Good day, and welcome to Rhythm Pharmaceuticals Fourth Quarter and Fiscal Year 2024 Earnings Conference Call. [Operator Instructions] As a reminder, this call may be recorded. I would now like to turn the call over to David Connolly, IR and Corporate Communications.

Thank you, Michelle. I'm Dave Connolly here at Rhythm Pharmaceuticals. For those of you participating on the conference call, our slides can be accessed and controlled by going to the Investors section of our website ir.rhythmtx.com. This morning, we issued our press release that provides our 2024 and full year 2024 financial results and a business update and that press release is available on our website. Our agenda is listed on Slide 2. On the call today are David Meeker, our Chairman, Chief Executive Officer and President; Jennifer Lee, Executive Vice President, Head of North America; Hunter Smith, Chief Financial Officer; and Yann Mazabraud, Executive Vice President, Head of International is on the line joining us from Europe. On Slide 3, I'll remind you that this call contains remarks concerning future expectations, plans and prospects, which constitute forward-looking statements. Actual results may differ materially from those indicated by these forward-looking statements as a result of various important factors, including those discussed in our most recent annual or quarterly reports on file with the SEC. In addition, any forward-looking statements represent our views of today and should not be relied upon as representing our views as of any subsequent dates. We specifically disclaim any obligation to update such statements. With that, I'll turn the call over to David Meeker, who will begin on Slide 5.

Thank you, Dave. Good morning, everybody. Thank you for joining. So we preannounced strong fourth quarter earnings in advance of the JPM conference. We are entering 2025 well capitalized, having recently raised $75 million in gross proceeds from our ATM program, which extends our cash run rate into 2027 through multiple inflection points, and we have completed enrollment in our Phase II daily oral bivamelagon study. We feel incredibly positive about how the opportunity in genetically driven impairments to the MC4R pathway signaling is evolving. As we have highlighted many times, ultra-rare disease opportunities like BBS, where there is a significant unmet medical need, a high percentage of undiagnosed patients and where the availability of a precision therapy can accelerate the number of patients getting to a diagnosis, these opportunities will continue to grow at a steady pace for a decade or longer. The U.S. opportunity is taking shape, and we will continue to expand internationally. We could build a business around the BBS opportunity alone. We are excited about the progress we are making with our next-generation compounds, bivamelagon, a once-daily oral pill and the weekly subcu injection RM-718. Now our goal of the next generation opportunity is not just to extend patent life but to actually make a better drug. Both products have robust activity in preclinical models and have no cardiovascular activity in the appropriate models. Both our MC1R sparing, so no hyperpigmentation and significantly more convenient, whether there is an opportunity to improve on efficacy remains to be seen. The bivamelagon Phase II study is fully enrolled this quarter, and we'll read out in the third quarter and the 718 program is beginning to enroll this quarter. So on Slide 7 is the now familiar design slide for a Phase III trial of setmelanotide in acquired…

Thank you, David. So 2024 was a solid year for IMCIVREE sales in the U.S. with consistent growth throughout the year. Over the years, we have fine-tuned our process to find patients, give them to an accurate diagnosis and ensure access to therapy. Once on therapy, we work with patients and their health care providers to support maintenance on therapy. More than 2 years and from launch, the system we have put in place is working and will also help future potential launches. New prescriptions received in the fourth quarter were consistent quarter-over-quarter. We are seeing continued success in approvals and reauthorizations and our tailored support to patients and families are enabling patients to receive a long-term benefit of maintaining on therapy. Within the fourth quarter, the increase in the number of patients on reimbursed therapy was attributable to a number of incrementally positive trends that when combined, added up to a strong growth. For example, in addition to the steady level of approvals for reimbursement from scripts received, we saw fewer discontinuations from patients who are on reimbursed therapy. Several switches from our free drug program to reimburse therapy and some later-stage appeal wins during the quarter. While none of the quarterly metrics in each of these categories, which stand out as a significant change on their own when taken together, it resulted in a strong quarter. Turning to Slide 12. In December, the FDA approved a label expansion for IMCIVREE to include children as young as 2 years of age with obesity due to BBS or POMC PCSK1 or LEPR deficiency. This approval sends a strong message that helps us differentiate the root cause and impact of these rare MC4R pathway diseases. With this insatiable hunger, most patients develop early onset obesity before the age of 5. Obesity…

