Good day, ladies and gentlemen. And welcome to Repligen Corporation's first quarter of 2025 earnings call. My name is Dovan. And I will be your coordinator. All participants will be in the listen-only mode. Should you need assistance, please signal a conference specialist by pressing the star key followed by zero. Please note that there will be a question and answer session following the company's formal remarks. The company would like to note that there will be a limited time frame for Q&A. And as such, management kindly requests that each individual ask one question to try to accommodate all. I would like to turn the call over to your host for today's call, Jacob Johnson, Vice President of Investor Relations for Repligen.

Thank you, operator. Welcome to our first quarter of 2025 report. On this call, we will cover business highlights and financial performance for the three-month period ending March 31, 2025, and we'll provide financial guidance for the full year 2025. Joining us on the call today are Repligen's President and Chief Executive Officer, Olivier Loeillot, and our Chief Financial Officer, Jason Garland. As a reminder, the forward-looking statements that we make during this call, including those regarding business goals and expectations for the financial performance of the company, are subject to risks and uncertainties that may cause actual events or results to differ. Additional information concerning the risk related to our business is included in our quarterly reports on Form 10-Q, our annual report on Form 10-K, for the year ended December 31, 2024, and our current reports including the Form 8-K that we are filing today, and other filings that we make with the Securities and Exchange Commission. Today's comments reflect management's current views which could change as a result of new information, future events, or otherwise. The company does not obligate or commit itself to update forward-looking statements except as required by law. During this call, we are providing non-GAAP financial results and guidance unless otherwise noted. Reconciliations of GAAP to non-GAAP financial measures are included in the press release that we issued this morning, which is posted on Repligen's website and on sec.gov. Adjusted non-GAAP figures in today's report include the following: non-COVID and organic revenue and/or revenue growth, cost of goods sold, gross profit, and gross margin. Operating expenses including R&D and SG&A, income from operations and operating margin, tax rate on pre-tax income, net income, diluted earnings per share, EBITDA, adjusted EBITDA, adjusted EBITDA margins. These adjusted financial measures should not be viewed as an alternative to GAAP measures but are intended to best reflect the performance of our ongoing operations. Now, I'll turn the call over to Olivier.

Thank you, and welcome to Repligen, Jacob. Good morning, everyone, and welcome to our 2025 first quarter call. Before jumping into our overall business performance, I want to spend a few minutes on the current environment. It's obviously a very dynamic macro backdrop with new headlines emerging every day. As you saw in our release, we had a very good first quarter and are encouraged by the underlying trends and opportunities in our business. We acknowledge macro uncertainties exist and are working to adapt to an evolving environment. As it pertains to tariffs, at this point in time, we see a limited net impact on our EPS. Given the strength we have been seeing in orders for the last few quarters, and with Q1 2025 orders slightly above Q4 2024, our organic full-year 2025 guidance remains unchanged. This does not include specific impacts from tariffs. As it pertains to tariffs, I would first highlight that the majority of our manufacturing is in the US. In fact, more than 90% of our US revenue is manufactured in the US, or currently exempt from tariffs. In an effort to frame the potential impact of tariffs, we estimate that approximately 10% of our cost of goods sold are from raw materials directly sourced outside of the manufacturing region. In addition, we estimate a low single-digit percentage of our revenue could be subject to US tariffs. As it relates to Europe and Asia ex-China, this is where we could potentially have greater exposure in the case of retaliation as revenue manufactured in the US for these regions represents about a quarter of our total revenue. Based on the most recent proposal we have seen, tariffs would not apply to a sizable majority of these revenues. We are working to mitigate tariff impacts by leveraging…

