Good morning, ladies and gentlemen. Thank you for standing by. And welcome to the UroGen Pharma’s Fourth Quarter and Full Year 2020 Financial Results and Business Update Conference Call. It is now my pleasure to turn the call over to Sara Sherman, Head of Investor Relations at UroGen Pharma. Please go ahead.

Thank you, Jonathan. Good morning, everyone. And welcome to UroGen Pharma’s fourth quarter and full year 2020 financial results and business update conference call. Earlier this morning, we issued a press release providing an overview of our recent corporate highlights and financial results for the quarter and year ended December 31, 2020. The press release can be accessed on the Investors portion of our website at investors.urogen.com. Joining me on the call today are Liz Barrett, President and Chief Executive Officer; Dr. Mark Schoenberg, Chief Medical Officer; Jeff Bova, Chief Commercial Officer; and Molly Henderson, Chief Financial Officer. Please note that we continue to conducting our calls from different locations, so we appreciate your patience and understanding should we have any technical difficulties. Liz will provide a summary of our recent corporate developments, Mark will share clinical development updates, and Jeff will provide a commercial updates. Molly will then provide an overview of our financial highlights for the fourth quarter and full year before we open the call for questions. During today’s call, we will be making certain forward-looking statements. This may include statements regarding the timing of our ongoing and planned clinical trials, Jelmyto commercialization, data presentation, potential regulatory filings, future research and clinical development efforts, our ability to change treatment paradigm, manufacturing capabilities, future expectations, plans and prospects and 2021 financial guidance among other things. Actual results may differ materially from those indicated by these forward-looking statements as a result of various important factors, including those discussed in the Risk Factors section of UroGen Pharma’s annual report on Form 10-K filed with the SEC this morning, and other filings that UroGen Pharma makes with the SEC from time-to-time, as well as any negative effects on UroGen’s business, as well as commercialization and product development plans caused by or associated with the COVID-19 pandemic to the extent not disclosed previously. We encourage all investors to read the company’s annual report on Form 10-K and the company’s other SEC filings. These documents are available under the SEC Filings section of the Investors page of UroGen’s website at investors.urogen.com. In addition, all information we provide on this conference call represents our views only as of today and should not be relied upon as representing our views as of any subsequent date. While we may elect to update these forward-looking statements at some point in the future, we undertake no obligation to update any forward-looking statements we may make on this call on account of new information, future events or otherwise. I will now turn the call over to Liz.

Thank you, Sara, and thank you to everyone joining us today. It’s not an understatement to say that 2020 was memorable for everyone. Despite the challenges we face collectively, it’s been inspiring to see how innovation in the pharma and biotech industries have persevered to the benefit of society. Although, this is what our industry does day in and day out, I am grateful to see that heroic efforts being universally applauded. While that work has rightfully been on the forefront, many diseases don’t become front page news, but they do take center stage for the individuals who have been diagnosed. UroGen is focused on developing treatments, focused on urologic and specialty cancers. Last year, our first approved therapy Jelmyto became the first and only FDA approved non-surgical treatment option for adult patients with a low-grade upper tract urothelial cancer. Although, launching Jelmyto in the midst of the COVID-19 pandemic certainly presented challenges. We are incredibly pleased with the way our team has responded to those challenges in the first two full quarters of launch. We recorded $8 million in net product sales for the fourth quarter of 2020 and $11.8 million since June 1, 2020 launch. We continue to be mindful of the environment we’re operating in, including the vaccine rollout and its impact on the healthcare system and the patient populations we serve. We have seen these trends have an impact on patient procedures, including Jelmyto uptake in the first two months of 2021. We continue to closely monitor, and Jeff and Molly will provide more details on our progress shortly. But we remain confident in the outlook for continued and accelerated adoption as the year progresses. And the demonstration of what’s possible makes us even more enthusiastic for what’s to come. We’ve made important progress in advancing…