Thank you, Jennifer. We are pleased with the growth in the international region for the fourth quarter of 2024 and for the year 2024. We have achieved access for IMCIVREE in more than 15 countries outside the U.S. for patients with POMC, BBS and HO through either a reimbursed access or named sales. Germany, with the BBS launch now well established in France, with paid early access programs for POMC, PBS and HO remain the main drivers for the region. In Germany, our BBS launch is steady and mirrors the consistent growth pattern of the U.S., and we continue to expand the number of centers treating BBS patients. France is also contributing with both the pre-EMA approval paid early access program for HO and the paid early access programs for POMC and BBS. We continue to receive positive feedback from the physicians treating patients in France under these programs, specifically, patients will either acquire or congenital hypothalamic obesity are responding well to setmelanotide. Also, like in the U.S., the marketing authorization for pediatric patients has led to reimbursement for patients as young as 2 years old in many countries, including the U.K., Spain and Italy. Today, we announced a new strategic partnership in Turkey, where there is a significant unmet need, the prevalence rates for rare diseases in general and POMC and BBS in our case, are greater than the rest of Europe, providing us an incremental growth opportunity. Our partner is Trispera Pharma Solutions an entity is very well known to us. We began working with them as a consultancy a few years back and recently formalized this new partnership. Trispera has deep experienced a relationship with rare disease community and MC4R pathway disease experts and Center of Excellence in Turkey. Last but not least, in Japan, we are beginning to build out operations in anticipation of success in acquired hypothalamic obesity with a significant unmet need and a prevalence per capita greater than in the U.S. or in Europe. Japan represents a major opportunity for Rhythm. Overall, 2024 has served a foundational year in expanding access to IMCIVREE across the international region, met with enthusiasm among scientific and medical experts, clinicians and patient advocacy groups and recognized IMCIVREE as a precision medicine for certain real neuroendocrine diseases. Hunter?

Thank you, Yann. Before getting into Q4 and the year-end financial results, I want to start with our balance sheet, beginning on Slide 17. Rhythm ended 2024 with $320.6 million in cash and cash equivalents. We raised gross proceeds of $75 million through the sale of approximately 1.3 million shares of common stock at a weighted average price of $56.30 under our at-the-market or ATM equity offering program during the fourth quarter of 2024 and continuing into January of 2025. The $320.6 million on cash on hand includes about $40 million of gross proceeds raised in Q4, but not the additional gross proceeds of $35 million raised in January. We expect this level of cash to be sufficient to fund planned operations into 2027, well past several meaningful milestones and data readouts, including the pivotal Phase III data readout and acquired hypothalamic obesity as well as the data readouts for both the Phase II trial of bivamelagon and HO and the Phase I Part C study of RM-718 in HO. We also anticipate data from the single site Prader-Willi trial as well as data from the Phase III M&A trial within this time frame. Let's now review the snapshot of the full year P&L on Slide 18. We preannounced preliminary unaudited revenue from global sales of IMCIVREE in January, reporting that net revenue from global sales of IMCIVREE came in at $41.8 million in Q4 and $130.1 million for the full year 2024, as compared to $24.2 million and $77.4 million for the fourth quarter and full year 2023. Gross to net in the U.S. remained consistent at about 85% for both the third and fourth quarters of 2024. Cost of sales during the fourth quarter was $3.8 million or approximately 9% of net product revenue versus 11.5% of net…

Thanks, Hunter. So hopefully, what you've heard is Rhythm is in a really good place. We're established commercially, and we're growing. We've got exciting developmental programs, which all potentially open up significant opportunities for us. And -- we've significantly strengthened our balance sheet, putting us in a really strong position to execute on what's in front of us. So we feel good about where we are. With that, we'll open it up to Q&A.