Thank you, Olivier, and good morning, everyone. Today, we are reporting our financial results for the first quarter of 2025 and providing an update to our financial guidance for the full year. Unless otherwise mentioned, all financial measures discussed for As shared in our press release this morning, we delivered first-quarter revenue of $169 million. This exceeded our expectations of a sequential decline from the fourth quarter despite a $2 million or a 1.5-point headwind from foreign exchange. This is a reported increase of 10% for the first quarter. We were up 11% on an organic basis which excludes the impact of acquisitions in currency and up 14% on an organic non-COVID basis which we believe best reflects our underlying great performance in the quarter. Acquisitions contributed approximately one point of the reported growth. As Olivier shared color on our product franchise performance, I'll provide more detail on the performance across our global regions. Starting with quarterly revenue, North America represented 50% of our total Europe represented 35%, and Asia Pacific and the rest of the world represented 15%. North America and Europe were both up 13% and Asia excluding China was equally strong with 12% growth. China was down significantly and as Olivier mentioned earlier now represents about 2% of our total business. China remains a region with unique challenges but given our relatively small exposure to the region and the strength we are seeing elsewhere, we believe we can largely offset China-related headwinds. For orders, North America and Europe were the regions that drove our growth in the quarter. Transitioning to profit margins, we are very pleased with our performance in the first quarter when the adjusted gross profit of $91 million and delivering 53.7% adjusted gross margin. This is up nearly 450 basis points versus last year…

We will now begin the question and answer session. To ask a question, you may press star then one on your telephone keypad. If you are using a speakerphone, please pick up your handset before pressing the keys. At any time your question has been addressed and you would like to withdraw your question, please press star, then two. At this time, we will pause momentarily to assemble our roster. The first question comes from Rachel Vatnsdal with JPMorgan. Please go ahead.

Perfect. Good morning. Thanks so much for taking the questions. And quickly, just wanted to say, Sondra, congratulations on the retirement. It's been great working with you. And, Jacob, looking forward to working with you on this side as well. So maybe just digging into it. First question, I wanted to ask on the CDMO order trends that you guys saw in the quarter. You mentioned that CDMO orders grew 40%. One question we're just getting right now is on the tariff dynamic. Did the tariffs impact any element that pull forward in your order book this quarter? Especially with some of those large CDMO customers? And then just given how solid that order number was, can you walk us through what were some of the key products that drove that solid order? And remind us where are you guys at in terms of ATF adoption within those CDMO customers as well?

Good morning, Rachel. Great questions. So I'll start by saying we've not seen really any customer trying to accelerate orders in the quarter. I mean, not a single one. In fact, and that includes all CDMOs. You're right. We had a really great order intake growth from CDMO in Q1. The good news, it was really across the board. It was not only the large one, but it was also the smaller one. And also in terms of product line, it was very much across the entire portfolio. I mean, you felt like with a very strong performance on the Opus side, particularly with orders up more than 50%. As you know, CDMOs are our primary customers on the Opus side, and we've seen really big orders coming from those guys in the first quarter. So no real trend of accelerating anything. I don't think I've seen a single example here. And as far as ATF is concerned, we mentioned previously that nine of the top ten CDMOs are already using ATF, and the number ten is just in the process of implementing it as well. So, obviously, that's another big driver of the CDMO growth we've seen in Q1, which is on the ATF consumable, which otherwise did very well in Q1 as well.

Great. And then on my follow-up, I just wanted to dig into tariff dynamics. So you mentioned really minimal impact to EPS, but just on the top line, you said that you could have up to low single-digit percent of revenue exposure. So can you walk us through the various buckets of offsets that you guys are seeing on that? How much of this is just gonna be incremental pricing pass-through? And how much price do you really think that you can pass through in this environment? And then things like some of the manufacturing offsets as well help us bucket those different ways that you're mitigating the impact there. Thanks.

Yeah, Rachel. So just to address that, I do think we believe that it's probably less than 1% sales increase that we would have from tariffs. And that would come through surcharges. Right? Surcharges mostly that we would pass a one-for-one in terms of whenever we were incurring those costs to the customer. The other point there, there could be price increases. That's gonna be more of a how do we offset the inflation that we see on raw materials that we're purchasing. And so that ends up in the top line as well. But overall, between those two, we think that it's probably around that 1% of sales increase. That then would translate probably less than 50 bps of gross margin pressure. Because effectively you're taking that sales without any cost and it's a full pass-through. But on a dollar basis, we see same kind of flat, and that's why we said there was minimal EPS expenses. We absolutely are looking at our manufacturing footprint. Like Olivier mentioned, 90% of what we sell in the US is either manufactured or exempt from duties. And so we got really strong coverage within there. We've also been very clear that our bigger exposure is primarily in Europe, that's where we would have a bigger exposure. Right now, that's not the case. The far majority of what we're selling into Europe is not subject to that. So that's the one that we would watch and take other actions on, but I know there's some questions why we didn't put in the guide. Maybe I just addressed that now. I think for us, there's just tariffs as well as FX really are moving targets. And so that's why we didn't specifically put them in the guide. But also we've been trying to be very clear and transparent about some sensitivities around that and try to put a framework to this dialogue. So certainly, if things stabilize, we will. And we'll move forward from there.

