sales, I mean, that's definitely one of the areas where we want to get more of these application specialists in our team so that we can spend more time designing those beautiful technologies we have that we know are going to get more success in the future. And hollow fiber is one of them, it's not the only one. Maybe one more question and yes.

Operator

Operator

Our last question today will come from Doug Schenkel with Wolfe Research.

Doug Schenkel

Analyst · Wolfe Research

Good morning, and thank you for taking my questions. There was an earlier question about your yearend instrument performance versus peers. And we're always hesitant to make calls about share shifts in an increasingly sticky market. That said, I am wondering if you are seeing any pickup in customers swapping out existing lines for your products in what seems to be an environment where, at least based on what we're hearing from others, it seems like the build out of new lines is still muted. So I'm wondering if that's some of what's different about what's going on with you versus peers. And then just very quickly on guidance and really just pacing, given the order strength in Q4 and given how short it is now for you to, or how not long it takes for you to fulfill orders, it does seem like Q1, the commentary would seemingly derisk things fairly substantially. I just want to make sure we're not missing anything in terms of the size of the orders, the duration of the orders, because it certainly seems like the bias would be to the upside given how you guided and the strength of orders into yearend. Thank you.

Olivier Loeillot

Analyst · Wolfe Research

Yes, sure. Well, I mean, for the first part of the question, I want to start by saying we're a very small actor on the hardware market. I mean, let's be honest, we are coming from a very low level. So obviously, when you're coming with new products on this very significant market, and you're bringing beautiful products, and you don't have a lot of market share, at the beginning of the day, you can really only win unless you're not doing the job properly. So that's probably why we're seeing that market from a bit of a different angle. This being said, yes, we've had a lot of great wins over the last several quarters, and because we do have great products, again, combined with the right PAT technology. So we are definitely gaining market share. I mentioned earlier, what we like is we start to get platform at some of these big pharma companies who started buying one, two, three systems maybe a couple of years ago, and now who are buying one new system every other month. And that's something we are really very happy about, because it means not only, they like the product we launched a few years ago, but once they've been starting to use it, they realize it's a big differentiator. So that's definitely where we see traction. But again, we're coming from a low point in terms of having very low market share. And then just to answer the latter part of your question, yes, you're right. I mean, typically, hardware has a lead time of three to six months. So you would assume like the orders you have in your plan for sales in quarter one, you receive them already in the previous quarter. That's absolutely fair, which is different from consumable, where you can get consumable order in the quarter to deliver in the same quarter. So with this, I think we'll wrap it up for today. So thank you for joining the call. We really appreciate the time you took. We are all excited about the year to come, and we'll talk soon together again. Thank you so much. Cheers.

Operator

Operator

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