Thank you, Liz. It’s exciting to see the impact Jelmyto is having on real world practice and an exciting time for patients, as we continue to expand our pipeline in important areas of uro-oncology. During the fourth quarter of 2020, Dr. Surena Matin from MD Anderson presented the final durability data from our Phase 3 OLYMPUS pivotal trial evaluating Jelmyto in low-grade upper tract urothelial cancer in a virtual podium presentation at the 21st Annual Meeting of the Society of Urologic Oncology. We were pleased to see that in both the OLYMPUS intent to treat population and in the sub-population of patients who were deemed to have unresectable disease. At study entry 58% of patients achieved a complete response with durability of response at 12 months estimated to be 81.8% by Kaplan-Meier analysis. Median time to recurrence was not reached. The safety profile in the OLYMPUS data was consistent with previously reported results. This was previously a disease where options for patients included multiple endoscopic procedures or the removal of the kidney and ureter, both of which have consequences impacting patient health and quality of life. These final durability data from OLYMPUS were in line with our expectations and support the use of Jelmyto as a less invasive kidney preserving durable treatment for a low-grade upper tract urothelial carcinoma, which may reduce the need for multiple endoscopy procedures or loss of a kidney. We also have several updates to provide for our UGN-102 program since our last quarterly call. The first of which is the final topline data from the OPTIMA II Phase 2b trial evaluating UGN-102 as primary therapy in patients with low-grade intermediate risk non-muscle invasive bladder cancer that we announced in November. This study shows that 65% of patients 41 and 63, received the UGN-102 achieve the…

Thank you, Mark. I’m pleased to provide you with an update on our commercial launch of Jelmyto. As Liz mentioned, we achieved $8 million in net product sales in the fourth quarter of 2020 and $11.8 million from the start of Jelmyto launch on June 1st through the end of 2020. This represents a great early start to the launch and is a testament to the important work the team is doing and the value that Jelmyto can bring to adult patients with low-grade UTUC. The feedback that our team continues to receive from physicians treating their patients with Jelmyto remains extremely positive and we are seeing firsthand the tremendous impact that Jelmyto is making in the lives of patients. The most consistent and recurring themes we hear include patients avoiding surgery and achieving a complete response post-treatment, consistent with what we’ve observed in our clinical trial. We’ve heard from a number of physicians who have treated their first patient with Jelmyto received a promising response and are now working on identifying additional patients. In November of 2020, we announced that CMS established a permanent and product specific J-Code for Jelmyto, which took effect on January 1st of this year. The J-Code replaces the previously issued and temporary C-Code, and standardizes and facilitates reimbursement in the hospital outpatient, ambulatory surgery center and physician office settings of care. This J-Code is helpful in simplifying and streamlining reimbursement for physicians and we believe it will translate into improved access to Jelmyto throughout 2021. There are a couple data points I’ve been sharing on our calls to help illustrate the success of the launch to-date and the growth that we’ve seen early on. The first is activated site. As of March 1st, we have increased our activated sites over 250 sites up from…

Thank you, Jeff, and thank you to everyone who joined today’s call. Before I discuss our fourth quarter and year end 2020 financials, I’d like to touch upon the strategic transaction announced this morning with RTW and provide some details. We are pleased to partner with RTW and an influential healthcare investor whose mission is to invest in innovative companies looking to bring important new products to patients. RTW is research driven and we believe this investment reflects their confidence in the UroGen team and the important impact that Jelmyto has on patients, as well as the excitement surrounding the potential opportunity for UGN-102 and non-muscle invasive bladder cancer. The $75 million in funding from RTW puts us in a solid financial position to support the continued launch of Jelmyto and the development of UGN-102, in return RTW will receive tiered future cash payments based upon global annual net sales of Jelmyto equal to 9.5% of annual net sales up to $200 million, 3% of annual net sales between $200 million and $300 million and 1% of annual net sales above $300 million. If certain annual revenue thresholds for Jelmyto aggregate worldwide net sales are not met, the future payments with respect to the first year of net sales will increase by 3.5% and that’s subsequently decreased depending on meeting certain annual net sales thresholds. In addition, RTW will receive tiered future payments based on global annual net sales of UGN-102 subject to FDA approval, equal to 2.5% of annual net sales up to $200 million, 1% of annual net sales between $200 million and $300 million and 0.5% of annual net sales above $300 million. Payments based on net sales of both Jelmyto and UGN-102 will terminate upon the date that RTW has received an aggregate amount equal to…

Certainly. [Operator Instructions] Our first question comes from the line of Chris Howerton from Jefferies. Your question, please.