[Operator Instructions] Our first question comes from Derek Archila with Wells Fargo.

Congrats on the progress. Just 2 questions from us. Just first, could you comment on whether you're going to share the SAD MAD portion of the RM-718 study separately? Or will that kind of be wrapped into the second half '25 update with Part C? And then just on IMCIVREE Phase III trial in HO, I was wondering if you could just remind us the mix of adult and pediatric patients you expect and ultimately, will the split be the same in the Japanese cohort?

Yes. So for the SAD MAD piece of it, I think it is likely we don't have specific plans to present that as an independent breakout. So you're right, we'll probably do that in concert with Part C of that trial. But what I will say about that is it's a little bit of no news, for SAD MAD opportunities, as long as you're progressing, you can assume that things are going well there. So we're -- we feel good about where we are with the data that's coming out so far on 718. For Phase III, the HO adult ped split, we did not -- the regulators wanted more adults in the trial. So we are very focused on that, and got multiple additional adult centers to participate. We're about 50-50. But like I said, we did not cap the number of peds or adults to lock the number to have it be exactly the same. The split is going to be roughly even 50-50.

Our next question comes from Seamus Fernandez with Guggenheim Securities.

So David, you're emphasizing a lot the market opportunity in HO, being quite firm at the sort of 5,000 to 10,000 patient range. Interested to get a sense of with success, how you would see uptake in that population, just more identifiable than the BBS patient population or perhaps even the genetic population. So interested to just get a better understanding there. And then as we've spoken with some thought leaders in the space, there is a little bit of a discussion around sort of the pre-existing obesity set point as a potential contributor because of the hormone replacement dynamics of treatment with setmelanotide. Just interested to know if you feel like that could have an impact on the Phase III HO trial results in any direction given the mix of patients that you just talked about in the Phase III study?

Sorry, Seamus. I didn't quite understand the second question there. So you're saying that the variations in endocrine replacement impact their outcomes?

More that there was a preexisting set point prior to the injury, and that it could sort of limit the magnitude of benefit depending on the timing of that injury.

Yes, let me take that question first. I mean that's a really interesting question. I think the way -- again, we're learning, right? When we entered into HO, nothing really worked, nobody really understood what the underlying biology was. And then we have this result where essentially, every patient who took the drug, small number of patients, took an MC4 agonist, had a response, which suggests that the problem in HO is, in fact, signaling through this melanocortin-4 pathway. And what I highlighted in my prepared remarks was one major difference between the GLP-1s and ourselves is we're replacing a deficit. So in a sense, in theory, restoring normal physiology. And we have examples of that, which is our lean mass, particularly in teenage boys, where you'd expect them to be gaining muscle mass, they did. They gained well. And so I think there's some support for the idea that we're going to restore your normal physiology and then you are who you are. So back to your question of if you were obese prior to getting your tumor, and developing your insult. In theory, we could get you back to where you were before, but our drug is not a drug for general obesity. So that underlying deficit or your underlying normal physiology aren't likely to be impacted, so I think that is true. And I think what we've talked about internally and with experts and the like is our hope and we have some anecdotal evidence of this is we'd like to get you back to where you were before your injury. I think that's a very reasonable expectation, and that would be a huge restoration of health. So hopefully, that answered the question. Okay. And then on the uptake side of this. Yes, we're not guiding --…

Our next question comes from Philip Nadeau with TD Cowen.

Two from us as well. Diving into the HO pivotal data a bit more deeply. In your prepared remarks, you said you expect melanotide to do well on the primary endpoint. I'm sure the question we're going to get from investors is what does management think well is, I guess, in the spectrum of 5% weight loss, which is the regulatory hurdle to 25% BMI reduction, which is what you saw in the the long-term extension kind of where in that spectrum is well. That's the first question. And then second one for Hunter. In terms of Q1 trends, just trying to assemble the data points you gave because it sounds like there was $4 million of inventory build in Q4. Is that likely to be destocked in Q1 and therefore, is a modestly down quarter-over-quarter possible? Or is that going to be absorbed in the channel and put out more slowly?