The next question is from Dan Arias with Stifel. Please go ahead.

Hi. Good morning, guys. Thanks for the question. Olivier, I wanted to ask about emerging modalities and just how you feel about things there. Obviously, some high-profile news on certain drugs and then certain folks at the FDA, which has been less good. But it feels like the industry activity is still in a good place just when you think about active trials, etcetera. So you mentioned new modalities were up. You alluded to some of the challenges. When you combine all of that high level and ground level stuff that puts in the takes there, you see cell and gene therapy on a trajectory that's accelerating, decelerating, or flat this year. And when you think about the things taking place at the FDA, you talk to your partner companies, are you sensing any disruption from some of the changes that are taking place there that would rise to the level of being an issue for you guys? Thanks.

Yeah. No. Good morning, Dan. A lot of good questions. First of all, you're right. New modalities played out really well for us in Q1. Our sales were up mid-single digit. Our orders were up more than 20%. Again, so which was very encouraging. But we're obviously monitoring all of the headlines. Maybe one thing to mention here is our biggest new modality customer represents less than 3% of our total revenue in 2024. And so I know we get asked a lot of questions about that. That's probably something very important to mention. So as far as the overall environment is concerned, while there could be some short-term challenges, we remain very optimistic about the mid to long term. And so far, talking about changes at the FDA, we have not really heard any of our customers telling us at this stage they are slowing down or they are even canceling for some specific trials that they were running on new modalities. So we remain very optimistic. Again, we are watching the news like anybody else, but so far, we don't see any reason to be worried about the future of new modalities at all, Daniel.

Okay. Thanks much.

We have our next question from Puneet Souda with Leerink Partners. Please go ahead.

Yeah. Hi. Olivier and Jason. Thanks for the questions. And, Jacob, I'm really looking forward to working with you. On the growth side, if I could ask, I mean, obviously, the strong growth in the quarter. Orders also strong across different end markets. And customers and modalities. But just could you elaborate if your mix of clinical versus commercial is changing as a result as you're getting spec into the commercial, maybe things are moving from phase two to phase three and maybe into commercial. Maybe could you elaborate a bit on that? Because the growth, you know, I think the question here is, you know, sort of how sustainable is this growth? And given the questions we are getting on the clinical trials and the momentum on clinical trials versus what we're seeing in the commercial side of the business.

Yeah. Hey. Good morning, Puneet. So great question. We are still at 65/35 a year later. So in principle, you would say, oh, nothing has changed. But in fact, a lot has changed between 2024 and 2025 because as you know, last year, we had this $30 plus million US dollar headwind coming from protein, and all of this was considered to be going into commercial drugs because that was mostly the OEM business we had with the two big guys. So considering what 65/35, it means that we have onboarded another $30 plus million US dollar of business going into commercial drugs. So if nothing would have changed on the protein side, our split would be today 60/40. Yeah. So, yeah, I think I mentioned in previous calls that's a direct we're gonna be going to for anywhere between three to five points of increase of commercial versus clinical probably during the next several years. So it's fair to say, like, probably four to five years down the road, we should be around 50/50, something like that.

Got it. Okay. Helpful. And then on the 908 Devices acquisition, obviously, you have done well with the PAT technologies. But CTech, soloVP, solo VPX. Just trying to understand, you know, how are you thinking about the commercial LAMP here? What is needed in sales and marketing in order to accelerate a product such as Revel into the marketplace? And what are some of the cost efforts that you're taking to sort of right-size the business while driving growth?