Excellent. Good morning and thanks for taking the questions and really appreciate all the progress through a pretty difficult year last year. Great, so I guess maybe is to start things off, in terms of, Jeff, for the repeat customers that you saw in terms of the accounts. I guess I’m just wondering if there’s any trends that you see there, categorically is that more tend to be academic centers, community centers is -- what’s your expectations there or kind of what you’re seeing, first of all? And then secondly, with respect to the first quarter revenue numbers, I guess, I just want to fully understand the expected dynamics to the net revenues. I think, Molly, you said that there were some weather related shipment delays and then there was also, perhaps, some larger orders in the fourth quarter. And then, perhaps there’s also something to be understood with respect to the payer environment, payment plan resets or anything like that? I guess, just maybe help us better understand the expected dynamics for the first quarter revenue numbers? And I think maybe that’s it for now and I might have a follow-up.

Hey. Chris, thanks. It’s Liz. How are you? I’ll turn it over to Jeff to answer your first question and then, Molly, you can talk a little bit more about Q4 and Q1. So Jeff?

Thanks, Liz. Hi, Chris. And to address your first question that, the multiple or the patients or the physicians that have multiple patients, it’s primarily probably 60% to 70% are those in the hospital. But we do have community accounts that have multiple physicians writing Jelmyto for their patients or single physicians that have identified more than one patient as well. So my expectations I can -- I -- as I said in the past, I continue to expect this will translate more into the community, some more community practices will begin to adopt and treat multiple patients. But for the time being, the predominant number of multiple patients are coming out of the hospital setting.

Great. Okay.

Hi, Chris. To answer your question on the Q1 revenues, so as Jeff and I both alluded to, we started to see some softness as we went into January and February this year. A lot of the reasons we discussed in our narrative around the vaccine rollout and some other impacts as it relates to weather. To that effect, we’re starting to see the rebound of that. And I think when we look at the patient population that we serve, it was the same patient population that was getting the vaccination or in the queue to get vaccinated. And so that really trends in line with kind of the rebound we’re seeing in March. We’re still in the first quarter. So we’re not going to provide any more…

Right.

… clarity as far as where we expect, because we still have a few more -- a couple more weeks to go. But we certainly wanted to flag that the market, because those are some of the dynamics that we’re watching.

Okay.

And then, maybe, lastly, as it relates to some of the stocking charges we saw last year, I referenced about a $500,000 to $800,000 estimate based upon some indication we got from certain practices that they were looking to stock and/or get ahead of any shipment concerns. Remember, last year’s holiday season, there was a lot of delays in shipments. So we saw some of that in advance buying last year and we’re not going to see a similar pattern. So one of the queues and market into some of that dynamic as well.

Okay. Great. And maybe just as one clarifying question with respect to that, in terms of the shipment delays in the first quarter, did that impact any kind of treatment schedule or any effect in terms of the payment -- patients or just maybe like initiation of treatment, just a clarification there? And then another question for, Mark, would be what do you expect the impact could be of in-home installation and is that primarily in the context of the COVID environment may be very impactful and not so much outside of that or maybe just how you’re seeing that, would be helpful to understand? Thanks.

Jeff, do you want to take the impact to patient treatment?

Sure. So it did impact. We had a few that needed to be rescheduled. Fortunately, the OLYMPUS trial was designed that though it’s once weekly and not everyone was got a dose every seven days. So they were able to miss a day or two in the OLYMPUS trial, therefore physicians held comfortable, and obviously, given the weather that we had, shipments were delayed by a day or two, they just simply reschedule those patients.

Got it.

Yeah, Chris…

Mark? Yeah.