So I'll take the second question first. And I would say, yes, we absolutely anticipate the destocking to occur in this quarter. So you know how it is, Phil. I mean, Q1 for all companies like us, especially when you have a single specialty pharmacy can always be a little lunky.

Yes, Phil, so the question of what does management think our percent change. The reason, and as I highlighted, we've had this question in a sense endlessly and it's understandable, and I tried to highlight that I think it's coming to a large extent out of how we've all been conditioned by the GLP-1 world and this world is fundamentally different and try to give you some examples as to why those comparisons are challenging. So that said, what do we know? We know that in a small number of patients in Phase II and then the -- this early experience in France -- in France. Essentially, everybody who's taken the drug has responded well. And we know that the average numbers are 20% plus at 1 year and for both of those groups. We also know that we have patients who I gave you the example of the 24-year-old at 16 weeks, right? He lost more subsequently, but at 16 weeks, had lost less on a percent basis and a very light -- a much lighter individual who launch a larger percent of his BMI but a smaller overall absolute amount. So those are just variables that are really hard to predict. We have a larger number of adults in this trial. Now I have no fear. And the adults have looked like they respond well. I think that was an incredibly powerful part coming out of HO. So this long answer to your question is, I mean what we've said is 5% is the regulatory hurdle. We'd be incredibly disappointed for less than 10%. I feel incredibly good about -- I know this drug works. I have the ability to project what percent change we're likely to see becomes much more difficult beyond that.

Our next question comes from Whitney Ijem with Canaccord Genuity.

I just wanted to follow up on Seamus' question around prevalence in HO. And I guess some of the commentary earlier on the call, just around the prevalence numbers that have been quoted, I think, largely being based on craniopharyngioma data. So is there any work that -- I mean I know there's work. So can you speak to any of the work ongoing in terms of the prevalence that might come from other etiologies, including the congenital form?

Yes. So -- it's a work in progress. You're hearing increased confidence around those numbers that we put out because this work is supporting the fact that we're at least that good, we believe. Early things, which we kind of highlight, I will say that -- or aspects of that initial modeling, we're looking at. We entered with the assumption that craniopharyngioma was going to be the majority of cases. That's not necessarily true. There's clearly many more tumors which are contributing significantly to this population. And so that's coming out of some of this early claims work, which we'll see where that takes the ultimate numbers. The other thing was we did our initial calculation with taking a 20-year period post injury. We know these patients live longer. So if you have your tumor at age 15, you're not -- you don't die at 35, you tend to live a much longer life on the patients. So and then seeing that the adults respond well, also, we see that I think there's that part of the model we may have been conservative on. So those are things we'll continue to look at. And we will come out and update these numbers as we get more confidence there. And the last thing I will say, which I again highlighted briefly in the prepared remarks was we're measuring what we can see what the system can see. There's clearly an undiagnosed pool here and we talked about injury and it's still a -- I mean that's a case report world today, and it's way too early to say maybe it's nothing more than a case report. But I am quite confident that if you have a head injury and you suddenly start gaining weight, nobody's thinking you have acquired hypothalamic obesity, so that's a population that is likely to undiagnosed today.

Our next question comes from Tazeen Ahmad with Bank of America.

David, I wanted to ask a little bit more detail about -- I know what you said about your thoughts about not really being able to project what results you'll get other than knowing that this is an active drug and that it works over time. But what have doctors told you about what they'd like to see in terms of percent weight loss in order for them to want to be using it right away in HO patients? And then my second is more of a financial one. You completed your ATM, but you do have this HO dataset readout coming up very soon. Would you rule out doing a cash raise after that data set reads out, assuming that it's positive?