Yeah. So first of all, I start by saying the integration is moving exactly as scheduled. We have spent quite a bit of time to make sure we have the two teams, CTech plus 908 team working together very closely. In fact, we are onboarding a leader that will have the overview of both businesses together because we feel it's gonna be very important indeed to generate as many synergies as possible. And if I think about synergies, it's particularly on the R&D side. I mean, you know by now, there's a way we've been handling a lot of our acquisition is to not only really develop further the products those companies had in their portfolio, but really taking advantage of the rest of the portfolio. We have to leverage across the board the technologies from both sides. So we got a huge focus on R&D in particular. Starting by adding more features to some of the products coming out of 908 and Robo is a good example where we're gonna launch a new version within the next quarter or so but also adding more features to Maverick on the Raman side and then making sure, like, we leverage the strong technical team we got with this acquisition to help us also accelerating innovation on the CTech side, partly with the mid IR technology where quite the right from a few years ago. So a lot of work happening on the R&D side. And then on the commercial side, already the two teams are being incentivized to generate leads for the other part. And it's fair to assume, like, those two teams are really gonna be working very closely with each other. And then finally, from an operation point of view, we are just finalizing the move from the Massachusetts site to our own site here in Malboro. For the manufacturing of the vast majority of the equipment from 908 and where we are looking at all the potential synergies for the future to improve the cost base here as well.

Got it. Okay. Thank you.

Our next question comes from Matt Larew with William Blair. Please go ahead.

Hey, guys. Thanks for the questions. This is Jacob on for Matt. So just wanna talk a little bit more about trends by customer type, maybe just on small biotech specifically. I didn't hear much about that group in the prepared remarks. But I think last quarter to you said orders for this group grew 10% sequentially, perhaps, you know, signaling a leading indicator for return to growth later in the year. However, you know, lots changed from a macro standpoint since you last reported, and lots changing by the day and minute. So maybe if you just, you know, provide some incremental color on you're seeing with this customer group, what did orders look like in the quarter, are you still optimistic this group will return to this table despite the macro?

Yep. Jacob. So if you look at all customer segments, obviously, pharma did extremely well, record quarter for us. And when I say pharma, big pharma, CDMO did very well in terms of orders with orders up more than 40%. The only segment reason that didn't do very well for us in Q1 was small biotech, and not so much from an order point of view where orders were pretty flat comparable to last year, but from a sales point of view where the sales to emerging market went down a high single digit. So yeah, we are still watching that segment carefully. It's becoming smaller and smaller for us. It's less than 10% of our total business, so it's not very material. But as I mentioned in earlier calls, I mean, it's a segment everybody is watching because the health of that segment is important for the future health of the ecosystem. And the best indicator is biotech funding, which unfortunately went down significantly in Q1. If you remember the trend last year, it went from $18 billion in Q1 to $15 billion and then $12 billion towards the end of the year. And then Q1 of this year was only at $8 billion. So for me, biotech funding is not doing very well. So something everybody is watching carefully because we want to see that recovering faster than it does right now for sure.

The next question comes from Justin Bowers with Deutsche Bank. Please go ahead.

Hi. Good morning, everyone. Olivier, we've seen a lot of announcements from large biopharma over the last few weeks around, you know, onshoring or increasing CapEx plans. Just curious what your thoughts are on those announcements as it relates to the longer-term outlook and whether any of those announcements are leading to early discussions for you at this point.

Hey. Good morning, Justin. Yeah. No. Obviously, being an American company with the majority of manufacturing, we were watching all of these announcements in a very positive manner because obviously, we think this means extra business coming for all of the bioprocessing industry in the upcoming few years and particularly certainly, for those companies who have got a very strong installed base in the US. And so and then most of these customers that have been making announcements are companies we've been working with very extensively. And as you know, we've been focusing a lot on tier during the last couple of years. And today, we most of this company, we are selling across our entire portfolio. So we see that as a very positive tailwind for the next several years, and there are already a few discussions happening on the different front here.

Thanks. And, Jason, just a quick one. How are you thinking about the margin margin cadence for the rest of the year?

For gross margin, so we, you know, we highlighted the strength we had in the first quarter, but it was certainly helped by the mix of strong proteins. And so we see that as the high point and then kinda going down. You know, if you look at some of the implied guide for the rest of the year, you're kinda sitting at a 52-ish, maybe a little bit more, and that will, you know, kinda maybe pick up a little bit through the course of the quarters. But, again, we are really happy with the performance we had. You know, even if you take out the mix, we had strong productivity, good volume leverage. You know, the back half of that of the year or even the third second, third, and fourth quarter, we'll see mix put the other way. So we actually kinda go to this hole we have to dig out of, and, again, are able to do that through more productivity and volume leverage. So really happy with the performance versus we're driving here at the gross margin level.

Thanks.

Our next question comes from Subbu Nambi with Guggenheim Securities. Please go ahead.