Yeah. Chris, thanks for the question about home installation. I think this is an example of something that was really fostered in the company, which has been, I think, accelerated by COVID, which is thinking innovatively and out of the box. The concept of home care for patients with recurrent disease is really a very innovative one. But it’s possible with this therapy. And so we want to explore that because we think it represents a very positive step in the right direction for this population. And obviously, we have to do the study in order to examine whether it makes sense, but it is a really interesting and I think an innovative way of thinking about the next iteration of treating patients. And COVID, I think, has made us think about this in accelerated fashion. So I think it has had a little bit to do with COVID. But I also think it’s completely consistent with our larger corporate goals, as you heard, Liz, articulated many times.

Yeah. Okay. All right. Well, great. Thanks so much for all the answers and again appreciate all the progress.

Thanks, Chris.

Thank you. Our next question comes from the line of Derek Archila from Stifel. Your question, please.

Hey. Good morning, everyone, and congrats on the news and the updates here. So just two questions from us. I think the first one is for, Jeff. I just wanted to get an understanding is how you think the sales ramp and the trajectory for Jelmyto may be impacted with the J-Code now that you have it, maybe you can kind of talk to some of the things that have happened or some of the trends thus far in the first quarter? And then maybe the second for Liz and Molly, now with the RTW investment, I guess, do you think this is enough run way to get yourself to profitability, I just kind of curious how you’re thinking about that? Thanks.

Sure. Good morning, Derek.

Yeah. Jeff, you can answer.

Yeah.

Right.

So with regards to the J-Code, I -- what we’ve seen particularly in the community, the community, whether it’s warranted or not, tends to be a little bit -- have a little bit more anxiety in around miscellaneous code and so they liked having the J-Code the product specific code. They’re being trained with the CMS. CMS has give them guidance on how to build correctly for the drugs. So it certainly is helped with regards to uptake in the community roles as I expected to continue as well having a permanent J-Coe.

Molly, do you want to give your perspective on the financing and then I’ll chime in as well.

Sure. Hi, Derek. Yeah. So we’re excited to announce that financing this morning. We haven’t provided any specific guidance on when we anticipate to breakeven, but it’s safe to say this additional funding gets us into 2023 and certainly allows us ability to continue the launch efforts that we have on Jelmyto and the ATLAS trial relating to UGN-102.

Yeah. I think, Derek, the other -- only other comment I’ll make is, we’ve had a lot of questions and comments from investors and around needing to raise money, obviously, and people wondering where we’re going to go back out to the market and this is non diluted financing. And so we just, I think, this hopefully answers that question. And we don’t have a need to go out to the market right now, and I think, it depends we’re well funded to do the things that we need to do right now. I think there’s always the question of business development, right? It’s something we get, we find something, we’re excited about, we’re constantly looking for new opportunities. But so if we find something we’re excited about that might change things. But at this point in time, I think, as you I’m sure can tell, we’re funded where we need to be and don’t expect to be doing any diluted financing anytime soon. So thanks for the question.

Yeah. Thanks. Congrats again.

Yeah. Thank you, Derek.

Thank you. Our next question comes from the line of Eric Joseph from J.P. Morgan. Your question please.

Good morning. This is Hannah on for Eric. Thanks for taking the question. Just a few from us. So now that you’re further into the launch, are you able to speak a little to the frequency of maintenance therapy use in the commercial setting? You mentioned earlier that a number of patients have seen a complete response, but have you been able to determine what proportion of patients are achieving a CR and how that was compared to the OLYMPUS trial? And then I have a follow-up after that.

Yeah. Jeff, why don’t you take those?

Yeah. As I have said, it’s consistent with what we saw on OLYMPUS -- the OLYMPUS trial. We -- whereas the physician if they choose to tell us how the patient is doing that’s information that we have. We haven’t really, maintenance has been something that is in the -- it’s at physician discussion. I will say this, we have more patients, more physicians considering maintenance and putting patients on maintenance, but that the bulk of, the majority of the patients are getting the treatment, the six doses with no maintenance.