Yes. Thanks, Tazeen. I'll let Hunter answer that question, of course. But to be honest, we're not asking the doctors that very direct question, would you use it if we had a 12% or not use it if it was 12% and you would use it if it was 15% or 18%. What the doctors are telling us is nothing in general, works in this. Now we all know there's case reports out there and small series with GLP-1s and we quoted I've quoted what some of the doctors have said that about 20% of the HO patients will have some response to a GLP-1, and that response tends to be less than 10%. So I think where the doctors are certainly the doctors who are knowledgeable and actively understand this problem and following them is, if this is approved, labeled and indicated for this indication, and is anything like our experience to date, it will be an amazing difference for these patients today in terms of what they're experiencing with experiencing. So I just can't give -- I have no idea when projecting a percent outcome in a clinical trial, of course, incredibly difficult. But I really think it's the wrong question. And I think it's not what the majority of doctors who are treating these patients are focused on. They want to know does it work consistently and does it work better than what they've had in the past.

And Tazeen, to your second question, and thank you very much for the question. First of all, I'm sure you're hearing, and I want to reiterate that we have very, very high confidence in this data readout that's coming up. And we're, at the same time, given the uncertainty of the broader market conditions as well as the vagaries of market reactions to data, we thought it prudent to take -- to extend the runway to a period where we didn't absolutely have to do a raise following the data. And we're now in that position. We're very happy to be here, and we think it benefits our overall operational flexibility. Our investment program for the coming years is generally associated with bivamelagon and RM-718, an indication expansion. So the need to invest more and the need to raise more will be driven largely by success in those programs, which is exciting. And so we're not in a position today where we would say, no, we're done raising money or anything like that. Having said that, we want to be in a position which we are in, where we don't have to do a raise following the readout.

Our next question comes from Joseph Stringer with Needham & Company.

Just on the Phase III HO trial, the inclusion criteria has slightly different age groups compared to the open label Phase II where Phase III, it's including 4 to 6 year olds and then also patients older than 40. So can you describe what impact the inclusion of each of these groups patients could have on the Phase III BMI primary endpoint, both in terms of magnitude of effect in overall data variability?

Yes. No, thanks, Joey. None, again, and I say that cautiously, meaning that we had patients down to 6. I think the difference between 4 and 6 is negligible. I think the 4-year-old we'll do as well as the 6-year-old. The French data was incredibly helpful. And these were the 8 adult patients we reported out at TOS. They had -- if you remember, they had a mean age of 30, so some were significantly older than 30. And on average, they were 11 years out from their insult. So that provided strong support for this concept that this isn't a problem that only works if you can get it in, in the first 1 to 2 years post injury. It really looks like it doesn't matter how far out you are. And once you've injured your hypothalamic you're living with impaired signaling to the MC4R you're living with it. And if we can intervene with an MC4R agonist and we've got a good chance of helping those people. So I don't think either end of the spectrum is going to have any impact on how we're going to do. And one other thing I'm just going to offer up because I know, again, the people are appropriately focused on sort of what could the percent change be? And another thing to remember is in that Phase II trial, the patient who did least well at 16 weeks, meaning they had about a 4% decrease in their BMI. That was the only patient who took the drug who did not lose 10% or more was on track to lose 10% or more by 16 weeks. That patient, when you -- it looked like they were the least good responder. When you looked at the DEXA scan, they had like a 20-plus percent increase in their lean body mass and a 15% decrease in their fat mass. So from a health response standpoint, arguably, that was one of our best responders. So again, back to this idea that we're replacing a deficit, restoring more normal physiology and allowing you to do what you should do. So teenage boys should put on lean muscle mass. Other groups will behave differently.

Our next question comes from Leland Gershell with Oppenheimer.

We have 2 questions. First, Dave, I just wanted to ask, it's early days, but since the label expansion to just want to see to what extent extension of things in the younger ages is becoming a component of commercial uptake. And then also I want to ask, as you look to enroll patients with congenital HO, you could just review the maybe similar to the fecal those patients are identified versus your other historical general -- genetic therapies.