Hey, guys. Thank you for taking my questions. Anton, we'll miss you, Jacob. We are looking forward to working with you. My question is, because of the pharma tariffs, some pharma companies are talking about cutting their R&D. This is likely to impact the clinical pipeline of the drugs. How much of the guide today is driven by growth in the clinical pipeline for Repligen? Or is this a wrong way to think about it for 2025? Rather more long term?

Hey. Good morning, Subbu. Yeah. No. I mean, I think I mentioned earlier, we've not seen a single class customer telling us, hey, bad news. We've decided to put that program on hold, or we're gonna delay that specific clinical trial. In fact, I think clinical trial starts have been increasing nicely in Q1. So where biotech funding was not good, clinical trial start was pretty good in Q1. So we've not seen any of these customers telling us anything like that, and I know we are talking a lot about the US situation, obviously. I mean, half of our business is still outside of the US as well where everything is running absolutely totally normally as well. So we don't really have any concern for the time being. And also, when you hear about the commission McCarrie who recently announced, like, they would like to speed up approval of drug and so on. I know this is just an announcement, but this might just be another tailwind for the industry. So really nothing we've heard from any of our customers so far that it makes us feel particularly worried at this stage, Subbu.

Thank you for that, Olivier. And then on NIH, you don't have a lot of exposure, but it will be good to hear if there is any impact of these NIH funding changes that are contemplated in the guidance, or is this something that you think could have a longer-term impact on growth?

Yeah. No. It's a bit similar to the discussion we had earlier on small biotechs. For us, I mean, business that is NIH dependent is less than 1%. So it's almost a de minimis. But at the end of the day, yes. You want to see NIH funding increasing because in the longer term, I mean, you want to see a new product development. No later than this morning, I was seeing statistics showing the number of products on the development in each country around the world, and it's interesting to see, like, particularly in Asia, in countries like China, in countries like South Korea, I mean, the number of products under development is increasing tremendously. So we want to see a strong NIH, a strong product development environment here in the US as well because that's gonna be important for the ecosystem in the mid to long term for sure.

Thank you, guys.

The next question comes from Brendan Smith with TD Cowen. Please go ahead.

Great. Thanks for taking the questions guys, and congrats on the strong quarter. Maybe to give you acting a bit off of an earlier question, I wanted to actually ask how you're thinking about and if you expect any impact specifically from FDA's recent guidance looking to phase out animal testing for biologics. I guess I'm really just wondering if there's anything of note you've heard from any customers or thoughts on how some of this might play out for your customers and potential timing for some of the impacts just given all the recent staffing because of the agency?

Hey, Brandon. No. I have not heard anything at all on that side, to be honest with you. Maybe I've heard a few people suggesting this might accelerate somehow some of the clinical move from one phase to the other, but nothing really tangible at this stage.

Okay. Got it. And then maybe just quickly kind of regarding your manufacturing in US versus next US how I guess, I'm wondering how much flexibility you have to shift any of that particular segments more than others, I guess I'm really just wondering if there are any levers you can pull there should the EU tariff situation maybe materialize a bit more concretely.

Yeah. So the answer is yes. There is leverage. I mean, we've got multiple sites both in the US but also in Europe. If you look at our portfolio today for several of our product lines, we already have dual manufacturing sites that include the Opus columns, that include the fluid management, that include to a large extent our systems as well. So for the remainder of the portfolio, we are indeed looking at opportunities to have dual siding manufacturing in the future indeed in case the tariff situation would degrade over the next few quarters. So, absolutely, we're looking at that and we could definitely leverage our strong installed base around the world at this stage.

K. Great. Thank you.

The next question comes from Doug Schenkel with Wolfe Research.

Hey. Good morning. Thank you for taking the question. Questions. So one on guidance and then one on positioning outside the U.S. Given the current policy situation. So on guidance, just a clarification. You are now guiding organic Actually, it says you are guiding non-COVID revenue growth to 11.5 to 15.5%. That's the growth rate you've guided to. Last quarter, you guided non-COVID organic revenue growth to 10 to 14%. So I'm just trying to see if that's apples to apples. And if that is organic to organic specifically. Because if so, that would seem to be a positive sign on your view of fundamental non-COVID demand. So I just wanna clarify that. We've got a couple of questions there. So that's my first question. The second is you know, really kind of acknowledging something that you talked about last quarter where you talked about adding some roles in Asia. I'm wondering if you'd be willing to speak a little bit more about, you know, where you've been adding, what the follow-through has been, And, you know, really, I'm focused on this because it could turn out that this is really well-timed as it may really improve your positioning to take advantage of customer movement out of China into other Asian locations. Thank you.