Yeah. The only comment about CR, what we are seeing is, Jeff comment, that’s anecdotal, right? We don’t capture real world, we’re not capturing real world CR. But from what anecdotally, I would say, at least as good or better and we have -- we’re -- it’s well tolerated and we do capture, obviously, MEA’s [ph] that have to come in to the company and so we feel really good about not only the efficacy but the safety as well. So you said you had a follow up question, Hannah?

Yes. You had mentioned a little while ago interest in pursuing a retreatment trial, just wondering if that was still of interest and if there’s any particular timelines where we might see that come to fruition?

Yeah. We’re definitely interested in that and we will start that study as soon as it’s feasible. The reason I say that is because patients have to recur, right? So they have to do well on the treatment and then have a recurrence. So we would not see the start that study, obviously, patients are just starting on the treatment in the last six months. So we wouldn’t expect to start that site till the end of this year, really into probably 2022. Having said that, just we do know that there were patients that were in the study that have gotten retreated, it is in our label today, but we would like to generate additional data on retreatment. It’s not stopping physicians from retreating patients. As I said, it’s part of our label. But we would like to capture data. But that’s -- it will be quite a few months before we’ll actually be able to even start that study.

Okay. Great. Very helpful. Thanks for taking the question.

All right. Thank you.

Thank you. Our next question comes from the line of Matt Kaplan from Ladenburg Thalmann. Your question, please.

Hi. Good morning and let me add my congratulations to the progress. Just wanted to dig in a little bit to kind of the dynamics of patients receiving treatment that you’re seeing, I guess, given the pandemic and patients not seeing the doctors as you and diagnoses going down. Are you seeing some sort of a backlog of patients, given this backdrop and do you think these patients have been did by practices and are just awaiting therapy that you’ll start to see them roll in to receiving the treatment sometime this year?

Yeah. Hi, Matt. It’s Liz. Thanks for the question. I am going to ask Jeff to comment. But before, he does, I think, we would speculate, right, that even in the beginning of our launch, there were some patients that had not come in as you saw COVID cases go down somewhat we did and Jeff did nice work on understanding the dynamics of COVID versus our patients. And you can clearly see that when diagnosis of COVID went down, patients went up. So we do think that even in the first six months of the launch, were likely patients that had been kind of waiting. And so, I think, that dynamic exists. It’s hard to quantify. But Jeff, we’d love for you to share with Matt, your perspective.

Sure. Thanks, Matt. And I guess to easily answer the question, it depends on the where in the country you are, how bad the cases have been, when did they put into place that they put in a delay in elective procedures. I will say majority that had put in electric procedures are on hold. I have now open elective procedures up. And to your point, Matt, they do begin then to prioritize these patients. And so as we see -- as we’ve seen with COVID going down, cases going down, we’ve seen an increase in patient enrollments.

Okay. That’s helpful. And you mentioned in your prepared remarks that you have now, I guess, over 250 sites activated. Can you give us a sense in terms of the number of those sites that have treated a patient so far?

Liz…

Yeah.

…we haven’t provided, yeah, those…

No.

…exactly.

Exactly.

Yeah. Okay. And then, I guess, maybe a question for Mark on the ATLAS study. Can you give us a sense in terms of, just remind us of the kind of the endpoint and the powering of that study for the low-grade intermediate risk non-muscle invasive bladder cancer?

Sure. Thanks, Matt. I’m sure as you probably remember in our discussions, the primary endpoint is recurrence free or disease free survival. And it’s an event driven trial. So the objective here is to look for curb separation between the group receiving primary UGN-102 versus those who are treated primarily with surgery. There are planned interim analyses that are event driven. So we can’t tell you when those will occur. And I think that’s probably about what we’ve shared along with the fact that we know that in the control arm, we expect recurrence rates to be approximately 50% or higher at a year, we’ve been pretty conservative about our design. So I hope that’s helpful in terms of thinking about the trial. But the primary endpoint is recurrence free survival. And Liz may want to comment further on this as well.

No. I think that’s right. I think the powering to your point -- to your question, Matt. As Mark said, we used around a 50%, knowing that, in the literature, anywhere from 50% to 80% of those patients will recur if they only have a TURBT and are -- meet the criteria for intermediate risk, and obviously, we used our own Phase 2 data for the assumptions, but on a conservative side for us as well. So put ourselves in a position where we can be successful from a technical standpoint.