Yes. Let me take the second first and then Jennifer can comment on the 2- to 6-year-old opportunity. So we're learning about the congenital HO opportunity. And again, this was brought to us by doctors who are following like populations here. And what they observed is patients with this area of the brain, not developing appropriately, and there's a variety of different syndromes "depending on how they present". But it's clear that there is some percentage of these patients who have obesity, and the very early data in France suggests that some of those patients respond to an MC4R agonist. So our challenge and the literature just is not very helpful here yet, understanding the percent of patients with one of these congenital syndromes who have obesity and then 1 step further, which is that, that obesity is related to hypothalamic impairment. And I think the challenge here is unlike an injury setting where you have it before and after, these, of course, are congenital,they start at birth and they emerge over time. Their pituitary insufficiencies emerge over time. It's not like they're born with a full-blown picture. So as obesity might emerge, you can imagine that a doctor looking at that patient wouldn't necessarily connect with you have this congenital syndrome and our obesity is related in today's world, it's equally likely they just think you have obesity on top. So that's our challenge. I think we're going to learn a lot over the next year. Like I said, there's a lot of enthusiasm around this. As we talk to physicians, again, it's a little bit like HO. Yes, I have these patients. And yes, I would love to have something to do for them. So very early, as you said.

Another point about the the potential opportunity for the pediatric expansion. One, I would say that in Q4, really an indication came quite late in the year. So it didn't have an impact in terms of the outline of the revenue that we released. Moving forward, we are very happy to have this as an option for patients to our 2-plus years of age. And as I outlined during my story around Ben's background, the impact can be significant for these patients. However, we don't feel like it's going to be a significant market opportunity just in terms of significant increase or impact on revenue. We are more happy to have this as an additional piece of information that really further differentiates our patient population in terms of the need to be able -- which is shown by the ability to actually get approval for a 2-year old plus. So that consistency and differentiation of our patient population in IMCIVREE is what we're really focused on moving forward.

Our next question comes from Dennis Ding with Jefferies.

This is Anthea on for Dennis. Two from us. On the upcoming Phase III Ho trial, could you talk a little bit about GLP-1 use at baseline? And if drop-ins are allowed throughout the trial and how you anticipate that to impact efficacy? And then on the pivotal Phase II, do you see any read-through from this melanotide trial in terms of efficacy as well as enrollment and the adult pediatric mix?

Sorry, which Phase II trial? For biva. Read through in term -- say it again, what's the question about the biva trial? .

Yes, do you see any read through from the setmelanotide trial in terms of efficacy and then also in terms of enrollment and the adult pediatric mix?

Yes. So that's a 28-patient 4 arm, so 7 patients for our blinded trial. So we have obviously no insight into the efficacy at this point. We didn't restrict it. It's 12 and older. So it's a slightly older population. We need -- we're still developing the pediatric formulation for biva, which we're making great progress on, and we'll that will be part of our next trial, but we don't have that part of the population. So that's all I can say now about the mix of patients work at the [indiscernible] with regard to GLPs in the Phase III trial, so about 25% of the patients had previously been on a GLP and/or were continuing a GLP. If they continue to clip, they could not have had weight loss of 2% or greater in the prior 3 months. And so you had to be stable on it. And you cannot add a new weight loss medication during the trial, and that didn't happen, but that was excluded by protocol.

Our next question comes from Ram Selvaraju with H.C. Wainwright & Comany.

And congrats on all the progress recently. I just wanted to ask if you could comment a little bit more on the recent impact of the label expansion for IMCIVREE and what specific dynamics you're seeing in the U.S. market regarding patient acquisition, patient adherence and how that compares to the ex U.S. experience that you've had since that label has been in place for longer outside of the U.S.? And the second question is, if we think about the Trispera relationship that you have announced, to what extent is this likely to be a template or a model for future relationships in ex U.S. territories? Is this likely to inform to a significant extent your future ex-U.S. BD activities? Or is it very much kind of individualized to the Turkish context?