Excellent, Doug. So let me start with the second question on Asia, and then Jason will take care of the first question. So yes, you're right. I've been talking quite a bit about Asia. I spent quite a bit of time living in the region over there. So it's a region that I know has got huge potential for us. But, obviously, we've gone through a lot of changes over the last several years. So let me start with China, which China obviously has not been doing very well for us now for the last few quarters. We just onboarded a global Asia leader who were just relocated to China, Singapore and gentlemen, who just relocated to China and who is really just building our new strategy for China because the way to win in China in the upcoming few hours is gonna be totally different from the way you were winning before COVID. We also just hired a leader to run China being the GM reporting set global Asia leader. We are literally gonna do a report out of the Strath in the next few weeks. And we've got very ambitious plan because I'm convinced the China market will start growing again very nicely probably from 2026 onwards, and we want to be a big player there. Outside of China, I mean, the rest has been doing very well for us. And, obviously, everybody knows how dynamic a country like South Korea is, but also to a large extent Japan in the most recent past as well. So here, again, as well, we are working on very specific strategies and we have got a lot of ambition to become much bigger in those two countries in particular. I would just add Singapore as well, because Singapore is also a very, very important market for us then. But I'll hand over back to Jason on the guidance question here.

You know, it's a good question. It is a new metric. And we did it because we think it's a better view of how we're performing. The last this one is this quarter, it's fully organic. Meaning and the last one was not. Meaning, last quarter, we excluded M&A in COVID. We didn't exclude the impact of FX. And now this quarter, we are excluding the impact of FX. So again, I know there's a lot of different nomenclatures. Organic for us is the exclusion of both M&A and FX. So given just the FX volatility that we're seeing you know, we had, you know, $2 million of pressure almost a point and a half of pressure at the growth rate level in the quarter. You know, we felt like taking acquisition or sorry, FX impact in addition to acquisition would be the most sort of apples to apples view of our performance. And so that is not a change in overall what we looked at, from a performance, but we thought we'd clarify that.

Did that answer your question then?

I think so. And I know we can follow-up after, but the bottom line is you know, strong momentum, but really this isn't a change in view, just a continuation in view in terms of how you guys are seeing the business today. At least from an organic standpoint. Is that fair, Jason?

Yeah. No change. Exactly. No change to organic, meaning no FX impact. In acquisition and taking out, you know, COVID. All that's the same. We're trying to isolate. There's so many moving pieces, right, in terms of impact. You know, we're gonna have to talk at x tariffs, x, you know, this and that. Right? And so we're gonna really isolate it down.

Or just a few moving parts.

Okay. Thank you very much.

Alright.

Thanks for the question. Thanks, Doug.

The next question is from Matt Stanton with Jefferies. Please go ahead.

Thanks. Maybe one on Opus. I think Olivier talked about larger scale columns driving some demand here in 1Q as well as really nice order strength. I think you set up 50% in the quarter. And talked about some adoption large pharma that's traditionally been more opportunity what's driving the uptick at large pharma? Why now? Obviously, Opus has been around for a while, and just the durability of these demand in order trends as they maybe look to adopt it a bit more over time. Thank you.

Yeah. So good question. Morning, Matt. So I'll start maybe with the scale because that was your first question here. We've indeed seen a shift toward larger scale Opus columns in Q1, which we like quite a bit, obviously. And we try to understand where this might be coming from. I mean, as you know very well, there has been a lot of single-use manufacturing plans being built over the last several years and particularly at the 2000 liters scale, which was the highest scale before 5000 liter came recently. So a lot of these plants really start to run at full speed during maybe the last one or two years. And for this type of large-scale single-use manufacturing plant, you want to use single-use columns, you want to use pre-packed columns, so we think that's probably one of the reasons why we've seen a shift towards more of the larger scale Opus column over the last quarter or so. And then in terms of new the new the pharma businesses, we managed to grab I mean, as you know, CDMOs, they love Opus columns because for them, it's all about having the ability to switch very fast from one customer to the other and having those pre-packed columns on the shelves enable them to do that very fast. So for us, we've been really pushing more on the pharma side because we know, like, ZipGuys were probably a bit more reluctant to use prepack column, and we had the two pharma wins in Q1 that we think are gonna be staying now for the next several quarters, and one of them we being with a really big pharma company. So that was a very significant win for us. So we were hoping to see more coming. We've got a big commercial effort focused on pharma for prepack column right now.