Great. Thanks for that detail and thanks for the questions.

Thanks, Matt.

Thank you. Our next question comes from the line of Paul Choi from Goldman Sachs. Your question, please.

Hi. Good morning, team, and let me add my congratulations on the progress as well. I want to maybe just revisit ATLAS, if we could, and just with regard to your comments with regard to patients being treated at home. I guess my question is twofold here first. Do you see this as potentially for this low-grade intermediate risk population as a potential real world treatment paradigm versus being treated in the clinic or in the hospital? And then secondly, if it would be -- if there is potential for at home treatment model here, how does that potentially affect the economics of UGN-102 or just like a function of the environment we’re in currently?

Yeah. Thanks, Paul. How are you? The -- I think, from our perspective, we want to make things as easy as possible on patients. You start to think about TURBT. I think one of the missed information, misunderstanding is that, people think of TURBT, no big deal. As we share 57% of the patients in our study had three or more TURBT, the patient population we’re talking about. And as they have more and more we know it’s an independent factor of mortality. So, we’re saying how one can we differentiate our therapy from what’s there today, which, frankly, doesn’t work. And we do know that more and more, this is an elderly patient population. So it’s just one additional way. We still think that, frankly, the majority of the patients will go in to the clinic to get treated. But having an opportunity to treat these patients at home, I think will be a benefit to some of those patients who are unwilling or unable to get to the doctor, make it easier on them. I don’t think it will impact the financials at all, because obviously, you would get treated at home. They -- it would be through a home health company. So I guess the difference is for physicians, obviously, they would make more money if the patient comes into the office, but the -- again ability to offer that to patients and have that as an option, we think is important. So the financials for us don’t really change the financials for the office, obviously, would if the patient came into their office, they would see the revenue associated with that.

Okay. Thank you for that concept, Liz. And then maybe as a follow up either for you or for Jeff, just with regard to your comments on the trends you’re seeing so far in the first quarter here. Can you maybe just help us conceptualize in your view is this more specific to this quarter, given the various factors such as COVID that you mentioned here or with regard to historical practice and in this population on the commercial side? Is this more reflective you think of typical seasonality in the Medicare population and doughnut holes and put those kinds of factors? Any clarity on that point would be great?

Yeah. Jeff, you want to comment and maybe I’ll add something after.

Sure. No. That -- we have a very small number patients of Medicare that don’t have supplemental. I don’t think that’s a great impact as much, so as we’ve seen with sort of prioritizing the vaccine, both from a patient standpoint and a hospital or provider standpoint. We -- the good thing is the majority accounts that we’re -- that we had out there are the accounts that we’re pushing off formulary view are now reviewing. Things are starting to get back to normal within the provider. But I -- there’s a very minimal impact with regards to out of pocket, because majority of our patients have supplemental insurance.

Yeah. And just…

Okay.

… comment about the trends. We don’t think that it will continue that way. As a matter of fact, as Molly mentioned, we’ve already seen it start rebounding in March. So, it made sense that these patients and the physicians, one, now that the vaccines available, wait a few weeks, get the vaccine. There’s tons of publications out there and literature out there that says that across the Board, hospitals around the country, institutions around the country are doing that. Not just obviously in this instance, but across the Board. And so we don’t expect to see that trend continue and as Jeff said, we think we’ll be in a good position. So for us, the outlook on the year hasn’t changed at all, right? It’s just more timing thing.

Okay. Thanks for the call, Liz, and congratulations again.

Great. Thank you.

Thank you. [Operator Instructions] Our next question comes from line of Ram Selvaraju from H.C. Wainwright. Your question, please.

Good morning. This is Mark [ph] speaking on behalf of Ram. Thanks for taking our questions. I have a couple of COVID impact questions and then two follow-up. First on the Jelmyto sales effort being conductive in the context of COVID-19, do you anticipate being able to conduct same promotional activities in the coming months that you weren’t able to perform previously? And because the COVID-19 pandemic is progressing [ph] down and then in terms of the ATLAS trial enrollment, you mentioned, you expect to provide enrollment update there, I mean -- but I mean, do you see any logistical challenge in execution of the trial due to COVID-19 and if so, what are they using, how are you mitigating that? Thanks.