Yes. So Yann, can you comment on the -- your experience -- international experience here with 2 to 6. Jennifer just commented on the U.S. and how you see that impacting the overall opportunity. and then, of course, how we think about distributorships and partnerships.

So yes, thank you. So pediatric in Europe. So we have now treated patients younger than 6 in a few countries, in France, in Germany, in the U.K. and Spain, and we'll continue to see more of that. As Jennifer said previously, the impact on revenues will not be significant, but the impact for the patients and for the caregivers, and also for the clinicians is a significant one. So in a nutshell, that's what I can say about the pediatric indication in Europe.

And then maybe you can build on this. And so the way we think about distributorship, it is country by country. I mean our general approach is to go direct where we can and then be practical and smart about where we need to leverage additional help. So maybe just a little bit of thinking behind the decision to use that distributor in Turkey and how that might represent or be an indicative of our thinking going forward.

Yes, exactly, as you said, David. So I think we choose country -- our approach country by country. Of course, in the main European countries, we are direct for some specific territories where we believe that the expertise in the ground is better with partners than what we do. And we have done such with medicine in Israel with Genpharm in the Middle East and now with Trispera in Turkey, and we have to say that we have been very happy with these 3 partnerships. .

Our next question comes from Jon Wolleben with Citizens JMP.

Just wondering in the Phase II, we did see some patients who dose reduced due to AEs, so a regain of BMI, which gives us confidence in the drug effect. But wondering the Phase III protocol, if you're allowing dose reductions for AEs during the 52-week period or if everyone's set after the dose titration period?

Yes. No, good question. So the protocol is set to everybody dose escalates to 3 as tolerated. If you can't tolerate it, then you stay a little longer at that dose to hopefully acclimate most patients do and then dose escalate again and/or if you truly are having trouble, you can dose decrease. So it's a dosing paradigm that does allow titration to tolerance. Now the vast majority of patients get to the desired dose at 3. Not everybody's needed to go to 3, and I know this has been a question out there. I do think the HO world is going to end up somewhere between 2 and 3, BBS weighs a little heavier to the 3. I think HO will be more firmly in the 2 to 3 range. But individual patients, and we had one in the trial who just couldn't tolerate it and ended up stopping the drug, yes, we may lose something like that, but that's quite uncommon. And again, I'll remind you, we've only had -- we've had fewer than 10% dropouts in the trial so far. So that doesn't seem to be an issue in the Phase III.

Okay. And one more, if I may. You talked a little bit about the bivamelagon and 718 being having less activity at MC1. Wondering -- can you talk about the relative activity at MC4 between the next gens and setmelanotide, you say efficacy is kind of TBD, if there's going to be a difference there. But can you talk about the specificate the MC4 receptor between those 3 candidates.

Yes. So we -- the 718 and setmelanotide in in vitro assays functional looking at potency are highly similar. We are -- the potency as it was assessed for bivamelagon was done in a different assay. It wasn't done head-to-head. We were actually running that now. I don't have those full results now. But -- so I can't comment on that within the same assay comparison. What I can say is the preclinical data -- and again, it's on a milligram per milligram base, obviously, an oral drug, you've got absorption and availability and the like. So a lot of factors, so your dosing is much higher on a milligram basis obviously. But we can get -- or they got in an extensive set of models, similar results using the dose of bivamelagon, as we saw with setmelanotide and with 718. And the doses that are being used in the trial were built off of that understanding. So I think we are likely to be in a therapeutic range, and I'm expecting that we're going to get adequate MC for agonism across each one of these.

I'm showing no further questions at this time. I'd like to turn the call back over to David Meeker for any closing remarks.

Okay. Well, great. Thanks, all again for tuning in this morning. As you heard, we're excited about where we are, and we look forward to our next call, which we'll be updating you on some exciting information. Thanks, all.

Thank you for your participation. You may now disconnect. Everyone, have a great day.