Thanks. And maybe just one on the innovation engine. You know, you launched the first resin autotante few months ago. Just any early feedback there. And then if you just remind us of the pipeline there, I think you're hopeful to get some other product out from Tonty once it was integrated this year. And then in Meta Nova, it sounds like early indications on the new mixer launch a few weeks ago going well on demos and orders. Can you also just remind me us of the opportunity around the bag strategy with MetaNova as you get some of those new mixers out and to tag on the consumables on the back end. Thank you.

Yep. So starting with the resins, I mean, we are really delighted, how Q1 played out. And you might remember I mentioned how strategy was not to become really very independent and then have all this in our hands for the future, and we start to collect the fruits of it. I mean, I start by just clarifying, like, the collaboration with Pure is doing very well. We are delighted to work hand in hand. We had multiple meetings with customers together, and we have a lot of great traction. And that's for monoclonal antibody. And outside of monoclonal, indeed, where we are developing and launching our own products, one of the reasons why Q1 really outperformed across the board was because of some of our own chromatography resin that were really a big success for us in Q1. Including the double-stranded RNA, which launch has been doing very well as well. So really great traction. We're gonna launch at least two, if not three new resins over the next few quarters. So we're extremely optimistic about the traction we have on the protein slash resin side. And then in terms of the mixes, yes, you're right. We just launched our single-use mix at Informix beginning of April. A lot of very positive feedback. Again, it's not like a me-too product because there are so many companies in the field. We are really using the technology from MeteNova, which we know because we got that feedback on the stainless steel side, it's considered to be the best mixing technology by far. So now people who have been using our mixers with stainless steel technology are delighted to see us coming with single-view solutions because I know the quality of mixing is just better than anything else on the market today. So we are just going to demo those equipment probably in Q2 and Q3. And we'll start collecting orders towards the second half of this year, and we should start to see sales happening in 2026 and beyond here.

Perfect. Thank you.

The next question is from Dan Leonard with UBS. Go ahead.

Thanks very much. My first question is a quick cleanup. Is it possible to quantify the timing benefits in proteins in the quarter?

The benefit on what then?

Yeah. You mentioned, Jason, that there was a timing that contributed to your strong year-on-year growth in protein. So I was curious if you can quantify the size of whatever moved into Q1 that you weren't expecting.

No. No. No. And it was upside to the quarter from our expectation, but we'll see that sort of unwind through the course of the year, if you will. And that's why we end up with the same overall growth rate expectation for proteins for the year.

Yeah. Guidance 10 to 15% for the full year on protein, Dan. So no.

Okay. And at a higher level, you know, Olivier, how would you characterize your visibility nowadays now that you've got a couple quarters of double-digit growth under your belt? How confident are you that this demand is run rate versus any restocking dynamic?

Yeah. No. Of course, as you know, we are tracking a lot of different parameters to really have maximum visibility. Well, one I didn't mention so far is our funnel of opportunities are both 50% ended up being higher by 30% at the end Q1 than a year ago. And that's a very big indicator for us because, you know, we typically have about four months of backlog in the pockets. So you want to have a very strong funnel as well. So this is what kind of gets you very confident about growth coming for the next several quarters beyond the next two quarters. So we have all indicators look really good for us at this stage, and I think all of the initiatives we've taken commercially and from a product launch point of view are really coming to fruition right now, which is why we were very confident about the year.

Okay. Thank you.

Thank you.

We will now conclude our question and answer session. I would like to turn the conference back over to Olivier Loeillot, for any closing remarks.

Well, thank you everybody for joining us today. We are obviously very pleased with the start of 2025. I would like to really give a special thanks to our entire Repligen colleagues and team for helping deliver this very strong growth in Q1. As you all know, we are very focused on our strategic plan, and we look forward to speaking with everyone again very soon. Good day.

The conference has now concluded. Thank you for attending today's presentation. You may now disconnect.