Yeah. I’ll comment about the study. I would say, not really, we anticipated that there would likely be delay, so our expectations for enrollment. We’re obviously -- from an amount of enrollment, obviously, it starts slow anyway. We did make sure that we sort of around the world doing the study. There were a couple of countries that, that delay started the study, but then there were other countries that didn’t. And so we’ll continue to work through that. But we felt like we have enough sites and is one of the reasons that we actually increase the number of sites versus our initial expectation, because we wanted to make sure that with COVID, if a country or area shutdown, that we would be able to sort of makeup that enrollment elsewhere. So, and then, Jeff, do you want to comment on promotion?

Sure. So what we’ve seen is an increase in face-to-face interactions. I was fortunate to get out with some accounts last week, a couple weeks ago and the face-to-face is improving. So they’re opening up to face-to-face interactions. And more importantly, they open up to have representatives come in and do presentations over lunch. So a lot of places that have limited lunches or face-to-face interaction are slowly beginning to open those interactions up. Where that’s still limited, we continue. The field does an excellent job of continuing to have virtual reminders, virtual presentations with the physicians, being mindful and respectful of what the office prefers at this time. But I am happy to say that, yes, there’s more face-to-face that are taking place, I can -- I see that continuing as COVID cases go down.

Okay. Excellent. And do you expect the difference between the number of sites activated and the number of sites they have treated more than one patient with Jelmyto to narrow substantially over the course of the next several quarters? And if not, why do you think that, why not?

No. I expect both to grow. I mean, I think, someone asked a question to, the -- we want all of our sites activated, treating more than one patient. I mean, we want to get to the point where physicians are opening it up. We’ve had that too. You have initially you obviously have a champion in the office. But they ask and the goal of the reps -- representatives are to go in and open it up to the other physician. So you have it. So I expect both numbers to continue to grow as we’ve got a large number of accounts that either putting it on formulary, have it on formulary, looking for a patient and then once they experience using Jelmyto with the patient, either finding more patients or certainly that that peer-to-peer influence that I talked about, discussing it with other physicians during their, all of these accounts have tumor boards or medical meetings with their urologist. Making sure that we’re part of that agenda is a key goal for us to get the majority of the urologists within an account considering Jelmyto for their patients.

Okay. Great. And then just the final two housekeeping questions. So, are there any timeframe restrictions on the funding received from RTW investments? So, in other words, does RTW have right to impose additional conditions or require additional consideration of the $300 million amounts not paid back within a specific period of time? And will are these additional commissions if any, so if funding from RTW secured by any of UroGen’s IP tax?

Molly?

Yes. Maybe -- yeah. Sure. To answer that there’s no timeframe commitment in the event that $300 million is achieved over certain period time. So that there’s no -- to answer that question, there’s no time commitment. As far as collateral, certainly, they have a security main interest on the strip of Jelmyto. And then that’s carved out within the IP interest as well, but certainly nothing that we believe would prohibit us to look at ex-U.S. or other BB tech activities in these products.

Perfect. Makes sense. Thanks for taking my questions.

Great. Thank you.

Thank you. This does conclude the question-and-answer session of today’s program. I’d like to hand the program back to Liz Barrett for any further remarks.

Great. Thank you, Operator. As we look back in 2020, we’re really pleased with what we were able to accomplish, both with our first approved medicine, as well as significant progress made in our pipeline. It’s an exciting time in our company and we’re committed to ensuring that patients that need our medicines have access to them. As we look to the other side of the pandemic, hopefully, we look forward to continue a dialogue with you and as we advance our long term growth strategy in 2021 and beyond. As always, we appreciate your support and interest in our company and thanks for taking the time today. Operator, you can disconnect the call at this time. Thank you.

Thank you. And thank you, ladies and gentlemen, for your participation in today’s conference. This does conclude the program. You may now disconnect. Good day.